Taladegib
LY2940680
CAS: 1258861-20-9
Molecular Formula: C26H24F4N6O
Taladegib - Names and Identifiers
Taladegib - Physico-chemical Properties
| Molecular Formula | C26H24F4N6O |
| Molar Mass | 512.5 |
| Density | 1.39 |
| Boling Point | 703.5±60.0 °C(Predicted) |
| Solubility | DMSO 0.66 mg/mL (1.28 mM); Water <1 mg/mL (<1 mM); Ethanol 2 mg/mL (3.9 mM) |
| pKa | 7.94±0.30(Predicted) |
| Storage Condition | -20℃ |
| MDL | MFCD21609264 |
| In vitro study | LY2940680 inhibits cancer growth in cell lines containing a mutation in the gene encoding Smoothened that researchers had previously observed in patient with cancer who developed resistance to vismodegib. |
| In vivo study | LY2940680 has excellent pharmacokinetic properties in rodent and non-rodent species. LY2940680 administrated orally treats Ptch+/- p53-/- transgenic mice which spontaneously develop medulloblastoma, produces remarkable efficacy and significantly improves their survival. LY2940680 reveals rapid kinetics of anti-tumor activity through magnetic resonance imaging of these mice, and LY2940680 induces Caspase-3 activity and reduces proliferation by immunohistochemistry analysis of medulloblastoma tumors. LY2940680 inhibits Hh regulated gene expression in the subcutaneous xenograft tumor stroma and produces significant anti-tumor activity. |
Taladegib - Introduction
LY2940680 binds to Smoothened(Smo) receptor and effectively inhibits Hedgehog(Hh) signaling pathway. Phase 1/2.
Last Update：2022-10-16 17:41:23
Taladegib - Reference Information
| biological activity | Taladegib (LY2940680) binds to Smoothened(Smo) receptor to effectively inhibit Hedgehog(Hh) signaling pathway. Phase 1/2. Taladegib (LY2940680) binds to Smoothened(Smo) receptor to effectively inhibit Hedgehog(Hh) signaling pathway. Phase 1/2. |
| in vitro study | LY2940680 inhibits cancer growth in cell lines containing a mutation in the gene encoding Smoothened that researchers had previously observed in patient with cancer who developed resistance to vismodegib. |
| in vivo study | LY2940680 has excellent pharmacokinetic properties in rodent and non-rodent species. LY2940680 administrated orally treat Ptch /- p53-/- transgenic mice which spontaneously develop medulloblastoma, produces remarkable efficacy and significantly improves their survival. LY2940680 reveals rapid kinetics of anti-tumor activity through magnetic resonance imaging of these mice, and LY2940680 induces Caspase-3 activity and reduces proliferation by immunohistochemistry analysis of medulloblastoma tumors. LY2940680 inhibits Hh regulated gene expression in the subcutaneous xenograft tumor stroma and produces significant anti-tumor activity. |
| target | TargetValue Smoothened |
| Target | Value |
Last Update：2024-04-09 19:05:03
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CAS: 1258861-20-9
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CAS: 1258861-20-9
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Product Name: LY2940680 Visit Supplier Webpage Request for quotation
CAS: 1258861-20-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1258861-20-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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