Trijodmethane
Iodoform
CAS: 75-47-8
Molecular Formula: CHI3
Trijodmethane - Names and Identifiers
| Name | Iodoform |
| Synonyms | CHIT IODOFORM Iodoform Trijodmethan Trijodmethane triiodo-methan Triiodomethane triiodomethane(iodoform) chitinase 1 (chitotriosidase) Anti-CHIT1 antibody produced in goat |
| CAS | 75-47-8 |
| EINECS | 200-874-5 |
| InChI | InChI=1/CHI3/c2-1(3)4/h1H |
Trijodmethane - Physico-chemical Properties
| Molecular Formula | CHI3 |
| Molar Mass | 393.73 |
| Density | 4.008g/mLat 25°C(lit.) |
| Melting Point | 119 °C |
| Boling Point | 218°C |
| Flash Point | 129°C |
| Water Solubility | Insoluble. |
| Solubility | chloroform: soluble5% |
| Vapor Presure | 0.0339mmHg at 25°C |
| Appearance | Crystalline Powder |
| Color | Bright yellow to dark yellow |
| Exposure Limit | ACGIH: TWA 0.6 ppmNIOSH: TWA 0.6 ppm(10 mg/m3) |
| Merck | 14,5033 |
| BRN | 1697010 |
| Storage Condition | -20°C |
| Stability | Stable. Incompatible with strong oxidizing agents, reducing agents. May explode when heated. |
| Sensitive | Light Sensitive |
| Refractive Index | 1.4975 (estimate) |
| Physical and Chemical Properties | Density 4.008 melting point 119-122°C boiling point 218°C water-soluble Insoluble. <0.1g/100 mL at 24°C |
| Use | Used as a preservative |
Trijodmethane - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| UN IDs | UN 1851 |
| WGK Germany | 3 |
| RTECS | PB7000000 |
| FLUKA BRAND F CODES | 13 |
| TSCA | Yes |
| HS Code | 29033990 |
| Toxicity | LD50 s.c. in mice: 1.6 mmoles/kg (Kutob, Plaa) |
Trijodmethane - Upstream Downstream Industry
| Raw Materials | Acetone Sodium hydroxide |
Trijodmethane - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| pharmacological action | iodoform also known as triiodomethane, chi3. Iodoform has a strong bactericidal effect of Disinfection (can release the migration of iodine), and inhibit wound secretions, prevent the growth of bacteria, it is mainly used for the preparation of skin disease topical ointment (oral toxic) and fungicides. Iodoform is an organic iodine compound, which can slowly decompose and dissociate iodine after contact with organic matter and bacterial oxidase contained in tissue fluid, blood, secretion and pus, showing bactericidal effect. Dry powder has little irritation on tissue, and can absorb exudate, keep the wound dry, and promote granulation tissue regeneration and wound healing. |
| indication | It is used for sterilization and deodorization of infected wounds, with long-lasting effect and no irritation. Iodoform ointment, iodoform glycerin, iodoform paste can be directly used for purulent inflammation, can also be used for root canal therapy and arsenic periodontal necrosis or arsenic periapical periodontitis; Iodoform gauze for dry socket alveolar, after the operation, the maxillary sinus was infected, and the dead cavity was filled after the abscess cavity was discharged. The iodoform sponge and iodoform calcium hydroxide paste were also used for pulp cutting. |
| adverse reactions | long-term application on a large area of the wound, iodine absorption can cause systemic poisoning symptoms. Local wound application, the total amount of not more than 2G, occasionally allergic, may appear erythema rash, severe cases can cause Head Pain, drowsiness, Coma and so on. |
| Use | is used as a preservative and disinfectant in medicine and biochemistry. Oral LD50 in mice was 910mg/kg. |
| production method | from acetone (or ethanol) by halogenation, hydrolysis. Water, sodium iodide and acetone were first added to the reaction pan, and ice was added to cool to 10 °c. Sodium hypochlorite was slowly added with stirring until the end point was reached without turbidity and the temperature was controlled not to exceed 20 °c. The mixture was allowed to stand for 1H, the supernatant was removed by suction, and the iodoform layer was removed and filtered. The filter cake was washed with water until neutral and then with distilled water until free of chloride. The other 35-40 °c was then dried to obtain the finished product. In addition, this product can also be prepared by the reaction of chloroform with methyl iodide. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:11:58
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Raw Materials for Trijodmethane