WIN-552122
WIN 55,212-2 MESYLATE
CAS: 131543-23-2
Molecular Formula: C28H30N2O6S
WIN-552122 - Names and Identifiers
WIN-552122 - Physico-chemical Properties
| Molecular Formula | C28H30N2O6S |
| Molar Mass | 522.61 |
| Boling Point | 627.7°C at 760 mmHg |
| Flash Point | 333.4°C |
| Solubility | 0.1 M HCl: 0.25mg/mL |
| Vapor Presure | 1.14E-15mmHg at 25°C |
| Appearance | solid |
| Color | white to off-white |
| Storage Condition | Store at +4°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| Physical and Chemical Properties | Solubility: 0.1 M HCl: 0.25 mg/mL WGK Germany:3 |
| In vitro study | WIN 55,212-2 is more potent in CHO-CB2 cells than in CHO-CB1 cells by a factor of 6O. WIN 55,212-2 has no effect on arachidonic acid release in CHO-CB2 or control CHO cells. WIN 55,212-2 fails to stimulate any increase in intracellular Ca 2+ up to 10 μM. In primary cultures of rat cerebral cortex neurons, WIN 55,212-2 (0.01--100 nM) increases extracellular glutamate levels, displaying a bell-shaped concentration-response curve. The facilitatory effect of WIN 55,212-2 (1 nM) is fully counteracted by SR141716A (10 nM), by the replacement of the normal Krebs Ringer-bicarbonate buffer with a low Ca 2+ medium (0.2 mM) and by the IP(3) receptor antagonist xestospongin C (1 μM). WIN 55,212-2 evokes CGRP release from TG neurons in vitro (EC 50 =26 μM) in a concentration- and calcium-dependent manner. WIN 55,212-2-2 neither inhibits capsaicin-evokes CGRP release nor does it inhibit forskolin-, isoproteranol- or prostaglandin E2-stimulated cAMP accumulation. WIN 55,212-2 significantly inhibits (EC 50 =1.7 μM) 50 mm K + -evoked CGRP release by approximately 70%. WIN 55,212-2 inhibition of 50 mm K + -evoked CGRP release is not reversed by antagonists of cannabinoid type 1 (CB1) receptor, but is mimicks in magnitude and potency (EC 50 =2.7 μM) by its cannabinoid-inactive enantiomer WIN 55,212-2-3. |
| In vivo study | In the prefrontal cortex WIN 55,212-2 (0.1 and 1 mg/kg i.p.) increases dialysate glutamate levels from of the awake rat, while the lower (0.01 mg/kg) and the higher (2 mg/kg) doses are ineffective. Furthermore, the WIN 55,212-2 (0.1 mg/kg)- induced increase of dialysate glutamate levels is counteracted by pretreatment with the selective CB(1) receptor antagonist SR141716A (0.1 mg/kg, i.p.) and by the local perfusion with a low-calcium Ringer solution (Ca 2+ 0.2 mM). WIN 55,212-2 (0.5, 1, 3, 5, 10 and 15 mg/kg, i.p.) does not alter the seizure threshold at low doses, while higher doses of the drug significantly increases the threshold in a dose-dependent manner. The anticonvulsant effect of WIN 55,212-2, which is observed with doses as high as 5 mg/kg, can be observed with doses as low as 0.5 mg/kg in groups pre-treated with 20 mg/kg of pioglitazone. |
WIN-552122 - Risk and Safety
| WGK Germany | 3 |
WIN-552122 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.913 ml | 9.567 ml | 19.135 ml |
| 5 mM | 0.383 ml | 1.913 ml | 3.827 ml |
| 10 mM | 0.191 ml | 0.957 ml | 1.913 ml |
| 5 mM | 0.038 ml | 0.191 ml | 0.383 ml |
Last Update：2024-01-02 23:10:35
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Spot supply
Product Name: Win 55,212-2 Mesylate Visit Supplier Webpage Request for quotationCAS: 131543-23-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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