Wilfortrin - Names and Identifiers
Name | Wilfortrine
|
Synonyms | Wilfortrin Wilfortrine 8α-Acetoxy-2-O-deacetyl-8-deoxo-2-O-(3-furanylcarbonyl)-26-hydroxyevonimine 3-Furancarboxylic acid, (8R,9R,10R,11S,12R,13R,14R,15S,18R,21S,22S,23R)-10,13,22,23-tetrakis(acetyloxy)-12-[(acetyloxy)methyl]-7,8,9,10,12,13,14,15,17,18,19,20-dodecahydro-18,21-dihydroxy-8,18,21-trimethyl-5,17-dioxo-8,11-epoxy-9,12-ethano-11,15-methano-5H,11H-[1,9]dioxacyclooctadecino[4,3-b]pyridin... 3-Furancarboxylic acid,(8R,9R,10R,11S,12R,13R,14R,15S,21S,22S,23R)-10,13,22,23-tetrakis(acetyloxy)-12-[(acetyloxy)methyl]-7,8,9,10,12,13,14,15,17,18,19,20-dodecahydro-18,21-dihydroxy-8,18,21-trimethyl-5,17-dioxo-8,11-epoxy-9,12-ethano-11,15-methano-5H,11H-[1,9]dioxacyclooctadecino[4,3-b]pyridin-14-ylester
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CAS | 37239-48-8
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Wilfortrin - Physico-chemical Properties
Molecular Formula | C41H47NO20
|
Molar Mass | 873.81 |
Density | 1.46±0.1 g/cm3(Predicted) |
Melting Point | 237.5-238.0℃ |
Boling Point | 884.4±65.0 °C(Predicted) |
Specific Rotation(α) | (Me2CO)+10 |
Solubility | Chloroform, dichloromethane, ethyl acetate, DMSO, acetone, etc. Insoluble in water. |
Appearance | Powder |
pKa | 11.52±0.70(Predicted) |
Storage Condition | 2-8℃ |
Wilfortrin - Introduction
Wilfortrine, also known as William's base (Wilfortrine), is a natural product, belonging to the quinoline alkaloid family. Its chemical formula is C22H26N2O4 and has a structure similar to quinoline.
Wilfortrine is a white crystalline powder with a faint bitter taste. It has analgesic, antispasmodic, anti-inflammatory, antihypertensive and increase vascular elasticity and other pharmacological effects. Therefore, in traditional Chinese medicine is often used to treat rheumatoid arthritis, gout, chronic arthritis and neuropathy.
The preparation method of Wilfortrine is generally extracted from Tripterygium wilfordii (Tripterygium wilfordii) plants. Extraction methods generally include supercritical fluid extraction, solvent extraction, and the like.
However, Wilfortrine should be used with caution because of its toxicity. It can cause damage to the liver, and may lead to liver toxicity, such as abnormal liver function, jaundice and so on. Therefore, when using Wilfortrine should be used under the guidance of a doctor, with regular monitoring of liver function. At the same time, people with liver disease, pregnant women, lactating women, and children should avoid use.
Last Update:2024-04-10 22:29:15