Thymidine,3'-azido-3'-deoxy-5'-O-(triphenylmethyl)

Thymidine,3'-azido-3'-deoxy-5'-O-(triphenylmethyl) - Names and Identifiers

Name	Thymidine,3'-azido-3'-deoxy-5'-O-(triphenylmethyl)
Synonyms	Zidovudine impurity Q Trityl Azido Thymidine 3''-AZIDO-3''-DEOXY-5''-O-TRITYLTHYMIDINE 3-Azido-3-deoxy-5-O-triphenylmethylthymidine 3'-Azido-5'-O-trityl-2',3'-dideoxy-5-methyluridine Thymidine,3'-azido-3'-deoxy-5'-O-(triphenylmethyl) 1-(4-azido-5-trityloxymethyl-tetrahdyro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione 1-(4-azido-5-((trityloxy)methyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 1-((2R,4S,5S)-4-azido-5-((trityloxy)Methyl)tetrahydrofuran-2-yl)-5-MethylpyriMidine-2,4(1H,3H)-dione
CAS	29706-84-1

Thymidine,3'-azido-3'-deoxy-5'-O-(triphenylmethyl) - Physico-chemical Properties

Molecular Formula	C29H27N5O4
Molar Mass	509.563
Melting Point	103-104 °C(Solv: toluene (108-88-3))
Storage Condition	2-8℃

Thymidine,3'-azido-3'-deoxy-5'-O-(triphenylmethyl) - Introduction

Thymidine,3 '-azido-3'-deoxy-5 '-O-(triphenylmethyl) is a chemical compound containing a zido (azido) group and a trityl (triphenylmethyl) group in its chemical structure. It is a modified deoxyguanosine (thymidine) with some special properties and uses.

Nature:
- Thymidine,3 '-azido-3'-deoxy-5 '-O-(triphenylmethyl) is a white solid with high thermal stability.
-It has good solubility in solvents and can be dissolved in some common organic solvents, such as dimethyl sulfoxide (DMSO) and methanol.
-Relatively stable under conventional experimental conditions, but sensitive to strong alkali and acidic conditions.

Use:
- Thymidine,3 '-azido-3'-deoxy-5 '-O-(triphenylmethyl) is mainly used in the field of biochemical research, especially in the search for new antiviral and anti-cancer compounds.
-Due to the presence of the zidovudine group, the compound can be used to synthesize DNA chain markers and primers for nucleic acid sequencing, primer amplification and genetic engineering.
-It can also be used to study DNA repair and replacement mechanisms and the interaction between DNA and proteins.

Preparation Method: The preparation of
- Thymidine,3 '-azido-3'-deoxy-5 '-O-(triphenylmethyl) is generally carried out by organic synthesis methods, including a multi-step reaction sequence.
-A commonly used preparation method is to prepare the compound by introducing a zidovudine group into the deoxyguanosine molecule, and then adding a trityl protecting group.

Safety Information:
- Thymidine,3 '-azido-3'-deoxy-5 '-O-(triphenylmethyl) The potential risks to human health and the environment have not been fully assessed.
-During handling and use, follow appropriate laboratory practices, including wearing appropriate protective equipment and use of ventilation systems to prevent skin contact and inhalation.
-The compound should be stored in a dry, cool, dark place, away from flammable substances and oxidizing agents.
-When handling this compound, you should follow local safety regulations and avoid unnecessary exposure.

Last Update：2024-04-09 21:04:16