TPX-0005
TPX-0005
CAS: 1802220-02-5
Molecular Formula: C18H18FN5O2
TPX-0005 - Names and Identifiers
| Name | TPX-0005 |
| Synonyms | TPX-0005 Ropotrectinib 1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)- |
| CAS | 1802220-02-5 |
TPX-0005 - Physico-chemical Properties
| Molecular Formula | C18H18FN5O2 |
| Molar Mass | 355.3662232 |
| Density | 1.46±0.1 g/cm3(Predicted) |
| Solubility | DMSO: ≥ 83.3 mg/mL |
| pKa | 10.79±0.60(Predicted) |
| Storage Condition | -20℃ |
| Physical and Chemical Properties | Bioactive Repotrectinib (TPX-0005) is a new type of ALK/ROS1/TRK inhibitor. The IC50 for WT ALK, ALK(G1202R) and ALK(L1196M) is 1.01 nM, 1.26 nM and 1.08 nM respectively. At the same time, it is also an effective SRC inhibitor, IC50 is 5.3 nM. |
TPX-0005 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.814 ml | 14.07 ml | 28.14 ml |
| 5 mM | 0.563 ml | 2.814 ml | 5.628 ml |
| 10 mM | 0.281 ml | 1.407 ml | 2.814 ml |
| 5 mM | 0.056 ml | 0.281 ml | 0.563 ml |
Last Update：2024-01-02 23:10:35
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Spot supply
Product Name: TPX-0005 Visit Supplier Webpage Request for quotationCAS: 1802220-02-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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