Thyminose
2-Deoxy-D-ribose
CAS: 533-67-5
Molecular Formula: C5H10O4
Thyminose - Names and Identifiers
| Name | 2-Deoxy-D-ribose |
| Synonyms | Thyminose Deoxyribose deoxyribose 2-Deoxypentose D-2-DEOXYRIBOSE 2-Deoxy-D-ribose 2-Desoxy ribosoe D-Ribose, 2-deoxy- D-(-)-2-DEOXYRIBOSE D-.alpha.-Ribodesose 2-deoxy-D-threo-pentose 2-deoxy-L-threo-pentose 2-deoxy-D-erythropentose 2-deoxy-d-erythro-pentos 2-Deoxy-beta-D-erythro-pentose 2-deoxy-D-erythro-pentofuranose 2-deoxy-D-erythro-pentopyranose 2-deoxy-alpha-D-erythro-pentofuranose 2-deoxy-alpha-D-erythro-pentopyranose |
| CAS | 533-67-5 |
| EINECS | 208-573-0 |
| InChI | InChI=1/C5H10O4/c6-2-4-3(7)1-5(8)9-4/h3-8H,1-2H2/t3-,4+,5-/m0/s1 |
| InChIKey | ASJSAQIRZKANQN-CRCLSJGQSA-N |
Thyminose - Physico-chemical Properties
| Molecular Formula | C5H10O4 |
| Molar Mass | 134.13 |
| Density | 1.0590 (rough estimate) |
| Melting Point | 89-90°C(lit.) |
| Boling Point | 167.23°C (rough estimate) |
| Specific Rotation(α) | -57 º (c=1, H2O, 24hr) |
| Flash Point | 173.344°C |
| Water Solubility | soluble |
| Solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated) |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White powder |
| Color | White to slightly yellow |
| Merck | 14,2908 |
| BRN | 1721978 |
| pKa | 12.61(at 25℃) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Stability | Hygroscopic |
| Sensitive | Hygroscopic |
| Refractive Index | -56 ° (C=1, H2O) |
| MDL | MFCD00135904 |
| Physical and Chemical Properties | Melting point 89-90°C(lit.) specific optical rotation -57 ° (c = 1, H2O, 24hr) refractive index -56 ° (C = 1, H2O) Storage Conditions 2-8°C water-soluble solution Merck 14,2908 BRN 1721978 |
Thyminose - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S37/39 - Wear suitable gloves and eye/face protection S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | SB7230000 |
| FLUKA BRAND F CODES | 3-10 |
| TSCA | Yes |
| HS Code | 29400000 |
Thyminose - Reference
| Reference Show more | 1. Zhang Huan, Zhang Liwei. Antioxidant activity of safflower yellow pigment [J]. Chemical Research and Application, 2012,24(05):715-721. 2. Feng Junye, Li Jiaqi, Wang Ping. Quality changes and volatile compounds analysis of wild Lonicera edulis during fermentation [J]. Modern food science and technology, 2018, 34(11):117-124. 3. Academic Edition) 2018 036(005):82-91 105. 4. Sui Shuang, Zhou Sainan, Wang Ping. Preliminary identification and application of main microorganisms in constant temperature natural fermentation of Vaccinium uliginosum [J]. Modern food science and technology,, 034(009):102-110,149. 5. Ting Hu, Chen Bo Jiang, Qilin Huang, Feng Yuan Sun, A comb-like branched β-d-glucan produced by a Cordyceps sinensis fungus and its protective effect against cyclophosphamide-induced immunosuppression in mice, Carbohydrate Polymers, Volume 142, 2016, Pages 2 |
Thyminose - Introduction
Soluble in water, pyridine, slightly soluble in alcohol.
Last Update：2022-10-16 17:25:59
Thyminose - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| introduction | 2-deoxy-D-ribose is the basic raw material and key intermediate of nucleoside drugs. it is mainly used to manufacture antiviral drugs and anti-tumor drugs, such as zidovudine, lamivudine and stavudine. it is mostly used to treat AIDS, hepatitis B and tumor, and has important development value and market prospect. |
| Use | 2-deoxyd-ribose induces apoptosis by inhibiting the synthesis of glutathione and increasing its efflux. 2-deoxy-D-ribose is the basic raw material and key intermediate of nucleoside drugs. At present, it is mainly used to manufacture antiviral drugs and anti-tumor drugs, such as zidovudine, lamivudine and stafudine. It is mostly used to treat AIDS, hepatitis B and tumor, and has important development value and market prospect. 2-Deoxy-D-ribose is mainly used in the synthesis of important intermediates for the production of nucleoside products, biochemistry and other scientific research. |
| application | 2-deoxyribose can carry out a variety of special color reactions and can be quantitatively determined. |
| production process | 2-deoxyd ribose is a very widely used monosaccharide. it is the main raw material in the pharmaceutical field, especially in the synthesis of antiviral drugs. it has important value and the demand is increasing day by day. there are two routes reported in the literature: one is Tetrahedron Letters40 ,3983(1967) ;Mikio shibuya etc, prepared from propionaldehyde; The other route is J.Am.Chem.Soc. 76 ,3541(1954) ;J.C.Sowden, prepared from glucose. the first route, the price of raw materials is relatively expensive, there are many reaction steps, the process is more complicated, and the overall cost is high. In the second route, the raw materials are simple and easy to obtain, but the amount is large and the relative yield is low. |
| Biological activity | 2-Deoxy-D-ribose (Thyminose, Deoxyribose) is an endogenous metabolite. |
Last Update：2024-04-09 21:04:16
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