TFOL-TF
2,2,2-Trifluoroethyl Trifluoromethanesulfonate
CAS: 6226-25-1
Molecular Formula: C3H2F6O3S
TFOL-TF - Names and Identifiers
| Name | 2,2,2-Trifluoroethyl Trifluoromethanesulfonate |
| Synonyms | TFOL-TF 2,2,2-TRIFLUOROETHYL TRIFLATE 2,2,2-Trifluoroethyl Trifluoromethanesulfonate 2,2,2-TRIFLUOROETHYL TRIFLUOROMETHANESULFONATE 2,2,2-TRIFLUOROETHYL TRIFLUOROMETHANESULPHONATE 2,2,2-trifluoroethyltrifluorometanesulfonicacid 2,2,2-Trifluoroethyl trifluoromethanesulphonate TRIFLUOROMETHANESULFONIC ACID 2,2,2-TRIFLUOROETHYL ESTER methanesulfonicacid,trifluoro-,2,2,2-trifluoroethylester Methanesulfonic acid, 1,1,1-trifluoro-, 2,2,2-trifluoroethyl ester |
| CAS | 6226-25-1 |
| EINECS | 458-390-7 |
| InChI | InChI=1/C3H2F6O3S/c4-2(5,6)1-12-13(10,11)3(7,8)9/h1H2 |
| InChIKey | RTMMSCJWQYWMNK-UHFFFAOYSA-N |
TFOL-TF - Physico-chemical Properties
| Molecular Formula | C3H2F6O3S |
| Molar Mass | 232.1 |
| Density | 1,61 g/cm3 |
| Boling Point | 89-91°C |
| Flash Point | >110°(230°F) |
| Water Solubility | Slightly soluble in water. |
| Solubility | Chloroform, Methanol (Slightly) |
| Vapor Presure | 38.3mmHg at 25°C |
| Appearance | Liquid |
| Color | Colorless to yellow |
| Storage Condition | 2-8°C |
| Sensitive | Moisture Sensitive |
| Refractive Index | 1.3037 |
| Use | Intermediates in organic synthesis |
TFOL-TF - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R34 - Causes burns R23/25 - Toxic by inhalation and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | 3265 |
| WGK Germany | 3 |
| RTECS | PB2775000 |
| HS Code | 29055900 |
| Hazard Note | Irritant |
| Hazard Class | TOXIC, CORROSIVE |
| Packing Group | Ⅱ |
TFOL-TF - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Application | 2,2, 2-trifluoroethyl trifluoromethanesulfonate is a colorless liquid, it can be prepared from trifluoroethanol by an acylation reaction with trifluoroacetic anhydride or trifluoromethanesulfonyl chloride. |
| preparation | in a mL reaction flask, add triethylamine (5.54mL,39.7mmol) and dichloromethane (40mL), the reaction solution was cooled to -25 °c, and then trifluoroacetic anhydride (12.5g,44.3mmol) was added dropwise. After addition, the reaction was continued at -25 °c for 2H, and then trifluoroethanol (2.71g,27.1mmol), and the reaction was stirred at room temperature overnight after the addition was completed. The reaction solution was concentrated under reduced pressure to give crude 2,2, 2-trifluoroethyl triflate as a yellow oily product (6.7g, yield 100%). |
Last Update：2024-04-09 20:52:54
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