Name | Choline fenofibrate |
Synonyms | ABT-335 Abt 335 ABT 335 Trilipix Unii-4bmh7izt98 UNII-4BMH7IZT98 Choline Fenofibrate Choline fenofibrate Fenofibrate de choline Fenofibrate Impurity 8(Choline Fenofibrate) 2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropanoic acid 2-hydroxy-N,N,N-trimethyl, 2-{4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate 2-hydroxy-N,N,N-trimethylethanaminium 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate 2-Hydroxy-N,N,N-trimethylethanaminium 2-(-(4-chlorobenzoyl)phenoxy)-2- methylpropanoate 2-Hydroxy-N,N,N-triMethylethanaMiniuM 2-[4-(4-chlorobenzoyl)phenoxy]-2-Methylpropanoate |
CAS | 856676-23-8 |
InChI | InChI=1/C17H15ClO4.C5H14NO/c1-17(2,16(20)21)22-14-9-5-12(6-10-14)15(19)11-3-7-13(18)8-4-11;1-6(2,3)4-5-7/h3-10H,1-2H3,(H,20,21);7H,4-5H2,1-3H3/q;+1/p-1 |
Molecular Formula | C22H28ClNO5 |
Molar Mass | 421.91442 |
Melting Point | 210-212°C |
Boling Point | 486.5°C at 760 mmHg |
Flash Point | 248°C |
Solubility | Methanol (Slightly), Water (Slightly) |
Vapor Presure | 2.82E-10mmHg at 25°C |
Appearance | Solid |
Color | White to Off-White |
Storage Condition | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
Stability | Hygroscopic |
HS Code | 2923100000 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.37 ml | 11.851 ml | 23.702 ml |
5 mM | 0.474 ml | 2.37 ml | 4.74 ml |
10 mM | 0.237 ml | 1.185 ml | 2.37 ml |
5 mM | 0.047 ml | 0.237 ml | 0.474 ml |
Overview | fenofibrate choline is a metabolic compound of fenofibrate. Fenofibrate belongs to the fibrate class of drugs that reduce low density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels, as well as increase high density lipoprotein (HDL) levels and decrease triglyceride levels. |
emergency measures | if inhaled fenofibrate choline, move the patient to fresh air; If skin contact, should remove contaminated clothing, with soap and water thoroughly rinse the skin, if there is discomfort, medical treatment; If the eyes contact, should separate the eyelids, with running water or saline, and immediately seek medical treatment; if the food, immediately gargle, prohibit emetic, should immediately see a doctor. |
biological activity | Choline fenofibrate is a Choline salt of fenofibric acid, fenofibric acid is a synthetic phenoxyisobutyric acid derivative with antihyperlipidemic activity and is a PPAR alpha agonist. |
Target | PPAR |
Animal Model: | Male Sprague-Dawley (SD) rats (200-250g) |
Dosage: | 4 mg/kg (Pharmacokinetic Analysis) |
Administration: | Intravenous injection and oral administration |
Result: | Oral bioavailability (93.4%), C max (7944.2 ng/mL), T 1/2 (5.4 h). |