VE821
VE-821
CAS: 1232410-49-9
Molecular Formula: C18H16N4O3S
VE821 - Names and Identifiers
VE821 - Physico-chemical Properties
| Molecular Formula | C18H16N4O3S |
| Molar Mass | 368.41 |
| Density | 1.394 |
| Melting Point | 247-249°C |
| Boling Point | 568.4±50.0 °C(Predicted) |
| Solubility | Soluble in DMSO (40 mg/ml) |
| Appearance | powder |
| Color | white to beige |
| pKa | 9.97±0.70(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| In vitro study | VE-821 acts on ATR with excellent selectivity, and acts on related PIKKs ATM, DNA-PK, mTOR and PI3K with the lowest cross-reactivity, Ki is 16 μm, 2.2 μm, >1 M and 3.9 M. VE-821 alone, it kills most of the cancer cell population, but acts on normal cells to reversibly restrict cell cycle progression, producing minimal death or long-term deleterious effects. The combination of VE-821 and Cisplatin had the most significant synergistic effect. VE-821 inhibit H2AX cell growth with an IC50 of 800 nM. |
VE821 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.714 ml | 13.572 ml | 27.144 ml |
| 5 mM | 0.543 ml | 2.714 ml | 5.429 ml |
| 10 mM | 0.271 ml | 1.357 ml | 2.714 ml |
| 5 mM | 0.054 ml | 0.271 ml | 0.543 ml |
Last Update：2024-01-02 23:10:35
VE821 - Reference Information
| biological activity | VE-821 is a potent, selective, ATP-competitive inhibitor of ATR, A Ki/IC50 of 13 nM/26 nM inhibits H2AX phosphorylation with minimal inhibitory activity on PIKKs ATM, DNA-PK, mTOR and PI3Kγ. |
Last Update：2024-04-09 02:00:14
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Product Name: VE-821 Visit Supplier Webpage Request for quotationCAS: 1232410-49-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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Spot supply
Product Name: VE-821 Visit Supplier Webpage Request for quotationCAS: 1232410-49-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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