Trimethylsilyltrichloroacetate

Trimethylsilyltrichloroacetate - Names and Identifiers

Name	Trimethylsilyltrichloroacetate
Synonyms	Trimethylsilyltrichloroacetate Trimethylsilyl trichloroacetate TRIMETHYLSILYL TRICHLOROACETATE (trichloroacetyloxy)trimethylsilane Trichloroacetic acid trimethylsilyl ester 2,2,2-Trichloro-Acetic Acid Trimethylsilyl Ester Acetic acid,2,2,2-trichloro-, trimethylsilyl ester
CAS	25436-07-1
EINECS	246-980-5
InChI	InChI=1/C5H9Cl3O2Si/c1-11(2,3)10-4(9)5(6,7)8/h1-3H3

Trimethylsilyltrichloroacetate - Physico-chemical Properties

Molecular Formula	C5H9Cl3O2Si
Molar Mass	235.57
Density	1.245g/mLat 25°C(lit.)
Boling Point	70-73°C12mm Hg(lit.)
Flash Point	28°C
Vapor Presure	0.723mmHg at 25°C
Specific Gravity	1.237
Sensitive	7: reacts slowly with moisture/water
Refractive Index	n20/D 1.44(lit.)

Trimethylsilyltrichloroacetate - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R10 - Flammable R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
UN IDs	UN 3272 3/PG 3
WGK Germany	3
FLUKA BRAND F CODES	10-21
TSCA	No
Hazard Class	3.2
Packing Group	III

Trimethylsilyltrichloroacetate - Introduction

Is an organosilicon compound with the formula (CH3) 3siccl3o. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: colorless liquid
-Melting point:-70 ℃
-Boiling point: 65-70 ℃
-Density: 1.324 g/mL
-Solubility: Soluble in some organic solvents, such as ether, methanol and acetone

Use:
-As a reagent in Organic Synthesis: It can be used as an acid catalyst, reagent and protecting group in organic synthesis.
-Protect the hydroxyl functional group: It can react with the hydroxyl group to generate an esterification product, thereby protecting the hydroxyl functional group.
-Methylating reagent: It can methylate electrophilic groups for alkylation reactions in organic synthesis.

Method:
It can be obtained by reacting trimethylsilyl chloromethyl ether ((CH3) 3Sioch3) with chloroacetic acid.

Safety Information:
-is an organic compound and should be used with care. It may irritate the skin, eyes and mucous membranes, so you should wear protective equipment to avoid contact with skin, eyes and respiratory tract.
-During storage and use, prevent contact with oxygen to avoid possible combustion and explosion.

Please note that the above information is for reference only. When using calcium, follow proper laboratory procedures and closely follow relevant safety precautions and technical data sheets.

Last Update：2024-04-10 22:29:15