Trisilicalm
Magnesium trisilicate
CAS: 14987-04-3
Molecular Formula: H8MgOSi
Trisilicalm - Names and Identifiers
Trisilicalm - Physico-chemical Properties
| Molecular Formula | H8MgOSi |
| Molar Mass | 76.45 |
| Water Solubility | insoluble H2O, EtOH [CRC10] |
| Solubility | Practically insoluble in water and in ethanol (96 per cent). |
| Appearance | White powder |
| Color | White |
| Merck | 14,5687 |
| Storage Condition | Room Temprature |
| Sensitive | Easily absorbing moisture |
| MDL | MFCD00016203 |
| Physical and Chemical Properties | White fine powder, odorless, tasteless, no gravel feeling. |
| Use | Used for neutralizing gastric acid, antacid, used in ceramics, rubber industry as filler, food industry as anti-caking agent, filter aid, film coating agent |
Trisilicalm - Risk and Safety
| WGK Germany | 3 |
| RTECS | IN6620000 |
| TSCA | Yes |
Trisilicalm - Upstream Downstream Industry
| Raw Materials | Magnesium sulfate anhydrous |
Trisilicalm - Nature
Open Data Verified Data
White fine powder. Odorless and tasteless. Insoluble in water and ethanol. When the inorganic acid is easy to decompose, slightly hygroscopic.
Last Update：2024-01-02 23:10:35
Trisilicalm - Preparation Method
Open Data Verified Data
sodium hydroxide, sodium hydroxide and magnesium sulfate were pretreated and reacted to form a magnesium trisilicate precipitate, which was rinsed, filtered, dried and pulverized to obtain a magnesium trisilicate product.
Last Update：2022-01-01 09:04:46
Trisilicalm - Standard
Authoritative Data Verified Data
This product is a magnesium silicate hydrate of indefinite composition (Mg2Si30 • «H 20). Containing M g () not less than 20.0%, containing SiO;! Not less than 45. 0%, the ratio of SiOz and M g () content should be 2. 1~2 .3.
Last Update：2024-01-02 23:10:35
Trisilicalm - Trait
Authoritative Data Verified Data
- This tablet is A color or off-white powder; Odorless, 1 Tasteless; Slightly hygroscopic.
- This product is insoluble in water or ethanol.
Last Update：2022-01-01 11:20:09
Trisilicalm - Introduction
Odorless, tasteless, slightly hygroscopic. Water-containing magnesium silicate with variable composition. Easily decomposed by inorganic acids. Insoluble in water and ethanol.
Last Update：2022-10-16 17:14:05
Trisilicalm - Use
Open Data Verified Data
It is used as an antacid in medicine. Can neutralize gastric acid and protect the ulcer surface, the effect is slow and lasting. Can be used as a deodorant, decolorizing agent, also used in ceramics, rubber and other industries. Food grade used as anti-caking agent, filter aid, film agent. Fillers in dairy products.
Last Update：2022-01-01 09:04:47
Trisilicalm - Differential diagnosis
Authoritative Data Verified Data
- Several crystals of sodium ammonium phosphate are dipped with a platinum wire ring and fused into a transparent pellet on a colorless flame. Then, the product is dipped hot and melted as before, silica is floating on the surface of the small ball, cool, that is, the network structure of the opaque small ball.
- take about 0. 5 g of this product, Add 10ml of dilute hydrochloric acid, mix, filter, and neutralize the filtrate with ammonia test solution. Identify the reaction of magnesium salt (2 )(General 0301).
Last Update：2022-01-01 11:20:09
Trisilicalm - Safety
Open Data Verified Data
ground glass bottle packaging, sealed with wax. The net weight of each bottle was 1kg, and then packed into wooden cases, 10 bottles per box. When used as chemical raw materials, polyethylene plastic bags are used for packaging, and then Kraft paper bags or woven bags are used for packaging. Store in a cool, ventilated, dry place. It should be protected from moisture and rain during transportation. It should not be stored and mixed with acids. When loading and unloading, handle with care, vibration is strictly prohibited to prevent bottle breakage. In case of fire, it can be suppressed by water and various fire-retardants.
Last Update：2022-01-01 09:04:47
Trisilicalm - Exam
Authoritative Data Verified Data
particle size and particle size distribution
(when used as a glidant, check this item) take this product, according to the particle size and particle size distribution determination method (General Rule 0 9 8 2 third method) determination, with laser scattering particle size distribution analyzer, water was used as the dispersant, and the wet method was used. Particle size greater than 250PM should not exceed 6%.
Acid Control Force
take this product about 0.3 0G, precision weighing, put the plug Erlenmeyer flask, precision plus hydrochloric acid titration solution (0. lm o l/L) and water 50ml each, place in 37°C water bath for 2 hours (should always shake, but the last 15 minutes should be static), cool; tip density take the supernatant 50ml, add methyl orange indicator solution 1 drop, with sodium hydroxide titration solution (0. lm o l/L) titration of the remaining hydrochloric acid solution. The consumption of hydrochloric acid titrant (0. lm o l/l) should be 140 ~ 170ml per L g calculated as the fulgant.
free Base
take 4.0g of this product, add water 6 0 m l, boil for 15 minutes, filter with 2~3 layers of filter paper, wash with water, combine the wash and filtrate, put it in a 100ml measuring flask, dilute it to the scale with water, and shake it well; Take 25ml with precision, add 2 drops of phenolphthalein indicator solution, if it is light red, add hydrochloric acid titration solution (0. lm o l/L )1 .0 m l, light red should disappear.
chloride
take this product l .O g, add nitric acid 4m l and water 4ml, heat and boil, always shake, add water 20 m l, shake, cool, filter, filter, wash with a small amount of water, the washing liquid and the filtrate were combined, placed in a 50ml measuring flask, diluted with water to the scale, and shaken to be used as a test solution. Take 5ml with precision and check according to law (General Rule 0 8 0 1). Compare with the control solution made of 5. 0ml of standard gasification sodium solution, it should not be more concentrated (0.05%).
sulfate
take 5ml of the test solution under the gasification item, add water 30 m l, check according to law (General Rule 0 8 0 2 ) , and standard potassium sulfate solution 5. Compared with the control solution made of 0 M l, it should not be more concentrated (0 .5%).
soluble salts
2 5 m l of the filtrate remaining under the above item of free base was accurately measured, evaporated to dryness, and burned to constant weight. The remaining residue should not exceed 15mg.
ignition weight loss
take about 800g of this product, weigh it accurately, burn to constant weight at 7 0 0 ~ 0.0% °C, and lose no more than weight.
Heavy metals
take this product 3. 0g, add 5ml hydrochloric acid and 40ml water, boil for 20 minutes, let cool, add 2 drops of phenolphthalein indicator solution, add concentrated ammonia test solution until the solution is pink, then add 0. lm o l/L hydrochloric acid solution lm l makes it slightly acidic: filter, wash the filter residue with a small amount of water in several times, combine the wash solution and the filtrate, add ammonia test solution Dropwise until the solution is pink, add 0. lm o l/L hydrochloric acid solution (8M l) was mixed with appropriate amount of water to 0821, then the mixture was shaken, and z5m l was collected for inspection according to law (General rules, law 1), heavy metals should not be more than 20 parts per million.
mercury salt
take this product l. Two aliquots of O g were placed in a 25ml measuring flask, and 6mL of hydrochloric acid was added in one aliquot. The magnesium oxide was dissolved by shaking, wash the residue with a small amount of hydrochloric acid solution (6-25), combine the filtrate and washing solution, put it in a 50ml measuring flask, add 0.5ml of 5% potassium permanganate solution, and shake it well, 5% hydroxylamine hydrochloride solution was added dropwise until the purple color disappeared, and diluted to the scale with hydrochloric acid solution (6-25) as the test solution; another 5ml of precision-added mercury standard solution (an appropriate amount of mercury standard solution was quantitatively diluted with water to make a solution containing 0.1Fg of mercury per LML) was used in the same method as the reference solution, actinic Atomic Absorption Spectrophotometry (General rule 0406, second method). In 253. The test solution and the reference solution were measured at the wavelength of 6nm, and the provisions (0.000 05%) should be met.
arsenic salt
Take 20ml of the test solution under the gasification item, add 5ml of hydrochloric acid, add 3ml of water, and check according to law (General Principles 0822 first law), should comply with the regulations (0. 0005%)
Last Update：2022-01-01 11:20:10
Trisilicalm - Content determination
Authoritative Data Verified Data
magnesium oxide
take this product 1 .5G, precision weighing, precision plus sulfuric acid titration solution (0.5mol/L)50ml, put on water bath heating for 15 minutes, cold, add methyl orange indicator solution 1 drop, titration with sodium hydroxide titrant (lm o l/L). Each l of sulfuric acid titrant (0.5 mol/L) corresponds to 20.15 mg of MgO.
silica
take 0.4g of this product, precise weighing, put it in a porcelain dish, add 3M l sulfuric acid and 5m l nitric acid mixture, until the effect is complete, put the sand bath to dry, and let it cool, add 10ml of dilute sulfuric acid and 100ml of water, boil to dissolve magnesium salt, filter the upper layer through ashless filter paper, wash the residue with hot water for 3 times, filter the washing solution together, and finally shift the residue on the filter paper, after washing with hot water, the residue and the filter paper were placed in a platinum crucible, dried, burned and ash, then burned for 30 minutes, allowed to cool, and accurately weighed. Then wet the residue with water, add 3M l of hydrofluoric acid and 3 drops of sulfuric acid, steam dry, burn for 5 minutes, let cool, accurately weigh, reduce the weight of the loss, that is, the weight of 0 2 in the test volume.
Last Update：2022-01-01 11:20:11
Trisilicalm - Category
Authoritative Data Verified Data
pharmaceutical excipients, glidants, anti-adhesion agents, suspending agents, adsorbents and filter aids.
Last Update：2022-01-01 11:20:11
Trisilicalm - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 11:20:11
Trisilicalm - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| overview | magnesium trisilicate, also known as "magnesium orthosilicate". The chemical formula is Mg 2 Si 3 O 8 nH 2 O, white orthorhombic crystal, melting point 1910 ℃, relative density 3.21 this product is insoluble in water or ethanol. Decomposition in concentrated alkali to generate Mg(OH)2, decomposition in hot hydrochloric acid to generate silicic acid and magnesium chloride, which can be decomposed by hydrofluoric acid. Forsterite minerals exist in nature. Due to the openness of the crystal structure of this product, it contains cavities and pores that penetrate each other and are connected to the outside world. It has a more developed pore structure and a large specific surface area, so it has better adsorption performance and molecular sieve function. It can provide specific molecular field force. In medicine, it can neutralize gastric acid. Although its effect is weak, it is slow and lasting, up to 4~5 hours. It is suitable for the treatment of gastric and duodenal ulcers, relieve symptoms caused by hyperacidity. In addition, it can also be used as processing aid and polyether adsorbent, which has the function of adsorption and decolorization. Because this product has broad application prospects in the fields of pharmaceutical intermediates, food additives, rubber fillers, deodorants and ceramic industries. Therefore, it has received increasing attention. |
| preparation process | Na2O · nSiO2 solution and Mg(NO3)2 solution with a certain concentration are respectively prepared by using foam alkali with a chemical pure modulus of 3.34 and chemically pure Mg(NO3)2 as raw materials. According to n(Si): n(Mg)= 2: 1, the Mg(NO3)2 solution is dripped into the N a2O · nSiO2 solution at a speed of 5 mL /min, and stirred at the same time. After mixing, white precipitate is obtained. After dropping, the mixed solution is still aged for 1.0 h, then filtered, washed and precipitated to neutral, and dried in an oven to obtain this product. |
| pharmacological action | this product is an antacid agent with slow and lasting action, no gas generation, can protect gastric mucosa, and has laxative and adsorption effects. Insoluble in water, can absorb free acid in the stomach and play the role of acid production. The effect of neutralizing gastric acid is weak, but it is slow and lasting, up to 4~5h. The laxative effect of magnesium-containing acids can lead to defecation. About 10% of magnesium can be absorbed from the intestine. When neutralizing gastric acid, it does not produce carbon dioxide and produces colloidal silica, which covers the surface of the ulcer and has a protective effect. And can adsorb intestinal endotoxins, bacteria and harmful gases. Large doses have a laxative effect. It is clinically used for hyperacidity and peptic ulcer. |
| use | this product is an antacid agent, which can neutralize gastric acid. its effect is slow and lasting, but it is slow and lasting, up to 4~5h, does not produce gas, can protect gastric mucosa, and has laxative and adsorption effects. It is suitable for treating stomach and duodenal ulcer and relieving symptoms caused by hyperacidity. It is used as an antacid in medicine. It can neutralize gastric acid and protect the ulcer surface, and its effect is slow and long-lasting. Can be used as deodorant and decolorant, etc. It can also be used in ceramic and rubber industries. Food grade is used as anti-caking agent, filter aid, coating agent. According to FAO/WHO(1984), the maximum amount of anti-caking agent used in powdered dairy products (milk powder, cream powder, high-fat milk powder, semi-cream powder) is 10 g/kg. It is used as a neutralizing acid agent and antacid agent, used in ceramics and rubber industry as a filler, and used in food industry as an anti-caking agent, filter aid, coating agent, etc. odor absorbent. decolorant. Antioxidant. TLC adsorbent. Column chromatography adsorbent. |
| adverse reactions | long-term use of this product may cause renal tubular silicon stones, thus damaging renal tubules. Therefore, when used to treat gastric ulcers, attention should be paid to its potential toxicity. Patients with renal insufficiency or long-term large-scale use may experience dizziness, convulsions, arrhythmia or mental symptoms, as well as abnormal fatigue. |
| precautions | 1. those who are allergic to this product are prohibited. 2. Children should use it with caution. 3. Use with caution during the first 3 months of pregnancy. 4. When combined with atropine, digoxin, diazepam, and isoniazid drugs, the effect of the latter is affected by reduced absorption; when combined with levodopa, absorption may increase; chlorpromazine drugs can Inhibit the absorption of this product. |
| production method | metathesis method pretreatments sodium and magnesium sulfate to react to generate magnesium trisilicate precipitate, which is rinsed, filtered, dried and crushed to produce magnesium trisilicate finished products. Its 2 Na2O · 3 SiO2 · 5H2O 2MgSO4 → this product 2Na2SO4 |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
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Raw Materials for Trisilicalm