Trans-ISRIB
ISRIB
CAS: 1597403-47-8
Molecular Formula: C22H24Cl2N2O4
Trans-ISRIB - Names and Identifiers
| Name | ISRIB |
| Synonyms | ISRIB CS-1768 Trans-ISRIB ISRIB - trans-ISRIB ISRIB (trans-isoMer) N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)acetamide] Acetamide, N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)- trans-N,N'-(cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide) N,N'-((1r,4r)-cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide) ISRIB(trans-isomer) |
| CAS | 1597403-47-8 |
Trans-ISRIB - Physico-chemical Properties
| Molecular Formula | C22H24Cl2N2O4 |
| Molar Mass | 451.34 |
| Density | 1.33±0.1 g/cm3(Predicted) |
| Boling Point | 719.0±60.0 °C(Predicted) |
| pKa | 13.63±0.40(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | ISRIB can inhibit the expression of endogenous ATF4, while the expression of XBP1smRNA and XBP1s is unchanged. ISRIB inhibits the balance of the endoplasmic reticulum by inhibiting the balance of estrogen receptors to inhibit the PERK signaling pathway, and reduces the survival rate of cells facing endoplasmic reticulum stress. |
| In vivo study | ISRIB has good characteristics in pharmacokinetic experiments and has good bioavailability in vivo. ISRIB injected intraperitoneally (0.25 mg/kg) in mice increased long-term memory by enhancing spatial memory and fear memory. |
Trans-ISRIB - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.216 ml | 11.078 ml | 22.156 ml |
| 5 mM | 0.443 ml | 2.216 ml | 4.431 ml |
| 10 mM | 0.222 ml | 1.108 ml | 2.216 ml |
| 5 mM | 0.044 ml | 0.222 ml | 0.443 ml |
Last Update：2024-01-02 23:10:35
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Product Name: ISRIB Visit Supplier Webpage Request for quotationCAS: 1597403-47-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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