| Molecular Formula | C14H10N4S2
|
| Molar Mass | 298.39 |
| Appearance | Powder |
| Storage Condition | -20℃ |
| Use | TP0427736 is a potent ALK5 kinase inhibitor with an IC50 of 2.72 nM and an IC50 of 836 nM for alk3. In A549 cells, it can also inhibit the phosphorylation of Smad2/3 induced by TGF-β1, and the IC50 is |
| In vitro study | TP0427736 inhibited Smad2/3 phosphorylation in a concentration-dependent manner with an IC50 of 8.68 nM. In outer root sheath cells, TP0427736 can remedy the cell proliferation inhibition caused by TGF-β1 and TGF-β2. |
| In vivo study | TP0427736 can reduce the shortening of hair follicle length during the transition period from the late growth stage to the degeneration stage. |
