Tos-L-Phe-OH

Tos-L-Phe-OH - Names and Identifiers

Name	N-P-tosyl-L-phenylalanine
Synonyms	Tos-Phe-OH TOS-PHE-OH Tos-L-Phe-OH TOS-PHENYLALANINE-OH TOSYL-L-PHENYLALANINE N-TOSYL-L-PHENYLALANINE P-TOSYL-L-PHENYLALANINE N-P-tosyl-L-phenylalanine N-(p-Tosyl)-L-phenylalanine N-p-Toluenesulphonyl-L-phenylalanine N-(p-Toluenesulfonyl)-L-phenylalanine N-alpha-p-Toluolsulfonyl-L-phenylalanine N-[(4-methylphenyl)sulfonyl]phenylalanine N-[(4-methylphenyl)sulfonyl]-L-phenylalanine
CAS	13505-32-3
EINECS	1533716-785-6
InChI	InChI=1/C16H17NO4S/c1-12-7-9-14(10-8-12)22(20,21)17-15(16(18)19)11-13-5-3-2-4-6-13/h2-10,15,17H,11H2,1H3,(H,18,19)

Tos-L-Phe-OH - Physico-chemical Properties

Molecular Formula	C16H17NO4S
Molar Mass	319.38
Density	1.303±0.06 g/cm3(Predicted)
Melting Point	165 °C
Boling Point	517.7±60.0 °C(Predicted)
Flash Point	266.9°C
Solubility	almost transparency in hot EtOH
Vapor Presure	1.52E-11mmHg at 25°C
Appearance	powder to crystal
Color	White to Light yellow
pKa	3.31±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	-2.8 ° (C=4.5, Aceto

Tos-L-Phe-OH - Risk and Safety

Safety Description	24/25 - Avoid contact with skin and eyes.
HS Code	29224999
Hazard Class	IRRITANT

Tos-L-Phe-OH - Introduction

N-p-toluenesulfonylphenylalanine is an organic compound with the chemical formula C14H15NO4S, commonly abbreviated as N-Ts-Phe-OH. The following is a description of the properties, uses, methods and safety information of N-p-toluenesulfonylphenylalanine:

Nature:
1. Appearance: N-p-toluenesulfonylphenylalanine is usually a white or white-like crystalline solid.
2. Solubility: It has poor solubility in water, but it can be dissolved in organic solvents such as methanol, chloroform and dimethyl sulfoxide.
3. Stability: N-p-toluenesulfonylphenylalanine is relatively stable at room temperature.

Use:
1. Biochemical studies: N-p-toluenesulfonylphenylalanine can be used as synthetic peptides, proteins and peptide drugs.
2. Drug research: It can be used as a drug intermediate and has the effect of regulating biological activity.

Preparation Method:
The preparation method of N-p-toluenesulfonylphenylalanine is commonly synthesized by p-toluenesulfonylation-aminolysis reaction. The specific preparation steps are as follows:
1. N-p-toluenesulfonylbenzoate is reacted with phenylalanine in the presence of an aminolysis agent to produce N-p-toluenesulfonylphenylalanine and methyl acetate.
2. The resulting product is isolated and purified by filtration, crystallization, etc.

Safety Information:
The following safety precautions should be taken when using and handling N-p-toluenesulfonylphenylalanine:
1. because of certain toxicity, it is recommended to wear personal protective equipment during operation, such as latex gloves, goggles, etc.
2. Avoid contact with skin or inhalation of its particles to avoid allergic reactions or irritation.
3. Keep dry during storage and avoid contact with fire and oxidizing agents to prevent decomposition or fire.
4. in the use and storage process to strictly abide by the relevant chemical safety procedures.

Last Update：2024-04-09 15:17:51