Thevetiaflavone
Thevetiaflavone
CAS: 29376-68-9
Molecular Formula: C16H12O5
Thevetiaflavone - Names and Identifiers
| Name | Thevetiaflavone |
| Synonyms | Thevetiaflavone 5-O-METHYLAPIGENIN Apigenin 5-methylether Apigenin 5-O-monomethyl ether 4',7-Dihydroxy-5-methoxyflavone Flavone,4',7-dihydroxy-5-methoxy- (8CI) Apigenin-5-methyl ether,5-0-Methylapigenin 7-Hydroxy-2-(4-hydroxyphenyl)-5-methoxy-4H-chromen-4-one 4H-1-Benzopyran-4-one,7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy- |
| CAS | 29376-68-9 |
Thevetiaflavone - Physico-chemical Properties
| Molecular Formula | C16H12O5 |
| Molar Mass | 284.26 |
| Density | 1.420 |
| Melting Point | 263℃ |
| Boling Point | 567.9±50.0 °C(Predicted) |
| Appearance | Yellow powder |
| pKa | 6.67±0.40(Predicted) |
| Storage Condition | 2-8℃ |
| In vitro study | Thevetiaflavone, a natural flavonoid obtained from Wikstroemia indica, could improve cell viability and suppresses the leakage of lactate dehydrogenase from the cytoplasm. Further investigation of the mechanisms demonstrated that Thevetiaflavone decreases overproduction of ROS and ameliorates ROS‑mediated mitochondrial dysfunction, including collapse of mitochondrial membrane potential and mitochondrial permeability transition pore opening. Thevetiaflavone reduces the intracellular Ca 2+ level, which is closely associated with mitochondrial function and interplays with ROS. Furthermore, Thevetiaflavone inhibits apoptosis in PC12 cells through upregulating the expression of Bcl‑2 and downregulating that of Bax and caspase‑3 in addition to increasing the activity of caspase‑3. These results further indicate the protective effects of thevetiaflavone in vivo and its application in the clinic. |
Thevetiaflavone - Introduction
Thevetiaflavone is a natural phytochemical found mainly in the Oleander plant. It has some important properties and uses.
Nature:
Thevetiaflavone is a polyphenol compound with the appearance of yellow crystalline powder. It is a natural antioxidant with good free radical scavenging ability. In addition, it also has anti-inflammatory, antibacterial, analgesic, anti-tumor and other biological activities.
Use:
Thevetiaflavone has a wide range of applications. In the food industry, it can be used as an antioxidant and food preservative to increase the stability and shelf life of food. In the pharmaceutical field, it can be used in the manufacture of anti-inflammatory drugs and anti-tumor drugs. In addition, it can also be used in cosmetics, health products and dyes.
Preparation Method:
Thevetiaflavone extraction methods usually include extraction, solvent extraction and purification steps. First, the flowers of the yellow flower oleander plant or other parts containing flavonoids are crushed and soaked, and then extracted with an appropriate solvent to remove impurities and solvents, and finally the extract is purified by crystallization, distillation or column chromatography and other methods to obtain Thevetiaflavone.
Safety Information:
Although Thevetiaflavone has many medicinal and biological activities, it is still necessary to pay attention to safety issues during use. It may cause allergic reactions in some people, so skin sensitivity testing should be done before use. In addition, excessive intake should be avoided to avoid adverse reactions. If symptoms of discomfort occur, discontinue use and consult a doctor's advice. In addition, the toxicology of Thevetiaflavone and the safety of long-term use need further research and evaluation.
Nature:
Thevetiaflavone is a polyphenol compound with the appearance of yellow crystalline powder. It is a natural antioxidant with good free radical scavenging ability. In addition, it also has anti-inflammatory, antibacterial, analgesic, anti-tumor and other biological activities.
Use:
Thevetiaflavone has a wide range of applications. In the food industry, it can be used as an antioxidant and food preservative to increase the stability and shelf life of food. In the pharmaceutical field, it can be used in the manufacture of anti-inflammatory drugs and anti-tumor drugs. In addition, it can also be used in cosmetics, health products and dyes.
Preparation Method:
Thevetiaflavone extraction methods usually include extraction, solvent extraction and purification steps. First, the flowers of the yellow flower oleander plant or other parts containing flavonoids are crushed and soaked, and then extracted with an appropriate solvent to remove impurities and solvents, and finally the extract is purified by crystallization, distillation or column chromatography and other methods to obtain Thevetiaflavone.
Safety Information:
Although Thevetiaflavone has many medicinal and biological activities, it is still necessary to pay attention to safety issues during use. It may cause allergic reactions in some people, so skin sensitivity testing should be done before use. In addition, excessive intake should be avoided to avoid adverse reactions. If symptoms of discomfort occur, discontinue use and consult a doctor's advice. In addition, the toxicology of Thevetiaflavone and the safety of long-term use need further research and evaluation.
Last Update：2024-04-09 21:01:54
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Product Name: Thevetiaflavone Visit Supplier Webpage Request for quotation
CAS: 29376-68-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 29376-68-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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