TEW-7197
EW-7197
CAS: 1352608-82-2
Molecular Formula: C22H18FN7
TEW-7197 - Names and Identifiers
TEW-7197 - Physico-chemical Properties
| Molecular Formula | C22H18FN7 |
| Molar Mass | 399.42 |
| Density | 1.40±0.1 g/cm3(Predicted) |
| Melting Point | >85oC (dec.) |
| Solubility | 10 mM in DMSO |
| Appearance | Solid |
| Color | Pale Yellow to Light Yellow |
| pKa | 8.51±0.10(Predicted) |
| Storage Condition | Refrigerator |
| In vitro study | In HaCaT (3TP-luc) and 4T1 (3TP-luc) stable cells, 12b effectively inhibited tgf-β1-induced luciferase reporter gene activity with IC50 of 16.5 and 12.1 nM, respectively. EW-7197 inhibited TGFβ-induced phosphorylation of Smad2 or Smad3 and epithelial-to-mesenchymal transformation (EMT) in TGFβ-treated breast cancer cells. In addition, EW-7197 also abrogated tgfβ1-induced tumor cell migration and invasion in mammary gland cells. |
| In vivo study | In rats, EW-7197 has an oral bioavailability of 51% with a high systemic exposure dose (AUC) of 1426 ng × h/mL and a maximum plasma concentration (Cmax). 1620 ng/mL. EW-7197 also exhibit low toxicity to the cardiovascular system, central nervous system, and respiratory system. In the mouse B16 melanoma model, EW-7197 (2.5 mg/kg daily, p.o.) enhanced cytotoxic T-lymphocyte (CTL) responses and inhibited melanoma growth. EW-7197 enhanced the activity of cytotoxic T lymphocytes in 4T1 orthotopic transplanted mice and increased the survival time of 4T1-Luc and 4T1 mammary tumor mice. |
TEW-7197 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.504 ml | 12.518 ml | 25.036 ml |
| 5 mM | 0.501 ml | 2.504 ml | 5.007 ml |
| 10 mM | 0.25 ml | 1.252 ml | 2.504 ml |
| 5 mM | 0.05 ml | 0.25 ml | 0.501 ml |
Last Update：2024-01-02 23:10:35
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Spot supply
Product Name: EW-7197 Visit Supplier Webpage Request for quotationCAS: 1352608-82-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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