Trimethylorthoaceate

Trimethylorthoaceate - Names and Identifiers

Name	1,1,1-Trimethoxyethane
Synonyms	TMOA CH3C(OCH3)3 trimethyl-acetate Methyl orthoacetate Trimethylorthoaceate 1,1,1-triethoxyethane 1,1,1-trimethoxy-ethan 1,1,1-Trimethoxyethane Trimethyl orthoacetate TRIMETHYL ORTHOACETATE Trimethyl Orthoacetate (TMOA) ORTHOACETIC ACID TRIMETHYL ESTER
CAS	1445-45-0
EINECS	215-892-9
InChI	InChI：1S/C5H12O3/c1-5(6-2,7-3)8-4/h1-4H3
InChIKey	HDPNBNXLBDFELL-UHFFFAOYSA-N

Trimethylorthoaceate - Physico-chemical Properties

Molecular Formula	C5H12O3
Molar Mass	120.15
Density	0.944g/mLat 25°C(lit.)
Boling Point	107-109°C(lit.)
Flash Point	62°F
Water Solubility	HYDROLYSIS
Vapor Presure	20 hPa (20 °C)
Appearance	Liquid
Specific Gravity	0.960 (20/4℃)
Color	Clear colorless to slightly brown
BRN	1098338
Storage Condition	Store below +30°C.
Sensitive	Moisture Sensitive
Refractive Index	n20/D 1.388(lit.)
Physical and Chemical Properties
Use	Mainly as the production of pharmaceutical and pesticide chemical intermediates. For the synthesis of vitamin B1, vitamin A1, sulfamidine and other pharmaceutical intermediates, can also be used in dyes and spices industry. Pharmaceutical, home Chemical, can also be used in the dye and fragrance industry. Pharmaceutical, agricultural chemical, paint additives.

Trimethylorthoaceate - Risk and Safety

Risk Codes	R11 - Highly Flammable R43 - May cause sensitization by skin contact R38 - Irritating to the skin R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S16 - Keep away from sources of ignition. S37/39 - Wear suitable gloves and eye/face protection S24 - Avoid contact with skin. S33 - Take precautionary measures against static discharges. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S7/9 -
UN IDs	UN 3272 3/PG 2
WGK Germany	1
TSCA	Yes
HS Code	29159080
Hazard Class	3
Packing Group	II
Toxicity	LD50 orally in Rabbit: > 2000 mg/kg

Trimethylorthoaceate - Reference Information

LogP	1.13 at 25℃
NIST chemical information	information provided by: webbook.nist.gov (external link)
EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
Use	trimethyl ortho-acetate is an important intermediate for the synthesis of methyl dichloro-urate. is used for the production of pharmaceutical, pesticide intermediates, but also the production of food additives, coatings, paints and other main raw materials. is used for the production of pharmaceutical, pesticide intermediates, but also the production of food additives, coatings, paints and other main raw materials, used as organic synthesis reagents.
production method	the preparation method is to add anhydrous acetonitrile, methanol and carbon tetrachloride in the reaction pot, cooling to -10 °c, with stirring, into the dry HCl gas, after passing the HCl, slowly warmed to 0~5 °c, continue to stir at this temperature for 12h, the reaction mixture of crude imino ether hydrochloride was neutralized with 28% sodium methoxide methanol solution to pH = 6.5, then added with pre-cooled methanol for alcoholysis, and the temperature was controlled at 5 ℃, then the temperature was raised to 35~40 ℃, the reaction was continued to stir for 10h, then cooled to 0~5 ℃, ammonium chloride was removed by Suction filtration, and the filtrate was neutralized with 28% sodium methoxide methanol solution to adjust pH = 8, then filtration, and then distillation, first remove the solvent carbon tetrachloride, and then collect 107~110 deg C fraction of trimethyl orthoacetate, the yield can reach 90%.

Last Update：2024-04-09 20:49:11

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Trimethylorthoaceate

1,1,1-Trimethoxyethane

CAS: 1445-45-0

Molecular Formula: C5H12O3

Trimethylorthoaceate - Names and Identifiers

Trimethylorthoaceate - Physico-chemical Properties

Trimethylorthoaceate - Risk and Safety

Trimethylorthoaceate - Reference Information

Supplier List

Trimethylorthoaceate Request for Quotation

1,1,1-Trimethoxyethane

CAS: 1445-45-0

Molecular Formula: C5H12O3

Trimethylorthoaceate - Names and Identifiers

Trimethylorthoaceate - Physico-chemical Properties

Trimethylorthoaceate - Risk and Safety

Trimethylorthoaceate - Reference Information

Supplier List

Trimethylorthoaceate