Tiocarone

Name	Thioacetazone
Synonyms	Tubin Tibon Antib Ilbion 4207rp Diasan A 4081 Thizone Tibizan Neustab Tebezon Mivizon Seroden Thibone Panrone Novakol Aktivan Tebemar Tibicur 4207 RP Tebalon Tubigal Domakol Conteben Myvizone Tebecure Berkazon Parazone Neotibil Livazone Tiobicina Tebethion Thiomicid Amitiozon Tiocarone Thionicid Tiosecolo Tubercazon Thiacetone Tiacetazon Ambathizon Amithiozone Tioacetazon Benthiozone Thiotebesin Thiotebezin Thiacetozone Tioatsetazon Thiotebicina Thiocarbazil Benzothiozon Siocarbazone Thiacetazone Benzothiozane Thioparamizon Thioacetazone Thioazetazone Thiosemicarbazone Nuclon argentinian 4'-Formylacetanilide thiosemicarbazone p-Formylacetanilide-3-thiosemicarbazone p-Acetaminobenzylidenethiosemicarbazone p-Acetamidobenzaldehyde thiosemicarbazone p-Acetoaminobenzaldehyde thiosemicarbazone 4'-formyl-acetanilid4'-(thiosemicarbazone) p-Acetylaminobenzaldehyde thiosemicarbazone Acetanilide, 4'-formyl-, 4'-(thiosemicarbazone) N-[4-(carbamothioylcarbonohydrazonoyl)phenyl]acetamide Acetamide, N-[4-[[(aminothioxomethyl)hydrazono]methyl]phenyl]- Acetamide, N1-(4-{[2-(aminocarbothioyl)hydrazono]methyl}phenyl) Acetamide, N-(4-(((aminothiomethyl)hydrazono)methylene)phenyl)- N-{4-[(E)-(2-carbamothioylhydrazinylidene)methyl]phenyl}acetamide
CAS	104-06-3
EINECS	203-170-6
InChI	InChI=1/C10H12N4OS/c1-7(15)13-9-4-2-8(3-5-9)6-12-14-10(11)16/h2-6H,1H3,(H,13,15)(H3,11,14,16)/b12-6+

Molecular Formula	C10H12N4OS
Molar Mass	236.29
Density	1.2752 (rough estimate)
Melting Point	225-230 °C
Appearance	powder to crystal
Color	White to Orange to Green
pKa	11.35±0.70(Predicted)
Storage Condition	Room Temprature
Refractive Index	1.6440 (estimate)
Physical and Chemical Properties	Light yellow crystal or crystalline powder. Decomposition at 225-230 °c. Soluble in hot alcohol, slightly soluble in cold alcohol, very slightly soluble in water, insoluble in chloroform, ether, soluble in potassium hydroxide ethanol solution.
In vitro study	Thiacetazone is a prodrug that is activated by the mycobacterial monooxygenase EthA, which is also the activator of two other anti-tuberculosis agents, Ethionamide and Isoxyl.
In vivo study	The K m and V max values for the N-deacetylation of Thiacetazone are 0.57 mM and 0.123 nmol of p-aminobenzaldehydethiosemicarbazone formed/min/mg cytosolic protein, respectively. The ability to metabolize Thiacetazone is the same in the livers of cat, mouse and human, but lagged significantly in that of rat.

Hazard Symbols	Xn - Harmful
Risk Codes	22 - Harmful if swallowed
Safety Description	36 - Wear suitable protective clothing.
WGK Germany	3
RTECS	AE3850000
HS Code	29309090
Toxicity	LD50 s.c. in mice: 1-2 g/kg (Bavin)

biological activity	Thiacetazone (Thioacetazone) is an antituberculous agent containing thiourea and an orally active antibiotic. Thiacetazone has antibacterial effect and can inhibit the growth of Mycobacterium tuberculosis H37Rv (Mycobacterium tuberculosis H37Rv) with MIC value of 0.1 μg/mL.
target	MIC: 0.1 μg/mL ( Mycobacterium tuberculosis H37Rv )
use	this product can inhibit tuberculosis and leprosy, and change the morphology, particle disappearance and chromatin of the bacteria. It was first used to treat leprosy, and its effect is not as good as sulfones, but it has a good effect on tuberculosis leprosy.
Production method	It is obtained by the reaction of p-acetaminobenzaldehyde and hydrazine thiocyanate in glacial acetic acid at 104 ℃. The yield of this method is 95%.

Last Update：2024-04-09 20:13:35

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Product Name: Thiacetazone Visit Supplier Webpage Request for quotation
CAS: 104-06-3
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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Tiocarone

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