TRIFLUOPERAZINE
trifluoperazine
CAS: 117-89-5
Molecular Formula: C21H24F3N3S
TRIFLUOPERAZINE - Names and Identifiers
| Name | trifluoperazine |
| Synonyms | Triphthazine TRIFLUOPERAZINE trifluoperazine 10-(3-(4-methylpiperazin-1-yl)propyl)-2-trifluoromethylphenothiazine 10-(gamma-(n'-methylpiperazino)propyl)-2-trifluoromethylphenothiazine 10-(gamma-(n'-methylpiperazino)propyl)-2-trifluoromethylphenothiozine 10-(3-(4-Methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)phenothiazine 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-phenothiazin 10-[3-(4-Methylpiperazin-1-yl)propyl]-2-trifluoromethyl-10H-phenothiazine 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine dihydrochloride |
| CAS | 117-89-5 |
| EINECS | 204-219-4 |
| InChI | InChI=1/C21H24F3N3S.2ClH/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24;;/h2-3,5-8,15H,4,9-14H2,1H3;2*1H |
TRIFLUOPERAZINE - Physico-chemical Properties
| Molecular Formula | C21H24F3N3S |
| Molar Mass | 407.5 |
| Density | 1.2060 (estimate) |
| Melting Point | 232°C |
| Boling Point | bp0.6 202-210° |
| Flash Point | 259.8°C |
| Water Solubility | 12.23mg/L(24 ºC) |
| Solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| Vapor Presure | 2.32E-10mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | pKa 8.05±0.04(H2Ot = 20 0.5I not reportedbut pKawas statedto beindependentof I.) (Uncertain) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
TRIFLUOPERAZINE - Risk and Safety
| Toxicity | LD50 orally in rats, mice: 542.7, 424.0 mg/ml (Fowler) |
TRIFLUOPERAZINE - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.454 ml | 12.27 ml | 24.54 ml |
| 5 mM | 0.491 ml | 2.454 ml | 4.908 ml |
| 10 mM | 0.245 ml | 1.227 ml | 2.454 ml |
| 5 mM | 0.049 ml | 0.245 ml | 0.491 ml |
Last Update：2024-01-02 23:10:35
TRIFLUOPERAZINE - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| biological activity | Trifluoperazine (NSC-17474, RP-7623, SKF-5019) is an FDA-certified antipsychotic drug used to treat schizophrenia. It is a calmodulin (CaM) and Dopamine D2 receptor inhibitor with an IC50 value of 1.2 nM for D2 receptors. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
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