UNII-743LRP9S7N
Chloroprotoferrihem
CAS: 16009-13-5
Molecular Formula: C34H31ClFeN4O4-
UNII-743LRP9S7N - Names and Identifiers
UNII-743LRP9S7N - Physico-chemical Properties
| Molecular Formula | C34H31ClFeN4O4- |
| Molar Mass | 650.94 |
| Melting Point | 300 °C |
| Boling Point | °Cat760mmHg |
| Water Solubility | practically insoluble |
| Solubility | Easily soluble in dilute alkali solution, slightly soluble in alcohol, insoluble in dilute acid and water |
| Appearance | Black powder |
| Color | black |
| Exposure Limit | ACGIH: TWA 1 mg/m3NIOSH: TWA 1 mg/m3 |
| Merck | 14,4644 |
| BRN | 5229914 |
| Storage Condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. Combustible. |
| Sensitive | Sensitive to light |
| MDL | MFCD00010726 |
| Physical and Chemical Properties | Heme is a red blood element in the blood and muscle of higher animals. It exists in red blood cells and binds to proteins to form complex proteins, namely hemoglobin (Hb) or myoglobin (Mb). Hb is a carrier that transports O2 and a portion of CO2, and is a buffering substance that maintains a constant pH of the blood. Under certain conditions, the heme can be separated from the protein. Heme is formed by complexation of protoporphyrin IX with iron (II). Heme crystals are blue-black, insoluble in water, soluble in acidic acetone, alkaline aqueous solution, easy to form polymer in solution. There is a resonance structure in its molecule and its properties are stable. Hemin (Hemin) is black green amorphous or long needle-like crystals, insoluble in water, soluble in acidic acetone and alkaline water. The molecular formula C34H32ClFe (III) N4O4 has a molecular weight of 651.96. Mainly used for anti-anemia, anticancer drug raw materials. 1930h. Fischer (Germany) received the Nobel Prize in Chemistry for the synthesis of heme. The heme is nitrated, and the iron ion is released, and the appropriate amount of 1, 10-phenanthroline is quantitatively formed in the buffer solution of pH 4.6 to form the orange-red complex by spectrophotometry in (510±1). Determination of iron ion content in heme at nm. The results showed that the orange-red complex formed by iron ion and 1, 10-phenanthroline had the maximum absorption at the wavelength of (510±1)nm and was in the range of 0.4-2.8 μg/ml, the correlation coefficient r = 0.9999. The average recovery X = 98.87%,RSD = 0.58%. |
UNII-743LRP9S7N - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S22 - Do not breathe dust. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | LJ8080000 |
| FLUKA BRAND F CODES | 8 |
| TSCA | Yes |
| HS Code | 29349990 |
UNII-743LRP9S7N - Reference
| Reference Show more | 1. Zuli Karjiang · Ahemati Lin Jing Yu Qian Zhao Jin. Effects of Ili black bee propolis on lactate dehydrogenase and related genes of Streptococcus mutans in different states [J]. Chinese Journal of Microecology 2015 27(05):543-547. 2. Yu Qian, Xue Rui, Zhao Jin, Lin Jing. Experimental study on the growth of major oral cariogenic bacteria and biofilm by Ili black bee propolis [J]. Chinese Journal of Microecology 2015 27(12):1403-1406 1410. 3. From Zhaoxia, Yuan Xiyu, Wu Zeyu, et al. Experimental study on the effect of Sophora flavescens extract on major cariogenic bacteria in oral cavity [J]. Chinese Journal of Microecology, 2019, v.31(10):76-82. 4. Guo Qingying, Liu Min, Zhao Yanna, spectroscopy and Cytotoxicity of Epigallocatechin Gallate on the Interaction between Daunorubicin and Human Serum Albumin [J]. Spectroscopy and Spectral Analysis, 2020, 040(006):1821-1827. 5. Lin Qian, Li Chunmei. Effect of Persimmon Tannin on Intestinal Microbes in Simulated Fermentation Environment in Vitro [J]. Food Industry Science and Technology, 2015, 36(022):160-163,167. 6. Cheng Ruochen, Zhang Ying, He Tengfei, Guo Rui. Clinical significance of protoporphyrin IX in HBV-related cirrhosis [J]. Medical Information, 2021,34(06):73-77. 7. Yao Lunhuan, Hao Gang, Tang Shanhu, Li Sining. Optimization of conditions for color removal of porcine hemoglobin by trypsin [J]. Meat Research, 2020,34(10):19-25. 8. Cheng Yuxin. Regulation of blueberry pomace fermented by Lactobacillus casei on intestinal barrier function in mice with high fat diet and its mechanism [D]. Huazhong Agricultural University, 2020. 9. Jin, Y. I., et al. "Disposition of astragaloside IV via enterohepatic circulation is affected by the activity of the intestinal microbiome." Journal of agricultural and food chemistry 63.26 (2015): 6084-6093. 10. [IF = 10.618] Wenjing Wang et al. "Highly electrocatalytic biosensor based on Hemin @ AuNPs/reduced graphene oxide/chitosan nanohybrids for non-enzymatic ultrasensitive detection of hydrogen peroxide in living cells." Biosens Bioelectron. 2019 May;132:217 11. [IF = 5.316] Songmei Li et al. "Enhanced electronic interaction in hemin @ Ni(OH)2 composite for efficient electrocatalytic oxygen evolution." J Alloy Compd. 2022 Feb;892:161780 12. [IF = 5.279] Fuqiong Zhou et al. "Elaboration of the Comprehensive Metabolic Profile of Salvianolic Acid A in Vivo and in Vitro Using UFLC-Q/TOF-MS." J Agr Food Chem. 2019;67(44):12199-12207 |
UNII-743LRP9S7N - Introduction
It appears brown under transmitted light and steel blue under reflected light. Soluble in dilute ammonia water, soluble in sodium hydroxide solution to produce heme, soluble in strong organic bases (such as trimethylamine and dimethylaniline) and acetic acid, soluble in concentrated sulfuric acid and lose iron, slightly soluble in 70% ~ 80% ethanol, almost insoluble in carbonate solution, dilute acid and water, stable in water. Caking at 240 ℃ and not melting at 300 ℃. Blood test stain.
Last Update：2022-10-16 17:14:13
UNII-743LRP9S7N - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Overview | Hemin is a metal porphyrin compound with a simpler structure. It is formed by the complexation of a molecule of ferrous iron and protoporphyrin. It is a natural heme (heme) in vitro group substitution, and its chemical properties are similar to heme. Heme, as an indispensable small molecule in organisms, widely exists in various animals, plants, microorganisms, algae and other organisms. Wien Bio extracts hemin from livestock and poultry blood through its own patented technology. Through research and practice, it is found that hemin has a significant effect on alleviating abiotic stress in plants. |
| Application | Heme chloride (also known as porphyrin, hematoporphyrin, heme chloride, heme) is extracted from pig and bovine blood and is recognized by modern medicine as a biological iron source for preventing and treating iron deficiency anemia, with high absorption rate and good effect. It has no iron smell and does not stimulate the gastrointestinal tract. It is the first choice for the production of iron supplement food, medicine, health care products and cosmetics. |
| efficacy and action | Hemin is both a synthetic substrate for HO-1 and an accelerator for HO-1, which can induce the activity of HO-1, improve the ability of plants to resist oxidative stress and regulate plant metabolism. Studies have found that hemin, as an inducer of HO-1, can significantly induce the expression of HO-1 by exogenous addition, and alleviate the growth inhibition and oxidative stress caused by heavy metal stress by regulating the antioxidant system of crop roots. At the same time, hemin can alleviate osmotic stress caused by salt stress. In addition, hemin can also promote the accumulation of fresh weight of plants and the growth of taproots. |
| use | in the food industry, heme can replace nitrite and synthetic pigment in meat products; in the pharmaceutical industry, heme can be used as a semi-synthetic bilirubin raw material, and can be used to prepare anti-cancer drugs; clinically, heme can be made into heme iron tonic. The nutritional supplement (iron fortifier) is extracted from pig blood. It is recognized by modern medicine to prevent and treat iron deficiency anemia, with high absorption rate and good effect. The biological iron source has no iron smell and does not irritate the intestines and stomach. It is the first choice for the production of natural iron supplement food, medicine, health care products and cosmetics. Biochemical research; used as a blood test stain; used for the preparation of hematoporphyrin hydrochloride |
| production methods | heme preparation methods include base-organic solvent method, glacial acetic acid method, acetone method, methanol or methanol-ethanol method, ion exchange cellulose method. Methods 60L of methanol and 1kg of diethylamine were added into the reaction tank by 1. base-organic solvent method, stirred evenly, 5kg of fresh bovine blood powder was added, stirred and extracted at 45 ℃ for 1h, cooled and filtered, filtrate was concentrated to 5L, glacial acetic acid 10L and strontium chloride 200g were added, residual methanol was removed by heating and distilled, heated to 100-102 ℃ for 1h, cooled and filtered, and hemin crystals were collected. The hemin crystals were washed with glacial acetic acid, water, and acetone in turn, and dried to prepare 85g of hemin. Bovine blood powder [methanol, diethylamine] →[45 ℃, 1h][filtration] → filtrate [ice Hac, SrCl2]→[100-102 ℃, 1h][filtration, washing, drying] → heme 60L methanol and 5kg spray-dried bovine red blood cells are added to the reaction tank, stirred evenly, extracted at 40 ℃ for 30min, cooled, filtered, filtrate concentrated to 5L, and glacial acetic acid 10L is added, 100g of sodium chloride, add 2L of water to dissolve, heat distillation to remove residual methanol, heat to 100 ℃ for 1h, cool, filter, and collect hemin crystals. The hemin crystals were washed with glacial acetic acid and water, dried, and 65g of hemin was prepared. Bovine red blood cells [methanol] →[40 ℃, 30min][filtration] → filtrate [ice Hac, NaCl, H2O]→[100 ℃, 1h][filtration, washing, drying] → preparation of heme chlorinated heme 300kg of fresh blood powder, 1200L of methanol, 30kg of dichloroacetic acid, stirring evenly, stirring with 45 ℃ for 1h, cooling, filtering, filtrate concentrated to dry to obtain 45kg of heme. Fresh blood meal [methanol, dichloroacetic acid] →[45 ℃, 1h][filtration, concentration] → preparation of heme hemin 45kg is taken, 100L of glacial acetic acid containing 2kg NaCl is added, boiled and refluxed for 1h, cooled and filtered to obtain hemin, washed with glacial acetic acid and water in turn, dried to obtain hemin 4.8kg. Heme [mixed solvent of NaCl and glacial acetic acid] → [boiling for 1h][washing, drying] → preparation of extracting acidic blood powder 2. methanol-ethanol mixed solvent by hemin chloride method take 100kg of blood powder, add 0.6mol/L HCl solution 100kg, stir hemolysis, spray drying to obtain 40kg of acidic blood powder. Blood Powder [HCl]→ Preparation of Acid Blood Powder Heme 40kg of acid blood powder was extracted three times with a mixed solvent composed of 90% ethanol, 6% methanol and 4% water. The dosage of the mixed solvent was 800L, 300L and 200L respectively. The supernatant was combined and distilled and concentrated to obtain heme. Acid blood powder [mixed solvent] → [extract 3 times] supernatant [concentrate] → heme. |
Last Update：2024-04-09 21:11:58
Supplier List
Product Name: Chloroprotoferrihem Request for quotation
CAS: 16009-13-5
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 16009-13-5
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: Hematin chloride Visit Supplier Webpage Request for quotationCAS: 16009-13-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: Chloroprotoferrihem Request for quotation
CAS: 16009-13-5
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 16009-13-5
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: Hematin chloride Visit Supplier Webpage Request for quotationCAS: 16009-13-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History