Typhaneoside
Typhaneoside
CAS: 104472-68-6
Molecular Formula: C34H42O20
Typhaneoside - Names and Identifiers
Typhaneoside - Physico-chemical Properties
| Molecular Formula | C34H42O20 |
| Molar Mass | 770.69 |
| Density | 1.73±0.1 g/cm3(Predicted) |
| Melting Point | >187°C (dec.) |
| Boling Point | 1065.0±65.0 °C(Predicted) |
| Specific Rotation(α) | -58 (c, 1.3 in MeOH) |
| Flash Point | 332.6°C |
| Solubility | Easily soluble in water, methanol, soluble in ethanol, slightly soluble in acetone, ethyl acetate, etc. |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Yellow crystalline powder |
| Color | Black |
| pKa | 6.17±0.40(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.716 |
| MDL | MFCD07783986 |
| Physical and Chemical Properties | Yellow crystalline powder, easily soluble in methanol, derived from Puhuang. |
Typhaneoside - Risk and Safety
| HS Code | 29389090 |
Typhaneoside - Reference
| Reference Show more | 1. Liu Yaping, Gao Mingliang, Chen Peidong, Zhou Guisheng. Study on Sieving and Cleaning of Puhuang [J]. China Medical Herald, 2020,17(34):26-29. 2. Jiang Meifang, Gao Qi, Wang Dandan. Determination of Integrated Dissolution of Terpene Lactone and Flavonoid Glycosides in Ginkgo Ketone Ester Tablets [J]. Chinese patent medicine, 2020,42(10):2716-2719. 3. Gao, Mingliang, et al. "Evaluation of VEGF mediated pro-angiogenic and hemostatic effects and chemical marker investigation for Typhae Pollen and its processed product." Journal of Ethnopharmacology 268 (2021): 113591.https://doi.org/10.1016/j.jep. 2020.113 4. [IF=4.411] Mingliang Gao et al."Chemical Property Changes and Thermal Analysis during the Carbonizing Process of the Pollen Grains of Typha."Molecules. 2019 Jan;24(1):128 5. [IF=4.36] Mingliang Gao et al."Evaluation of VEGF mediated pro-angiogenic and hemostatic effects and chemical marker investigation for Typhae Pollen and its processed product."J Ethnopharmacol. 2021 Mar;268:113591 6. [IF=4.098] Gao Ming-Liang et al."A gradient-based discriminant analysis method for process quality control of carbonized TCM via Fourier transform near infrared spectroscopy: A case study on carbonized Typhae Pollen."Spectrochim Acta A. 2022 Jan;265:120363 7. [IF=5.34] Mingliang Gao et al."Discovery of processing-associated Q-marker of carbonized traditional Chinese medicine: an integrated strategy of metabolomics, systems pharmacology and in vivo high-throughput screening model."PHYTOMEDICINE. 2022 May;:154152 |
Typhaneoside - Reference Information
| background | cattail neoglycoside (Typhaneoside) is one of the main flavonoids in cattail yellow. Typha plants grow in ponds, watersides or shallow swamps. There are 18 species in the world, and there are about 10 species in my country. The resources are extremely rich. Pu Huang, also known as Pu stick pollen, Pu Cao Huang is a plant of the cattail family (Typhaceae), water candle cattail cattail (TyphaangustifoliaL.), Oriental cattail (TyphaorientalisPresl.) or dry pollen of the same genus. It has the functions of stopping bleeding, removing blood stasis, and draining. It is used for vomiting blood, metrorrhagia, traumatic bleeding, dysmenorrhea, and bloody pain. Puhuang mainly contains steroids, flavonoids, long-chain fatty hydrocarbons, acidic components, amino acids, inorganic components, etc. Among them, flavonoids have the effects of improving microcirculation, reducing oxygen consumption in heart and brain tissues, dilating blood vessels, promoting coagulation, anti-inflammatory, induced labor, reducing blood lipids and anti-atherosclerosis. |
| preparation | 2kg of cattail yellow is put into the extraction kettle of the supercritical extraction device, and supercritical CO2 is used as solvent for supercritical extraction of cattail yellow. the extraction pressure is 28MPa, the temperature is 45 ℃, the extraction time is 3 hours, and the CO2 flow rate is 25L/h, after the environment in the extraction tank is stable, add 65% acetone carrier (20% of the amount of medicinal materials) to the carrier tank, adjust the temperature of the analytical axe to 55 ℃ and the pressure to 8MPa, and collect the extract released from the discharge port of the analytical kettle. The extract was extracted with n-butanol and concentrated under reduced pressure to obtain 244g of extract. Take 50g of extract and add silica gel (extract: silica gel = 1:3), stir evenly, dry at low temperature, then load the column with new silica gel, mix the sample silica gel on the column, and perform gradient elution according to the volume ratio of 9: 1, 7: 1, 4: 1, 2: 1, 1: 1, 1: 2, and the dosage of each gradient eluent is 200ml, the elution flow rate is 4ml/min, each part of the eluent is collected, TLC is followed up and monitored, the stream of cattail new glycosides is collected, the crude cattail new glycosides are concentrated under reduced pressure to obtain crude cattail new glycosides, the crude products are prepared into a solution with methanol concentration of 10 mg/ml, purified by preparative high performance liquid chromatography, the main component peak is collected, rotary evaporation concentration, vacuum freeze drying, and the pure cattail new glycosides 264mg is obtained. The conditions for preparing the high performance liquid chromatograph are as follows: the column packing is decadyl silane bonded silica gel, the column temperature is room temperature, the mobile phase is methanol: 0.1% acetic acid aqueous solution = 18: 32 (volume ratio), the flow rate is 5ml/min, and the detection wavelength is 254nm. |
| Biological activity | Typhaneoside, extracted from cattail (Typha angustifolia L.), can inhibit excessive autophagy (autophagy) of hypoxia/reoxygenation cells and increase phosphorylation of Akt and mTOR. Typhaneoside has certain effects on the cardiovascular system, including reducing blood lipid levels, promoting anti-atherosclerosis activities, and improving immune and coagulation functions. |
| chemical properties | yellow crystalline powder, soluble in methanol, derived from cattail yellow. |
| use | cattail glycoside has the effects of hemostasis, removing blood stasis and dredging rain. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: treatment of urination is unfavorable, breast carbuncle. |
Last Update：2024-04-09 21:01:54
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Product Name: Typhaneoside Visit Supplier Webpage Request for quotationCAS: 104472-68-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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