Name | TYR-D-ALA-GLY-PHE-LEU |
Synonyms | TYR-D-ALA-GLY-PHE-LEU D-ALA2-LEU5-ENKEPHALIN (D-ALA2)-LEU-ENKEPHALIN H-TYR-D-ALA-GLY-PHE-LEU-OH [D-ALA2]-LEUCINE ENKEPHALIN (D-alanine2)leucine enkephalin L-Tyr-D-Ala-Gly-L-Phe-L-Leu-OH N-[N-[N-(N-L-tyrosyl-D-alanyl)glycyl]-L-phenylalanyl]-L-leucine |
CAS | 64963-01-5 |
EINECS | 265-291-0 |
InChIKey | ZHUJMSMQIPIPTF-JMBSJVKXSA-N |
Molecular Formula | C29H39N5O7 |
Molar Mass | 569.65 |
Density | 1.257±0.06 g/cm3(Predicted) |
Melting Point | 160-163.5 °C |
Boling Point | 991.9±65.0 °C(Predicted) |
Solubility | DMF (Slightly), DMSO (Slightly) |
Appearance | Solid |
Color | White to Off-White |
pKa | 3.40±0.10(Predicted) |
Storage Condition | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
WGK Germany | 3 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.755 ml | 8.777 ml | 17.555 ml |
5 mM | 0.351 ml | 1.755 ml | 3.511 ml |
10 mM | 0.176 ml | 0.878 ml | 1.755 ml |
5 mM | 0.035 ml | 0.176 ml | 0.351 ml |
overview | (D-ALA2)-leucine enkephalin is widely distributed in human body and has extremely important physiological functions. Not only has a unique effect on brain cells, it can activate brain cells in a sleeping state, and has a good recovery effect on sequelae caused by brain injury; it plays an important role in immune function, including increasing the immune system and T The activity of lymphocytes, NK cells, macrophages, etc., anti-virus, increase the release of gamma-interferon, etc.; the activated immune cells promote the secretion of endocrine cells to participate in immune regulation, then it has an impact on the gene regulation and expression function of DNA. |
application | (D-ALA2)-leucine enkephalin is an organic synthesis intermediate and a pharmaceutical intermediate, which can be used in the process of laboratory organic research and development and chemical medicine research and development, especially in the process of biochemical research and development. |
biological activity | [D-Ala2]leucine-enkephalin is a delta opioid agonist and a leucine brain non-peptide that can resist degradation for a long time. |