Name | Tetrahydrozoline |
Synonyms | Tyzanol Tetryzolin TETRYZOLNE Tetryzoline TETRYZOLINE Tetrahydrozoline 2-(1,2,3,4-Tetrahydro-1-napthyl)-2-imidazoline 2-(1,2,3,4-Tetrahydro-1-naphthyl)-2-imidazoline 2-Imidazoline, 2-(1,2,3,4-tetrahydro-1-naphthyl)- 2-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole 2-(1,2,3,4-Tetrahydro-1-naphthalenyl)-4,5-dihydro-1H-imidazole 1H-Imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)- |
CAS | 84-22-0 |
EINECS | 201-522-3 |
InChI | InChI=1/C13H16N2/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13/h1-2,4,6,12H,3,5,7-9H2,(H,14,15) |
Molecular Formula | C13H16N2 |
Molar Mass | 200.28 |
Density | 1.20±0.1 g/cm3(Predicted) |
Melting Point | 117-119 °C(Solv: heptane (142-82-5); ethanol (64-17-5)) |
Boling Point | 393.5±21.0 °C(Predicted) |
Flash Point | 191.8°C |
Vapor Presure | 4.8E-06mmHg at 25°C |
pKa | pKa 10.51 (Uncertain) |
Storage Condition | 2-8℃ |
Refractive Index | 1.656 |
In vitro study | Tetrahydrozoline (0.05% HCl-tetrahydrozoline diluted with DMEM to 1:20 concentration; 24 hours) induces the synthesis of collagen types I and III in primary human gingival fibroblasts. |
NIST chemical information | information provided by: webbook.nist.gov (external link) |
Overview | the effect of tetrahydro-oxazoline is similar to that of naphthoazoline. Clinical use of its 0.1% solution nasal drops, symptomatic treatment of rhinitis, sinusitis; Can also be its 0.05% solution eye drops, treatment of conjunctival congestion. It can be absorbed from the site of administration, but also from the gastrointestinal tract. Matters needing attention are the same as those of naphthazoline. |
Use | tetrahydroazoline is a chemical that has a flash point of 191.8°C and is a white crystalline powder compound. Clinically, this product belongs to the sympathetic nerve medicine, as a vasoconstrictor, can quickly eliminate nasal mucosa and conjunctival congestion. |
biological activity | Tetrahydrozoline (Tetryzoline) is a derivative of imidazoline, which is a kind of α-Adrenergic agonists that can cause vasoconstriction. Tetrahydrozoline is widely used in the study of nasal congestion, Conjunctival Congestion. |
toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |