UNC0379

UNC0379 - Names and Identifiers

Name	6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine
Synonyms	UNC03 UNC0379 UNC 0379 UNC-0379 UNC0379, UNC-0379, UNC 0379 6,7-Dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-4-quinazolinamine 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine UNC0379
CAS	1620401-82-2

UNC0379 - Physico-chemical Properties

Molecular Formula	C23H35N5O2
Molar Mass	413.56
Density	1.168±0.06 g/cm3(Predicted)
Boling Point	606.3±65.0 °C(Predicted)
Solubility	Soluble in DMSO, not in water
Appearance	solid
Color	Tan
pKa	10.54±0.20(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Use	UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. UNC0379 is active in multiple biochemical assays. Its affinity to SETD8 was confirmed by ITC (isothermal titration calorimetry) and SPR (surface plasmon resonance) studies. Importantly, UNC0379 is selective for SETD8 over 15 other methyltransferases. The lysine methyltransferase SETD8 is the only known methyltransferase that catalyzes monomethylation of histone H4 lysine 20 (H4K20). Monomethylation of H4K20 has been implicated in regulating diverse biological processes including the DNA damage response.
In vitro study	UNC0379 is competitive with the peptide substrate and noncompetitive with the cofactor SAM.

UNC0379 - Preparation solution concentration reference

	1mg	5mg	10mg
1 mM	2.418 ml	12.09 ml	24.181 ml
5 mM	0.484 ml	2.418 ml	4.836 ml
10 mM	0.242 ml	1.209 ml	2.418 ml
5 mM	0.048 ml	0.242 ml	0.484 ml

Last Update：2024-01-02 23:10:35

UNC0379 - Introduction

6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine is a compound with the chemical name N-((2,5-dioxy -1,4-phenyl) ethyl) acrylamide.

6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine is mainly used in biochemical and pharmaceutical research, in particular, it plays an important role in the study of epigenetic regulation. It is a small molecule compound that selectively inhibits the enzyme COMMD1, which plays a regulatory role in the process of DNA methylation in cells. The 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine can be used to study the effects of DNA methylation and may aid in the development of new cancer therapeutics.

6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine is generally produced by an organic synthesis method. Specific preparation methods may vary by manufacturer and research laboratory.

Regarding the safety information of 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine, because it is a chemical substance, therefore, it is necessary to operate carefully in the laboratory and comply with safe operating procedures. It may have some potentially dangerous properties, such as irritation and toxicity. Therefore, when using 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine, it is necessary to wear appropriate protective equipment such as gloves, glasses and laboratory coats, avoid contact with skin, eyes and mouth. In addition, it should be used in a well-ventilated place, properly dispose of waste after use, and comply with relevant laws and regulations. For specific safe operation and storage information, reference should be made to the safety data sheets provided by the supplier. Before using the 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine, it is recommended to consult a professional for more detailed and accurate information.

Last Update：2024-04-09 21:54:55