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TSC

thiosemicarbazide

CAS: 79-19-6

Molecular Formula: CH5N3S

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TSC - Names and Identifiers

Name thiosemicarbazide
Synonyms TSC
ai3-16319
Aminothiourea
aminothio-urea
N-Aminothiourea
1-Aminothiourea
n-aminothiourea
1-amino-2-thioure
thiosemicarbazide
AKOS BBS-00004328
1-Amino-2-Thiourea
3-thio-semicarbazid
2-Thiosemicarbazide
3-thiosemicarbazide
1-(aminosulfanyl)urea
LABOTEST-BB LT01593682
THIOCARBAMOYL HYDRAZIDE
HYDRAZINECARBOTHIOAMIDE
Calcineurin B homologous protein 3
CAS 79-19-6
EINECS 201-184-7
InChI InChI=1/CH5N3OS/c2-1(5)4-6-3/h3H2,(H3,2,4,5)
InChIKey BRWIZMBXBAOCCF-UHFFFAOYSA-N

TSC - Physico-chemical Properties

Molecular FormulaCH5N3S
Molar Mass91.14
Density1.221 (estimate)
Melting Point180-183°C (dec.)(lit.)
Boling Point208.6±23.0 °C(Predicted)
Water Solubilitysoluble
Solubility Soluble in water (10 mg/ml at 20 °C), ethanol, alcohols, and hot methanol.
Vapor Presure1.15Pa at 25℃
AppearanceWhite crystal
ColorWhite to light yellow
Merck14,9361
BRN506320
pKapK1:1.5(+1) (25°C,μ=0.1)
PH5-7 (50g/l, H2O, 20℃)
Storage ConditionStore at +15°C to +25°C.
StabilityStable. Incompatible with strong oxidizing agents.
SensitiveSensitive to air and light
Refractive Index1.5800 (estimate)
MDLMFCD00007620
Physical and Chemical PropertiesAppearance: white crystalline melting point: 180-182 ℃ 3-thiosemarbazide; Hydrazinecarbothioamide; TSC3-Thiosemicarbazide; Hydrazinecarbothiamide; TSC
UseThiosemicarbazide, also known as thiosemicarbazone, is an intermediate for the preparation of carbamate insecticide zosaparib and thiadiazole fungicides and rodenticides, and can also be used in the synthesis of anti-tuberculosis drugs such as amidothiuramide and sulfa drugs, rubber additives and synthetic resin additives, it can also be used as an analytical reagent for the quantification of chromium and the identification of aldehydes and ketones; Hexamethylene glycol intermediate.

TSC - Risk and Safety

Hazard SymbolsT+ - Very toxic
Very toxic
Risk CodesR28 - Very Toxic if swallowed
R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. 
R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed.
Safety DescriptionS22 - Do not breathe dust.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37 - Wear suitable protective clothing and gloves.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. 
S28A -
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
UN IDsUN 2811 6.1/PG 2
WGK Germany3
RTECSVT4200000
FLUKA BRAND F CODES8-9-23
TSCAYes
HS Code29335995
Hazard Class6.1
Packing GroupII
ToxicityLD50 orally in adult Norway rats: 13 mg/kg, Dieke, Proc. Soc. Exp. Biol. Med. 70, 688 (1949)

TSC - Nature

Open Data Verified Data

White crystalline or white crystalline powder. Melting point 180~181 °c (decomposition). Soluble in water and ethanol, needle-like crystals from water. It is easy to react with aldehydes and ketones to form specific crystal products; It is also easy to react with carboxylic acids.

Last Update：2024-01-02 23:10:35

TSC - Preparation Method

Open Data Verified Data

obtained by heating reaction of thiourea and hydrazine hydrate as raw materials. In addition, with hydrazine hydrate and ammonium thiocyanate as raw materials, using acetaldehyde as catalyst can also be prepared thiosemicarbazide.

Last Update：2022-01-01 10:38:06

TSC - Introduction

Soluble in water and ethanol, and get needle-like crystals from water. Insoluble in ether, chloroform. It is easy to react with aldehydes and ketones to form specific crystal products, and it is also easy to react with carboxylic acids.
Last Update：2022-10-16 17:28:54

TSC - Use

Open Data Verified Data

This product is an intermediate for organic synthesis, used in the synthesis of anti-tuberculosis drugs amidothiourea and sulfonamide drugs, as well as rodenticide. It can also be used as an analytical reagent for the quantification of chromium and the identification of aldehydes and ketones. In addition, this product is also used as pesticide intermediates, rubber additives and synthetic resin additives.

Last Update：2022-01-01 10:38:05

TSC - Safety

Open Data Verified Data

thiosemicarbazide is toxic, and thiosemicarbazide-containing preparations are toxic. The oral LD50 is 10-15mg/kg for mice and 19mg/kg for rats. Production equipment should be closed, the operator should wear protective equipment. This product is packed in corrugated boxes lined with polyethylene bags. lOkg per case.

storage and transportation according to toxic chemicals
Last Update：2022-01-01 10:38:06

TSC - Reference Information

LogP-1.67
NIST chemical information information provided by: webbook.nist.gov (external link)
EPA chemical substance information information provided by: ofmpeb.epa.gov (external link)
Use used in the synthesis of anti-tuberculosis drugs amidothiourea and sulfa drugs, used as pesticide intermediates, rubber additives,
thiosemicarbazide, also known as thiosemicarbazil, is an intermediate for the preparation of the carbamate insecticide oxaparb, thiadiazole bactericide and rodenticide, it can also be used for the synthesis of anti-tuberculosis drugs, such as aminothiourea and sulfanilamide, rubber additives and synthetic resin additives. It can also be used as an analytical reagent for the quantification of chromium and the identification of aldehydes and ketones.
thiosemicarbazide is an important intermediate in organic synthesis, which is commonly used in the synthesis of 2-substituted hydrazin-4-substituted thiazole antibiotics, such as Nifurthiazole. As well as an antiviral drug, e.g., phthalocyanine, etc.
used as an analytical reagent for quantitative determination of chromium and identification of aldehydes and ketones; Used as a complexing agent for copper
A complexing agent for copper. A precipitant for the determination of chromium. Reagents for the detection of certain metals and sugars, aldehydes, and ketones. Preparation of rodenticides. This product is an intermediate for organic synthesis, used in the synthesis of anti-tuberculosis drugs, ammonia thiourea and sulfa drugs, as well as rodenticides. It can also be used as an analytical reagent for the quantification of chromium and the identification of aldehydes and ketones. In addition, this product is also used as pesticide intermediates, rubber additives and synthetic resin additives.
used as analytical reagent
production method thiosemicarbazide is prepared by using hydrazine hydrate and ammonium thiocyanate as raw materials and acetaldehyde as catalyst. See the reaction equation: 2H2NNH2 · H2O + H2SO4 →(H2NNH2)2 · H2SO4 +2H2O(H2NNH2)2 · H2SO4 + 2NH4SCN → 2H2NNH2 · HSCN +(NH4)2SO4 first put a certain amount of hydrazine hydrate into three bottles, cool with water, slowly add a certain concentration of sulfuric acid under stirring, keep the temperature below 40 ℃, controlling pH = 4~5 is the end point to get hydrazine sulfate. Then add ammonium thiocyanate, stirring, at 30 ° C to add a certain amount of acetaldehyde (or acetone), and then move the reaction to the Beaker while hot, at room temperature for 4H, precipitation of crystals, after filtration, the product was washed with water and dried, and the yield was more than 80%. In addition, thiourea and hydrazine hydrate may be used as raw materials for heating reaction.
1. Thiourea and hydrazine hydrate were used as raw materials for heating reaction. 2. Hydrazine sulfate is prepared from hydrazine hydrate and sulfuric acid, which reacts with ammonium thiocyanate to produce hydrazine thiocyanate, and then reacts with acetaldehyde to obtain thiosemicarbazide by hydrolysis.
category pesticide
toxicity grade highly toxic
Acute toxicity oral-rat LD50: 9.16 mg/kg
flammability hazard characteristics toxic sulfur oxide and nitrogen oxide gases from combustion
storage and transportation characteristics The warehouse is ventilated and dried at low temperature; It is stored and transported separately from food raw materials
extinguishing agent dry powder, foam, sand
toxic substance data information provided by: pubchem.ncbi.nlm.nih.gov (external link)
Last Update：2024-04-09 20:02:46
TSC
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Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: thiosemicarbazide Request for quotation
CAS: 79-19-6
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: thiosemicarbazide Request for quotation
CAS: 79-19-6
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Guangzhou Yuanda New Material Co.,Ltd
Product Name: thiosemicarbazide Request for quotation
CAS: 79-19-6
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589 Click to send a QQ message
Wechat: +86 19849939632
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: thiosemicarbazide Request for quotation
CAS: 79-19-6
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: TSC Visit Supplier Webpage Request for quotation
CAS: 79-19-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Shanghai Worldyang Chemical Co.,Ltd.
Product Name: N-Aminothiourea Request for quotation
CAS: 79-19-6
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228 Click to send a QQ message
Wechat: 13651600618
WhatsApp: +8613651600618
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