Unii-4m1609828o

Name	Balaglitazone
Synonyms	Nn2344 Drf-2593 Drf 2593 Balaglitazone Unii-4m1609828o Balaglitazone [inn] 2,4-Thiazolidinedione,5-[[4-[(3,4-dihydro-3-methyl-4-oxo-2-quinazolinyl) methoxy]phenyl]methyl]-
CAS	199113-98-9

Molecular Formula	C20H17N3O4S
Molar Mass	395.43
Density	1.45±0.1 g/cm3(Predicted)
pKa	6.33±0.50(Predicted)
Storage Condition	Inert atmosphere,Store in freezer, under -20°C
In vitro study	Balaglitazone is a selective partial PPARγ agonist with an EC 50 of 1.351 μM. Balaglitazone (5-100 μM) has equal cytotoxicity towards K562 and K562/DOX cells. Balaglitazone decreases doxorubicin cytotoxicity in K562 and K562/DOX cells, with IC 50 s of 0.117 μM and 0.53 μM, respectively. Balaglitazone reverses multidrug resistance (MDR) in K562/DOX cells. Balaglitazone (25 µM) increases Rh123 accumulation in K562/DOX cells, but does not increases MFI in K562 cells. Balaglitazone downregulates P-gp expression in K562/DOX cells, and such effects are via upregulation of PTEN in K562/DOX cells, and be abolished by PTEN inhibition.
In vivo study	Balaglitazone (3 mg/kg, p.o.) shows antihyperglycaemic activity in fully diabetic and insulin resistant db/db mice, and is more potent than the full PPARγ agonist rosiglitazone. Balaglitazone (10 mg/kg, p.o.) suppresses overall glucose, decreases insulin levels, and increases bodyweight in male diet-induced obese rats, and such effects are equal to that of 30 mg/kg pioglitazone.

Product Name: Balaglitazone Visit Supplier Webpage Request for quotation
CAS: 199113-98-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Product Name: Balaglitazone Visit Supplier Webpage Request for quotation
CAS: 199113-98-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

View History

Unii-4m1609828o

Unii-4m1609828o Request for Quotation