VQIGDTLRBSNOBV-DYXOGNCHSA-N

Name	PF-03394197 Oclacitinib maleate
Synonyms	PF-03394197 Oclacitinib Oclacitinib maleate PF-03394197 maleate VQIGDTLRBSNOBV-DYXOGNCHSA-N
CAS	1640292-55-2

Molecular Formula	C19H27N5O6S
Molar Mass	453.51258
Storage Condition	-20℃
In vitro study	PF-03394197 inhibits JAK family members with an IC50 of 10-99 nM and has little inhibitory effect on other non-JAK kinases. PF-03394197 is a very potent inhibitor of JAK1 and also inhibits the function of JAK1-dependent cytokines in several anti-allergic, inflammatory and pruritic responses. It has little effect on cytokines that are not involved in activating JAK1.
In vivo study	Treatment by oral route at a PF-03394197 of 0.4-0.6 mg/kg twice a day is safe and effective for the treatment of pruritus due to allergic dermatitis. During the treatment period, the application of PF-03394197 alleviated itching within 24 hours, and in the experiment, more than 70% of the experimental animals (dogs) reduced the itching response by more than 50% on Day 7.

Last Update：2024-01-02 23:10:35

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Product Name: Oclacitinib Maleate Visit Supplier Webpage Request for quotation
CAS: 1640292-55-2
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Product Name: PF-03394197;Oclacitinib maleate Visit Supplier Webpage Request for quotation
CAS: 1640292-55-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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