Temozolomide
Temozolomide
CAS: 85622-93-1
Molecular Formula: C6H6N6O2
Temozolomide - Names and Identifiers
| Name | Temozolomide |
| Synonyms | 85622-93-1 Temozolomide 4-Methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide |
| CAS | 85622-93-1 |
| InChI | InChI=1/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13) |
Temozolomide - Physico-chemical Properties
| Molecular Formula | C6H6N6O2 |
| Density | 1.97±0.1 g/cm3(Predicted) |
| Melting Point | 212 °C (decomp) |
| Boling Point | 526.6±42.0 °C(Predicted) |
| Solubility | DMSO |
| Appearance | White to light brown powder |
| pKa | 14.77±0.20(Predicted) |
| Storage Condition | 2-8℃ |
| Sensitive | Sensitive to heat |
| MDL | MFCD00866492 |
| Physical and Chemical Properties | Light brown solid. |
| Use | Used as an antineoplastic agent |
Temozolomide - Reference
| Reference Show more | 1. Yingjun Zhu, Peiyuan Zhao, Peng-Yun Qi, Xihong Liu, Hui Zhao, Wei Gao, Yongping fan, Li Zhou, Lei Wang. Effect of Fuzheng Yiliu decoction combined with temozolomide on inhibiting the growth of rat brain glioma and regulating blood tumor barrier related proteins [J]. Global Journal of Traditional Chinese Medicine, 2018,11(01):34-39. 2. [IF = 2.4] Shan Zhang et al."A sterotal saponin form Paris Vietnam (Takht.) reverses temozolide resistance in gliobastoma cells via induction through ROS/PI3K/Akt pathway." Biosci Trends. 2020 Apr;14(2):123-133 3. [IF = 3.642] Yu-Ye Xue et al."CN-3 increases TMZ sensitivity and induces ROS-dependent apotosis and autophagy in TMZ-resistance gliobastoma." Journal Of Biomedical And Molecular biology. 2021 Dec 29 |
Temozolomide - Nature
Open Data Verified Data
white or light pink crystalline powder, slightly soluble in water, soluble in hot water. Crystallization from dichloromethane, melting point 212 °c (decomposition). UV absorption maximum (95% ethanol):327nm.
Last Update：2024-01-02 23:10:35
Temozolomide - Preparation Method
Open Data Verified Data
5-amino -4-formylaminoimidazole was diazotized with nitrous acid, and then reacted with methyl isocyanate in dichloromethane to obtain temozolomide.
Last Update：2022-01-01 09:09:09
Temozolomide - Use
Open Data Verified Data
The United States Schering-Plough development, 1999 marketing. Temozolomide is a new anti-tumor drug. In vivo, MTIC can be spontaneously and rapidly degraded to produce the active metabolite, MTIC., which has an anti-tumor effect. It is used as a therapeutic drug for malignant gliomas and malignant melanomas in adults.
Last Update：2022-01-01 09:09:09
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