TERT-BUTYLSULPHONAMIDE
tert-Butylsulfonamide
CAS: 34813-49-5
Molecular Formula: C4H11NO2S
TERT-BUTYLSULPHONAMIDE - Names and Identifiers
| Name | tert-Butylsulfonamide |
| Synonyms | TERT-BUTYLSULFONAMIDE tert-Butylsulfonamide TERT-BUTYLSULPHONAMIDE 2-Methylpropane-2-sulfonaMide 2-Methylpropane-2-sulfonamide 2-Propanesulfonamide, 2-methyl- 2-METHYL-PROPANE-2-SULFONIC ACID AMIDE |
| CAS | 34813-49-5 |
| InChI | InChI=1/C4H11NO2S/c1-4(2,3)8(5,6)7/h1-3H3,(H2,5,6,7) |
TERT-BUTYLSULPHONAMIDE - Physico-chemical Properties
| Molecular Formula | C4H11NO2S |
| Molar Mass | 137.2 |
| Density | 1.149±0.06 g/cm3(Predicted) |
| Melting Point | 166.0 to 170.0 °C |
| Boling Point | 223.1±23.0 °C(Predicted) |
| Flash Point | 88.7°C |
| Solubility | soluble in Methanol |
| Vapor Presure | 0.0982mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Almost white |
| pKa | 10.93±0.60(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.465 |
TERT-BUTYLSULPHONAMIDE - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
TERT-BUTYLSULPHONAMIDE - Introduction
tert-Butylsulfonamide(tert-Butylsulfonamide) is an organic compound with the chemical formula (CH3)3CSO2NH2. The following is a description of the nature, use, preparation and safety information of the tert-Butylsulfonamide:
Nature:
1. appearance: the tert-Butylsulfonamide is colorless or light yellow liquid.
2. Solubility: tert-Butylsulfonamide is soluble in most organic solvents, but hardly soluble in water.
Use:
1. as a reaction reagent: tert-Butylsulfonamide can be used in organic synthesis reactions, such as control reactions, nucleophilic substitution reactions and oxidation reactions. It can be used as an amino protecting group, participating in carboxylic acid activation reaction, etc.
2. as a catalyst: tert-Butylsulfonamide can also be used as a catalyst to participate in the oxidation reaction and the corresponding catalytic cycle.
Preparation Method:
The method of producing tert-Butylsulfonamide usually involves a four-step reaction. First, chlorosulfonyl chloride (SO2Cl2) is reacted with tert-butylamine (C4H9NH2) to form a tert-Butylsulfonamide chloride; then, the chloride is converted to tert-Butylsulfonamide by reaction with excess aqueous ammonia; next, the obtained product is distilled, reduced in pressure and crystallized to obtain a pure tert-Butylsulfonamide.
Safety Information:
1. tert-Butylsulfonamide is irritating and should avoid contact with skin, eyes and respiratory tract. Wear appropriate personal protective equipment during operation, including gloves, safety glasses and protective masks.
2. When using the tert-Butylsulfonamide, it should be carried out in a well-ventilated laboratory environment and follow the relevant safety procedures.
3. Please store the tert-Butylsulfonamide properly, away from high temperature, fire source and oxidant, to avoid leakage and fire.
4. In the event of an accident, immediately take appropriate emergency measures and seek medical advice and first aid.
Nature:
1. appearance: the tert-Butylsulfonamide is colorless or light yellow liquid.
2. Solubility: tert-Butylsulfonamide is soluble in most organic solvents, but hardly soluble in water.
Use:
1. as a reaction reagent: tert-Butylsulfonamide can be used in organic synthesis reactions, such as control reactions, nucleophilic substitution reactions and oxidation reactions. It can be used as an amino protecting group, participating in carboxylic acid activation reaction, etc.
2. as a catalyst: tert-Butylsulfonamide can also be used as a catalyst to participate in the oxidation reaction and the corresponding catalytic cycle.
Preparation Method:
The method of producing tert-Butylsulfonamide usually involves a four-step reaction. First, chlorosulfonyl chloride (SO2Cl2) is reacted with tert-butylamine (C4H9NH2) to form a tert-Butylsulfonamide chloride; then, the chloride is converted to tert-Butylsulfonamide by reaction with excess aqueous ammonia; next, the obtained product is distilled, reduced in pressure and crystallized to obtain a pure tert-Butylsulfonamide.
Safety Information:
1. tert-Butylsulfonamide is irritating and should avoid contact with skin, eyes and respiratory tract. Wear appropriate personal protective equipment during operation, including gloves, safety glasses and protective masks.
2. When using the tert-Butylsulfonamide, it should be carried out in a well-ventilated laboratory environment and follow the relevant safety procedures.
3. Please store the tert-Butylsulfonamide properly, away from high temperature, fire source and oxidant, to avoid leakage and fire.
4. In the event of an accident, immediately take appropriate emergency measures and seek medical advice and first aid.
Last Update：2024-04-10 22:29:15
