Tetraisopropylazodicarboxamide
Tetraisopropylazodicarboxamide
CAS: 155877-06-8
Molecular Formula: C14H28N4O2
Tetraisopropylazodicarboxamide - Names and Identifiers
Tetraisopropylazodicarboxamide - Physico-chemical Properties
| Molecular Formula | C14H28N4O2 |
| Molar Mass | 284.4 |
| Density | 1.02±0.1 g/cm3(Predicted) |
| Boling Point | 341.2±25.0 °C(Predicted) |
| pKa | -0.76±0.70(Predicted) |
Tetraisopropylazodicarboxamide - Introduction
Tetraisopropylazodicarboxamide(Tetraisopropylazodicarboxamide) is an organic compound. Its molecular formula is C10H18N4O2 and its structural formula is [(CH3)2CH]2N-N = C(= O)N-C(= O)N[(CH3)2CH]2. The following is a description of the properties, use, preparation and safety information of this compound:
Nature:
1. Appearance and physical state: Tetraisopropylazodicarboxamide is a colorless to light yellow liquid;
2. Solubility: It has good solubility in organic solvents, but low solubility in water;
3. Melting point and boiling point: The melting point of the compound is -65 to -63°C, and the boiling point is 185 to 188°C.
Use:
1. Tetraisopropylazodicarboxamide is often used as oxidant and nitrogen source in organic synthesis;
2. It can be used to synthesize organic heterocyclic compounds, such as piperazine and indole derivatives;
3. It can also be used as a catalyst and reaction intermediate.
Preparation Method:
The preparation method of the Tetraisopropylazodicarboxamide is as follows:
1. First, an ethyl ester solution of 2,2, 2-tricyanoacetic acid is reacted with isopropylamine to obtain isopropyl 2,2, 2-tricyanoacetate hydrochloride.
2. Then, isopropyl 2,2, 2-tricyanoacetate hydrochloride was reacted with sodium azide to generate Tetraisopropylazodicarboxamide.
Safety Information:
1. Tetraisopropylazodicarboxamide is an organic compound with certain toxicity. Care should be taken to avoid contact with skin and inhalation;
2. during use or storage, attention should be paid to prevent contact with strong oxidants and acidic substances to avoid dangerous reactions;
3. Wear appropriate protective equipment, such as gloves, goggles and protective clothing, to ensure that the operating environment is well ventilated.
Nature:
1. Appearance and physical state: Tetraisopropylazodicarboxamide is a colorless to light yellow liquid;
2. Solubility: It has good solubility in organic solvents, but low solubility in water;
3. Melting point and boiling point: The melting point of the compound is -65 to -63°C, and the boiling point is 185 to 188°C.
Use:
1. Tetraisopropylazodicarboxamide is often used as oxidant and nitrogen source in organic synthesis;
2. It can be used to synthesize organic heterocyclic compounds, such as piperazine and indole derivatives;
3. It can also be used as a catalyst and reaction intermediate.
Preparation Method:
The preparation method of the Tetraisopropylazodicarboxamide is as follows:
1. First, an ethyl ester solution of 2,2, 2-tricyanoacetic acid is reacted with isopropylamine to obtain isopropyl 2,2, 2-tricyanoacetate hydrochloride.
2. Then, isopropyl 2,2, 2-tricyanoacetate hydrochloride was reacted with sodium azide to generate Tetraisopropylazodicarboxamide.
Safety Information:
1. Tetraisopropylazodicarboxamide is an organic compound with certain toxicity. Care should be taken to avoid contact with skin and inhalation;
2. during use or storage, attention should be paid to prevent contact with strong oxidants and acidic substances to avoid dangerous reactions;
3. Wear appropriate protective equipment, such as gloves, goggles and protective clothing, to ensure that the operating environment is well ventilated.
Last Update：2024-04-10 22:29:15
