TUBERCIDINE
tubercidin from streptomyces tubercidicus
CAS: 69-33-0
Molecular Formula: C11H14N4O4
TUBERCIDINE - Names and Identifiers
| Name | tubercidin from streptomyces tubercidicus |
| Synonyms | TUBERCIDIN Tubercidin TUBERCIDINE 7-deaza-adenosin tubercidin from streptomyces tubercidicus 3-d)pyrimidin-4-amine,7-beta-d-ribofuranosyl-7h-pyrrolo( 4-amino-7-(beta-d-ribofuranosyl)-pyrrolo(2,3-d)pyrimidine 3-d)pyrimidine,4-amino-7-beta-d-ribofuranosyl-7h-pyrrolo( 7-beta-d-ribofuranosyl-7h-pyrrolo(2,3-d)pyrimidine-4-amine 4-amino-7-beta-d-ribofuranosyl-7h-pyrrolo(2,3-d)pyrimidine |
| CAS | 69-33-0 |
| EINECS | 200-703-4 |
| InChI | InChI=1/C11H14N4O4/c12-9-5-1-2-15(10(5)14-4-13-9)11-8(18)7(17)6(3-16)19-11/h1-2,4,6-8,11,16-18H,3H2,(H2,12,13,14)/t6-,7-,8-,11-/m1/s1 |
| InChIKey | HDZZVAMISRMYHH-UIRWVKCDSA-N |
TUBERCIDINE - Physico-chemical Properties
| Molecular Formula | C11H14N4O4 |
| Molar Mass | 266.25 |
| Density | 1.2896 (rough estimate) |
| Melting Point | 247-248 °C (decomp)(Solv: water (7732-18-5)) |
| Boling Point | 409.46°C (rough estimate) |
| Specific Rotation(α) | D17 -67° (50% acetic acid) |
| Flash Point | 346.2°C |
| Vapor Presure | 1.02E-17mmHg at 25°C |
| Appearance | powder |
| Color | off-white |
| Merck | 13,9875 |
| BRN | 38498 |
| pKa | 12.44±0.70(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 1.8340 (estimate) |
| In vitro study | Fourteen consecutive days of tubercidin treatment had a highly toxic effect on both CFU-GM and BFU-E. The IC50 of tubercidin was 3.4±1.7 and 3.7±0.2 nM in CFU-GM and BFU-E, respectively. In vitro experiments, Tubercidin has a concentration-dependent inhibitory effect on myeloid and erythroid human bone marrow cells. |
| In vivo study | Daily injections of 5 mg/kg of tubercidin to mice for 4 consecutive days will kill the mice. Some studies have suggested that deaths caused by tubercidin may be due to damage to the liver and kidneys, or, very slightly, to the pancreas. Co-injection of tubercidin and NBMPR-P protected the mice from death. |
TUBERCIDINE - Risk and Safety
| Hazard Symbols | T+ - Very toxic |
| Risk Codes | 28 - Very Toxic if swallowed |
| Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3462 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | UY8870000 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 29419090 |
| Hazard Class | 6.1(a) |
| Packing Group | II |
| Toxicity | LD50 i.v. in mice: 45 mg/kg (Anzai) |
TUBERCIDINE - Nature
Open Data Verified Data
unpurified tuberculin is a brown clear liquid; Purified tuberculin is a colorless or yellowish brown clear liquid; Freeze-dried purified tuberculin is a milky white or yellowish brown loose mass, the diluted solution was added and dissolved rapidly.
Last Update：2024-01-02 23:10:35
TUBERCIDINE - Preparation Method
Open Data Verified Data
- this strain is inoculated with 1-2 strains of bovine or avian Mycobacterium tuberculosis in appropriate culture medium, and the culture is harvested, inactivated, filtered and sterilized, and concentrated to make a preliminary product, the purified product is obtained by purification, and then freeze-dried by vacuum drying to obtain a freeze-dried purified product.
- preparation of liquid purified tuberculin diluent: sodium chloride 5.0G, phenol 3.5G, glycerol lOOmL, anhydrous disodium hydrogen phosphate 3. 45g, potassium dihydrogen phosphate 1.22g, add normal saline to looml, adjust to pH 7.2, filter through sterilized Seawell filter, standby.
Last Update：2022-01-01 11:19:15
TUBERCIDINE - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.63 ml | 13.148 ml | 26.296 ml |
| 5 mM | 0.526 ml | 2.63 ml | 5.259 ml |
| 10 mM | 0.263 ml | 1.315 ml | 2.63 ml |
| 5 mM | 0.053 ml | 0.263 ml | 0.526 ml |
Last Update：2024-01-02 23:10:35
TUBERCIDINE - Use
Open Data Verified Data
- for intradermal allergy diagnosis of animal tuberculosis. Diagnosis of bovine tuberculosis, bovine tuberculin; Diagnosis of chicken tuberculosis, avian tuberculin. Diagnosis of horses, sheep, goats, swine tuberculosis, with cattle, two kinds of avian tuberculin.
- formulation and specification formulation or lyophilized formulation. Bovine tuberculin: 2.0 mL/bottle, 5.0 mL/bottle, 10.0 ml/bottle; Avian tuberculin: 1.0 mL/bottle, 2.0 mL/bottle, 5.0 mL/bottle.
Last Update：2022-01-01 11:19:15
TUBERCIDINE - Safety
Open Data Verified Data
when stored at 2~8 ℃, the period of validity of purified tuberculin was 120 months, that of liquid purified tuberculin was 24 months, and that of unpurified tuberculin was 60 months.
Last Update：2022-01-01 11:19:16
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CAS: 69-33-0
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Product Name: Tubercidin Trifluoroacetate Visit Supplier Webpage Request for quotation
CAS: 69-33-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 69-33-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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