Name | UTP |
Synonyms | UTP UTP-NA UTP, 3NA UTP, NA3H UTP SODIUM SALT UTP TRISODIUM SALT URIDINE 5'-TRIPHOSPHATE 5'-URIDYLATE TRIPHOSPHATE URIDINE-5'-TRIPHOSPHATE NA3-SALT |
CAS | 63-39-8 |
EINECS | 200-558-7 |
Molecular Formula | C9H15N2O15P3 |
Molar Mass | 484.14 |
Density | 2.106±0.06 g/cm3(Predicted) |
Flash Point | 113 °C |
Appearance | Form liquid, color colorless |
pKa | pK1:7.58 (25°C) |
Storage Condition | Sealed in dry,2-8°C |
Physical and Chemical Properties | EPA Chemical Information Uridine 5 '-(tetrahydrogen triphosphate) (63-39-8) |
Hazard Symbols | Xn - Harmful |
Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R68/20/21/22 - |
Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 1 |
Reference Show more | 1. Tiantian Man, Wei Lai, Mingshu Xiao, Xiwei Wang, Arun Richard Chandrasekaran, Hao Pei, Li Li,A versatile biomolecular detection platform based on photo-induced enhanced Raman spectroscopy,Biosensors and Bioelectronics,Volume 147,2020,111742,ISSN 0956 2. [IF=10.618] Tiantian Man et al."A versatile biomolecular detection platform based on photo-induced enhanced Raman spectroscopy."Biosens Bioelectron. 2020 Jan;147:111742 |
1mg | 5mg | 10mg | |
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1 mM | 2.066 ml | 10.328 ml | 20.655 ml |
5 mM | 0.413 ml | 2.066 ml | 4.131 ml |
10 mM | 0.207 ml | 1.033 ml | 2.066 ml |
5 mM | 0.041 ml | 0.207 ml | 0.413 ml |
biological activity | Uridine triphosphate (UTP;Uridine 5 '-triphosphate) is a nucleotide that regulates the functions of pancreatic endocrine and exocrine, proliferation, channels, transporters and intracellular signaling in normal and disease states. | |
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in vitro study |
Uridine triphosphate treatment induces Schwannoma cell migration through activation of P2Y2 receptors and through the increase of extracellular matrix metalloproteinase-2 (MMP-2) activation and expression. Uridine triphosphate-induced proliferation is mediated by protein kinase D, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, phosphatidylinositol 3-kinase (PI3K), Akt, and phospholipase D. Uridine triphosphate increases phosphorylation of Akt through protein kinase C, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, and PI3K.
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in vivo study |
Uridine triphosphate reduces mitochondrial calcium levels following hypoxia. Early or late uridine triphosphate preconditioning is effective to reduce infarct size and superior myocardial function. Uridine triphosphate treatment increases the number of monocytes and macrophages infiltrating the pouch and up-regulates the gene expression of IL-4 and IL-13 in the regional lymph nodes. |