TfR-T12
L-Proline, L-threonyl-L-histidyl-L-arginyl-L-prolyl-L-prolyl-L-methionyl-L-tryptophyl-L-seryl-L-prolyl-L-valyl-L-tryptophyl-
CAS: 344618-30-0
Molecular Formula: C71H99N19O15S
TfR-T12 - Names and Identifiers
TfR-T12 - Physico-chemical Properties
| Molecular Formula | C71H99N19O15S |
| Molar Mass | 1490.73 |
| Density | 1.53±0.1 g/cm3(Predicted) |
| pKa | 3.42±0.20(Predicted) |
| In vitro study | TfR-T12 binds to the TfR and is subsequently internalized into TfR-expressing cells. TfR-T12 is a synthetic peptide obtained by phage display, and is able to bind a different site on TfRs compared with transferrin. TfR-T12 can be chemically conjugated with a pegylated lipid derivative, 3-(N-succinimidyloxyglutaryl)aminopropyl- polyethyleneglycol(2000)- carbamyl distearoyl phosphatidylethanolamine (NHS-PEG2000-DSPE), and used as a functional material to construct the multifunctional lipid vesicles. |
TfR-T12 - Reference Information
| Biological activity | TfR-T12 is a binding peptide of transferrin receptor (TfR) that can penetrate the blood-brain barrier, showing binding activity at nM level. |
| in vitro study | TfR-T12 binds to the TfR and is subsequently internalized into TfR-expressing cells. TfR-T12 is a synthetic peptide obtained by phage display, and is able to bind a different site on TfRs compared with transferrin. TfR-T12 can be chemically conjugated with a pegylated lipid derivative, 3-(N-succinimidyloxyglutaryl)aminopropyl- polyethyleneglycol(2000)- carbamyl distearoyl phosphatidylethanolamine (NHS-PEG2000-DSPE), and used as a functional material to construct the multifunctional lipid vesicles. |
Last Update：2024-04-10 22:43:14
