Tulobuterol
Tulobuterol
CAS: 41570-61-0
Molecular Formula: C12H18ClNO
Tulobuterol - Names and Identifiers
Tulobuterol - Physico-chemical Properties
| Molecular Formula | C12H18ClNO |
| Molar Mass | 227.73 |
| Density | 1.098±0.06 g/cm3(Predicted) |
| Melting Point | 89-91°C |
| Boling Point | 338.2±27.0 °C(Predicted) |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 13.62±0.20(Predicted) |
| Storage Condition | -20°C Freezer |
| In vivo study | In vivo effect of Tulobuterol is examined the on the contractility of diaphragm muscles prepared from mice (BALBs/c mice; 21.7 ± 0.2 g) treated with Endotoxin. Contractile parameters of force-frequency curves and twitch kinetics using untreated or treated diaphragm muscles at 0 (E0) and 4 (E4) hours after E. coli endotoxin (20 mg/kg) administration are measured. E0 and E4 diaphragm muscles are analyzed at 0, 12, and 24 h after transdermal Tulobuterol treatment. The force-frequency curves of E0 and E4 diaphragm muscles at three time points are not significantly changed each other, indicating that Tulobuterol patch restores the muscle contractility. Thus, diaphragm muscle contractility is maintained during 4 h of endotoxin administration with Tulobuterol patch for over 24 h. |
Tulobuterol - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| RTECS | DA4734170 |
| HS Code | 29214990 |
| Toxicity | LD50 in male mice, rats, rabbits (mg/kg): 305, 850, 563 orally; 170, 417, 164 s.c. (Kubo, 1975) |
Tulobuterol - References
| biological activity | Tulobuterol (C-78 free base) is a long-acting β2-adrenoceptor agonist, can reduce the frequency of attacks of chronic obstructive pulmonary disease and bronchial asthma. Tulobuterol is also a sympathomimetic used as a transdermal patch to increase normal diaphragm muscle strength. |
| Target | β2-adrenoceptor |
| Cell Line: | Human tracheal epithelial cells infected with RV14 |
| Concentration: | 0.1 μM |
| Incubation Time: | 24 hours or 72 hours |
| Result: | Decreased the RV14 RNA levels at 1 day and at 3 days after infection. The concentrations of sICAM-1 in the supernatants of the cells were significantly lower. Reduced the number of acidic endosomes with green fluorescence in the cells and the fluorescence intensity of acidic endosomes in the cells. Also reduced the RV14 infection-induced secretion of IL-1β, IL-6, and IL-8. And produced a small but significant reduction in the amount of p50, p65, and c-Rel of NF-κB induced by RV14 infection. |
Last Update：2024-04-09 21:04:16
