Treprostinil
Treprostinil
CAS: 81846-19-7
Molecular Formula: C23H34O5
Treprostinil - Names and Identifiers
Treprostinil - Physico-chemical Properties
| Molecular Formula | C23H34O5 |
| Molar Mass | 390.51 |
| Density | 1.158±0.06 g/cm3(Predicted) |
| Melting Point | 121-123° |
| Boling Point | 587.1±50.0 °C(Predicted) |
| Solubility | Chloroform (Slightly, Heated), Methanol (Slightly, Heated) |
| Appearance | Solid |
| Color | Off-White to Beige |
| pKa | 3.19±0.10(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Physical and Chemical Properties | Qu Qianlianier is a chemical formula and also a drug. Tliprost mainly works by directly dilating the vascular bed of pulmonary and systemic arteries and inhibiting platelet aggregation. |
| In vitro study | Treprostinil has high affinity for the DP1, EP2 and IP receptors (K i =4.4, 3.6 and 32 nM, respectively), low affinity for EP1 and EP4 receptors and even lower affinity for EP3, FP and TP receptors. Activation of IP, DP1 and EP2 receptors, as with treprostinil, can all result in vasodilatation of human pulmonary arteries.Treprostinil inhibits viability of cultured endothelial colony forming cells. Endothelial colony forming cells proliferation is stimulated by conditioned media from Treprostinil pretreated mesenchymal stem cells. |
| In vivo study | Inhaled treprostinil sodium, a prostacyclin analog, is the most recent agent to receive FDA approval for the treatment of a fatal orphan disease: pulmonary arterial hypertension (PAH). Treprostinil preserves the sinusoidal endothelial cell lining and reduces platelet deposition early post-transplantation compared to placebo. Hepatic tissue blood flow is significantly compromised in the placebo group, whereas treprostinil maintains blood flow similar to normal levels.Treprostinil treatment significantly increases the vessel-forming ability of endothelial colony forming cells combined with mesenchymal stem cells in Matrigel implanted in nude mice. Silencing VEGF-A gene in mesenchymal stem cells also blocks the pro-angiogenic effect of Treprostinil. Treprostinil is most efficacious in raising intracellular cAMP levels in murine and human hematopoietic stem and progenitor cells. Treatment with Treprostinil significantly reduces the recruitment of cells compared to normoxic mice. Treprostinil also reduces right ventricular systolic pressure and slightly reduces the vascular remodelling but fails to reverse the right ventricular hypertrophy. |
Treprostinil - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.561 ml | 12.804 ml | 25.608 ml |
| 5 mM | 0.512 ml | 2.561 ml | 5.122 ml |
| 10 mM | 0.256 ml | 1.28 ml | 2.561 ml |
| 5 mM | 0.051 ml | 0.256 ml | 0.512 ml |
Last Update：2024-01-02 23:10:35
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Multiple SpecificationsSpot supply
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Tel: 609-228-6898
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Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
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Product Name: Treprostinil Visit Supplier Webpage Request for quotation
CAS: 81846-19-7
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Email: 3008007409@qq.com
Mobile: 18021002903
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CAS: 81846-19-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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View History
Treprostinil
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