UNC926
UNC-926 Hydrochloride
CAS: 1184136-10-4
Molecular Formula: C16H21BrN2O
UNC926 - Names and Identifiers
UNC926 - Physico-chemical Properties
| Molecular Formula | C16H21BrN2O |
| Molar Mass | 337.25 |
| Solubility | DMSO: soluble2mg/mL, clear (warmed) |
| Appearance | powder |
| Color | white to light brown |
| Storage Condition | 2-8°C |
| In vitro study | UNC926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3 ( IC 50 of 3.2 μM), with a decrease in affinity for the other MBT domains and no binding to CBX7. UNC926 (1-25 μM) inhibits binding of the 3xMBT domain to H4K20me1.UNC926 inhibits the association of L3MBTL13xMBT with the appropriate histonepeptides in a dose-dependent manner. UNC926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC926 for L3MBTL1 over 53BP1. |
UNC926 - Risk and Safety
| WGK Germany | 3 |
UNC926 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.676 ml | 13.379 ml | 26.758 ml |
| 5 mM | 0.535 ml | 2.676 ml | 5.352 ml |
| 10 mM | 0.268 ml | 1.338 ml | 2.676 ml |
| 5 mM | 0.054 ml | 0.268 ml | 0.535 ml |
Last Update：2024-01-02 23:10:35
UNC926 - Reference Information
| biological activity | UNC926 is a methyl-lysine (Kme) reader domain inhibitor, which can specifically inhibit L3MBTL1, and its IC50 is 3.9 μM. |
| target | TargetValue L3MBTL1 () 3.9 μM(Kd) |
| Target | Value |
| L3MBTL1 () | 3.9 μM(Kd) |
| in vitro study | UNC926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3 ( IC 50 of 3.2 μM), with a decrease in affinity for the other MBT domains and no binding to CBX7. UNC926 (1-25μM) inhibits binding of the 3xMBT domain to H4K20me1.UNC926 inhibits the association of L3MBTL13xMBT with the appropriate histonepeptides in a pose-dependent manner. UNC926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC926 for L3MBTL1 over 53BP1. |
| use | UNC-926 is a methyl-lysine reader antagonist; binds to the MBT domain of the L3MBTL1 protein (Kd = 3.9 μM). UNC-926 selectively inhibits the interaction between L3MBTL13XMBT-H4K20me1 in a peptide pull down say. |
Last Update：2024-04-09 21:11:58
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Product Name: UNC-926 Hydrochloride Visit Supplier Webpage Request for quotationCAS: 1184136-10-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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