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UNII-42NCM1BW43

Sulbutiamine

CAS: 3286-46-2

Molecular Formula: C32H46N8O6S2

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UNII-42NCM1BW43 - Names and Identifiers

Name Sulbutiamine
Synonyms Arcalion
arcalion
Vitaberin
BRN 0741531
Sulbutiamina
SULBUTIAMINE
Sulbutiamine
Bisibutiamin
Bisibutiamine
Sulbutiaminum
BISIBUTIAMINE
Bisibuthiamine
UNII-42NCM1BW43
O,O-Diisobutyrate
Sulbutiaminum [INN-Latin]
Sulbutiamina [INN-Spanish]
O-Isobutyroylthiamine disulfide
O,O'-Diisobutyrylthiamine disulfide
SULBUTIAMINE(ARCALION,BISIBUTIAMINE)
Thiamine disulfide O,O-diisobutyrate
5-25-12-00169 (Beilstein Handbook Reference)
Bis(1-(4-amino-2-methyl-5-pyrimidinyl)-2-formyl-3,9-dimethyl-8-oxo-2-aza-7-oxa-3-decen-4-yl)disulfid
Bis(1-(2-isobutyryloxyethyl)-2-(N-((4-amino-2-methyl-5-pyrimidinyl)methyl)formamido)-1-propenyl)disulfid
3,3'-Dithiobis[4-[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-formylamino]-3-penten-1-ol] bis(2-methylpropionate)
disulfanediylbis(2E)-2-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}pent-2-ene-3,5-diyl bis(2-methylpropanoate)
Propanoic acid, 2-methyl-, dithiobis(3-(1-(((4-amino-2-methyl-5-pyrimidinyl)methyl)formylamino)ethylidene)-3,1-propanediyl) ester
N,N'-(Dithiobis(2-(2-hydroxyethyl)-1-methylvinylene))bis(N-((4-amino-2-methyl-5-pyrimidinyl)methyl)formamide) diisobutyrate (ester)
Bis(2-methylpropionic acid)[dithiobis[3-[1-[[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino]ethylidene]-3,1-propanediyl]] ester
Formamide, N,N'-(dithiobis(2-(2-hydroxyethyl)-1-methylvinylene))bis(N-((4-amino-2-methyl-5-pyrimidinyl)methyl)-, diisobutyrate (ester)
CAS 3286-46-2
EINECS 221-937-3
InChI InChI=1/C32H46N8O6S2/c1-19(2)31(43)45-11-9-27(21(5)39(17-41)15-25-13-35-23(7)37-29(25)33)47-48-28(10-12-46-32(44)20(3)4)22(6)40(18-42)16-26-14-36-24(8)38-30(26)34/h13-14,17-20H,9-12,15-16H2,1-8H3,(H2,33,35,37)(H2,34,36,38)/b27-21+,28-22+

UNII-42NCM1BW43 - Physico-chemical Properties

Molecular FormulaC32H46N8O6S2
Molar Mass702.89
Density1.1323 (rough estimate)
Melting Point140.5-141.5 °C
Boling Point892.5±65.0 °C(Predicted)
Flash Point493.5°C
Solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Vapor Presure1.63E-32mmHg at 25°C
AppearanceSolid
ColorWhite to Off-White
Merck14,9297
pKa5.82±0.10(Predicted)
Storage Conditionunder inert gas (nitrogen or Argon) at 2-8°C
StabilityHygroscopic
Refractive Index1.7400 (estimate)
Physical and Chemical PropertiesThe molecular formula of sulbuthiamine is C32H46N8O6S2, which is a vitamin B1 derivative developed by the French company Servier. The special drug patent 5921M states that this product is a preparation with Vitamin B1 activity, which can increase the content of vitamin B1 in blood and can treat all vitamin B1 deficiency.
UseThis product is for scientific research only and shall not be used for other purposes.
In vitro study Sulbutiamine shows neuroprotective effects on hippocampal CA1 pyramidal neurons subjected to oxygen-glucose deprivation. Sulbutiamine enhances electrophysiological properties such as excitatory synaptic transmissions and intrinsic neuronal membrane input resistance in a concentration-dependent manner. Sulbutiamine attenuates apoptotic cell death induced by serum deprivation and stimulates GSH and GST activity in a dose dependent manner. Furthermore, sulbutiamine decreases the expression of cleaved caspase-3 and AIF.

UNII-42NCM1BW43 - Risk and Safety

RTECSLQ2721000

UNII-42NCM1BW43 - Reference Information

biological activity Sulbutiamine is a highly fat-soluble synthetic vitamin B1 analog, which can be used for the study of weakness.
category toxic substances
toxicity classification poisoning
acute toxicity abdominal cavity-rat LD50: 660 mg/kg; Intravenous-rat LD50: 110 mg/kg
flammability hazard characteristics flammability; thermal decomposition of toxic nitrogen oxides, sulfur oxide smoke
storage and transportation characteristics warehouse ventilation and low temperature drying
fire extinguishing agent dry powder, foam, sand, carbon dioxide, mist water
Last Update：2024-04-10 22:29:15
UNII-42NCM1BW43
Supplier List
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: O,O-Diisobutyrate;3,3'-Dithiobis[4-[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-formylamino]-3-penten-1-ol] bis(2-methylpropionate) Visit Supplier Webpage Request for quotation
CAS: 3286-46-2
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CAS: 3286-46-2
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Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: Sulbutiamine Visit Supplier Webpage Request for quotation
CAS: 3286-46-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: O,O-Diisobutyrate;3,3'-Dithiobis[4-[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-formylamino]-3-penten-1-ol] bis(2-methylpropionate) Visit Supplier Webpage Request for quotation
CAS: 3286-46-2
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Sulbutiamine Request for quotation
CAS: 3286-46-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: Sulbutiamine Visit Supplier Webpage Request for quotation
CAS: 3286-46-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
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UNII-42NCM1BW43
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