Wismut-aluminat
Bismuth Aluminate
CAS: 12284-76-3
Molecular Formula: Al3BiO6
Wismut-aluminat - Names and Identifiers
Wismut-aluminat - Physico-chemical Properties
| Molecular Formula | Al3BiO6 |
| Molar Mass | 385.921394 |
| Use | Mainly used as antacids, with neutralizing gastric acid and astringent effect |
Wismut-aluminat - Upstream Downstream Industry
Wismut-aluminat - Nature
Open Data Verified Data
white or off-white powder, odorless and tasteless. Insoluble in water or ethanol
Last Update：2024-01-02 23:10:35
Wismut-aluminat - Preparation Method
Open Data Verified Data
prepared from the reaction of sodium aluminate with bismuth nitrate.
Last Update：2022-01-01 09:04:50
Wismut-aluminat - Use
Open Data Verified Data
anti-acid and anti-ulcer drugs. It is mainly applied to gastric and duodenal ulcer, Chronic superficial gastritis, hyperacidity and nervous dyspepsia.
Last Update：2022-01-01 09:04:50
Wismut-aluminat - Compound bismuth aluminate tablets
Authoritative Data Verified Data
each tablet of this product contains bismuth aluminate calculated as bismuth (Bi), which should be 79~97mg; Calculated as aluminum (A1), which should be 30.6~37.4mg. The content of heavy magnesium carbonate shall be 149 ~ 183mg calculated as magnesium oxide (MgO); The content of licorice extract powder shall be calculated as glycyrrhizic acid (C42H62016) and shall not be less than 19.5mg.
prescription
bismuth aluminate 200g
Heavy magnesium carbonate 400g
Sodium bicarbonate 200g
Licorice extract powder 300g
Fran and rhamnoides 25g
Anise powder lOg
Appropriate amount of excipients
Made into 1000 tablets
trait
This product is a light yellow to tan tablet.
identification
- take about lg of the fine powder of this product, place it in the crucible, burn it until charring, cool it, add 3ml of nitric acid, heat it at low temperature until the nitric acid gas is removed, burn it to ash it completely, the residue was tested as follows.
- a small amount of residue was taken, and 5ml of dilute nitric acid was added to dissolve and filtered. Potassium iodide test solution was added dropwise to the filtrate to form a brown-red precipitate, and then excess potassium iodide test solution was added dropwise to dissolve the precipitate.
- take a small amount of residue, add 5ml of dilute hydrochloric acid, dissolve the residue, filter, add ammonia test solution Dropwise to the filtrate to form white precipitate, add several drops of sodium alizarin sulfonate indicator solution, the precipitate was noted as an orange-red color.
- take a small amount of residue, add 3ml of dilute hydrochloric acid to dissolve, adjust to Neutral with ammonia test solution, add 3ml of ammonia-ammonium chloride buffer solution (pH 10.0), filter, take several drops of filtrate on white porcelain plate, A few drops of sodium hydroxide solution and 1-2 drops of 5% p-nitrobenzeneazobenzene isophthalic acid solution were added, and blue precipitation occurred.
- take about 0.5g of the fine powder of this product, add 5ml of water and 3ml of dilute sulfuric acid, that is, bubble boiling, carbon dioxide gas; This gas is human calcium hydroxide test solution, white turbidity occurs.
- take about 0.5g of fine powder of this product, Add 10ml of dilute sulfuric acid, boil for 2 minutes, heat-filter, add 5ml of ether, shake extraction, extract ether layer, add 2ml of sodium hydroxide solution, shaking, orange-red in water layer.
- take about lg of the fine powder of this product, add 15ml of methanol, extract for 30 minutes at a slight temperature, filter, and check the filtrate under a UV lamp (254nm) to show yellow-green fluorescence.
- take about lg of the fine powder of this product, add 10ml of diethyl ether, shake for 10 minutes, filter on the porcelain evaporation dish, after the diethyl ether is evaporated and dried, 2 drops of the freshly prepared 5% vanillin sulfuric acid solution were added dropwise, and red-purple color was observed.
- a small amount of residual water was taken and dissolved by adding 3ml of dilute hydrochloric acid. Identification reaction of sodium salt was performed (General rule 0301).
- in the chromatogram recorded under the determination of glycyrrhizic acid content, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the control solution.
examination
In addition to the disintegration time, the relevant provisions under tablets (General rule 0101) should be met.
Content determination
- Take 20 pieces of bismuth, weigh accurately, grind finely, weigh appropriately (about 0.3g equivalent to bismuth aluminate), place in 50ml crucible, slowly burn until complete carbonization, cool, add 3ml nitric acid, heat at low temperature until the nitric acid gas is removed, and then burn to make it ash completely; Cool, add 20ml nitric acid solution (3-10), and transfer the residue to a 500ml Erlenmeyer flask, the funnel at the mouth of the bottle was set to reflux with micro-heat until the residue was dissolved (the solution was slightly turbid). After cooling, 200ml of water was added, 5 drops of Xylenol Orange indicator solution were added, and the solution was titrated with ethylenediamine tetraacetic acid disodium (0.05mol/L). Titration to the solution from orange to lemon yellow. Per 1 ml of disodium ethylenediaminetetraacetate titration solution (0.05mol/L) corresponds to 10.45mg of bismuth (Bi).
- aluminum the solution after bismuth determination was taken, ammonia test solution was added dropwise to precipitate the precipitate, and dilute nitric acid was added dropwise to dissolve the precipitate (pH is about 6), add 15ml of acetic acid-ammonium acetate buffer solution (pH 6.0), add 50ml of ethylenediamine tetraacetic acid disodium titration solution (0.05mol/L), boil for 10 minutes, cool, add 5 drops of Xylenol Orange indicator solution, titrated with zinc titration solution (0.05mol/L), the solution changed from lemon yellow to orange, and the titration results were corrected by blank test. Each 1 ml of ethylene diamine tetraacetic acid disodium titration solution (0.05mol/L equivalent to 1.349mg of aluminum (A1).
- magnesium oxide precise weighing an appropriate amount of the above fine powder (equivalent to 0.4g of heavy magnesium carbonate), placing it in a 50ml crucible, slowly burning until complete carbonization, cooling, adding 3ml of nitric acid, after heating at low temperature until the nitric acid gas was removed, the residue was completely Ash, cooled, transferred to a 50ml beaker with 15ml of dilute hydrochloric acid, boiled to dissolve the residue, and then added 20ml of water, add 1 drop of Methyl red indicator solution, add ammonia test solution Dropwise to make the red color of the solution disappear, then boil for 5 minutes, and filter while hot; Wash the filter residue with slightly warm 2% ammonium chloride solution 30ml, combine the filtrate and washing solution in a 100ml measuring flask, cool, add water to the scale, shake well, accurately take 20ml in The Erlenmeyer Flask, add water 20ml, add ammonia-ammonium chloride buffer (pH10.0) and triethanolamine solution (1-2) each 5ml, plus a small amount of Chrome Black T indicator, with ethylenediamine tetraacetic acid disodium titration solution (0.05mol/L) titration, to the solution of pure blue. Each 1 ml of ethylene diamine tetraacetic acid disodium titration solution (0.05mol/L equivalent to 2.015mg of MgO.
- glycyrrhizic acid was measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica as filler; Methanol -0.2mol/L ammonium acetate solution glacial acetic acid (67:33:1) as mobile phase; the detection wavelength was 250Nm. The number of theoretical plates shall not be less than 2000 according to the peak of ammonium glycyrrhizinate.
- precise weighing appropriate amount of the above fine powder (about 0.1g of the licorice extract), placing it in a 50ml measuring flask, adding 40ml of mobile phase, sonicating for 30 minutes, allowing to cool, and diluting to the scale with mobile phase, shake well, filter, take the continued filtrate as the test solution, take a precise amount of 10ul into the human liquid chromatograph, record the chromatogram; Take about 10mg of ammonium glycyrrhizinate reference substance, and determine with the same method. According to the external standard method to calculate the peak area, and the result is multiplied by 0.9797, that is.
category
antacids.
storage
sealed and stored in a dry place.
Last Update：2022-01-01 13:43:40
Wismut-aluminat - Compound bismuth aluminate capsules
Authoritative Data Verified Data
each grain of this product contains bismuth aluminate calculated by bismuth (Bi), should be 26.4~32.2mg; Calculated by aluminum (A1), should be 10.2~12.5mg; the content of heavy magnesium carbonate shall be 49.7 ~ 60.9mg calculated as magnesium oxide (MgO); The content of licorice extract powder shall be calculated as glycyrrhizic acid (C42H62016), and shall not be less than 6.0mg.
prescription
bismuth aluminate 66.7G
Heavy magnesium carbonate 133.3g
Sodium bicarbonate 66.7G
Licorice extract powder 100g
Fren and Rhamnus Thunb. 8.3g
Fennel powder 3.3g
Appropriate amount of excipients
Made into 1000 tablets
trait
The content of this product is light brown powder.
identification
- take about lg of the content of this product, place it in the crucible, burn until charring, cool, add 3ml nitric acid, heat at low temperature until nitric acid gas is removed, burn to Ash completely, the residue was tested as follows.
- a small amount of residue was taken, and 5ml of dilute nitric acid was added to dissolve and filtered. Potassium iodide test solution was added dropwise to the filtrate to form a brown-red precipitate, and then excess potassium iodide test solution was added dropwise to dissolve the precipitate.
- a small amount of residue was taken, and 5ml of dilute hydrochloric acid was added to dissolve and filter. Ammonia test solution was added dropwise to the filtrate until a white precipitate was formed.
- take a small amount of residue, add 3ml of dilute hydrochloric acid to dissolve, adjust to Neutral with ammonia test solution, add 3ml of ammonia-ammonium chloride buffer solution (pH 10.0), filter, take several drops of filtrate on white porcelain plate, A few drops of sodium hydroxide solution and 1 to 2 drops of 5% p-nitrophenyl azo-resorcinol solution were added, and blue precipitation occurred.
- take about 0.5g of the content of this product, add 5ml of water and 3ml of dilute sulfuric acid, that is, bubble boiling, carbon dioxide gas; This gas is passed into the calcium hydroxide solution, white turbidity occurs.
- take the content of this product about 0.5g, add dilute sulfuric acid 10ml, boil for 2 minutes, while the heat filtration, let cool, add ether 5ml, shake extraction, separate the ether layer, 2ml sodium hydroxide solution was added and the water layer was red-orange after shaking.
- take about lg of the content of this product, add methanol 15ml, extract for 30 minutes at a slight temperature, filter, and check the filtrate under a UV lamp (254nm) to show yellow-green fluorescence.
- take about lg of the content of this product, add 10ml of ether, shake for 10 minutes, filter, put the filtrate into a porcelain evaporation dish, and wait for the ether to volatilize and dry, 2 drops of freshly prepared 5% vanillin sulfuric acid solution were added dropwise, red-purple.
- a small amount of the residue was taken, and 3ml of dilute hydrochloric acid was added to dissolve the residue, and the identification reaction of the sodium salt was observed (General rule 0301).
- in the chromatogram recorded under the determination of glycyrrhizic acid content, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the control solution.
examination
should comply with the relevant provisions under the capsule (General rule 0103).
Content determination
- the contents under the item of difference in loading quantity of bismuth shall be mixed uniformly, then the appropriate child (equivalent to 0.3g of bismuth aluminate) shall be accurately weighed, placed in a 50ml crucible, and slowly baked until complete carbonization, cool, add 3ml nitric acid, heat at low temperature until the nitric acid gas is removed, burn to Ash completely, let cool, add 20ml nitric acid solution (3-10), transfer the residue to 500ml Erlenmeyer flask, funnel at the mouth of the bottle was set to reflux with micro-heat until the residue was dissolved (the solution was slightly turbid). After allowing to cool, add 200ml of water and 5 drops of Xylenol Orange indicator solution, with ethylenediamine tetraacetic acid disodium titration solution (0.05mol/L) titration solution from orange to lemon yellow. Per 1 ml of disodium ethylenediaminetetraacetate titration solution (0.05mol/L) corresponds to 10.45mg of bismuth (Bi).
- aluminum the solution after bismuth determination is taken, ammonia test solution is added dropwise to precipitate the precipitate, and dilute nitric acid is added dropwise to dissolve the precipitate (pH value is about 6), add 15ml of ammonium acetate buffer (pH 6.0), add 50ml of ethylenediamine tetraacetic acid disodium titration solution (0.05mol/L), boil for 10 minutes, cool, add 5 drops of Xylenol Orange indicator solution, titration with zinc titration solution (0.05mol/L) until the solution changes from lemon yellow to orange, each 1 ml of ethylene diamine tetraacetic acid disodium titration solution (0.05mol/L) corresponds to 1.349mg of aluminum (A1).
- precise weighing of magnesium oxide an appropriate amount of the above uniformly mixed content (approximately equivalent to 0.4g of heavy magnesium carbonate) was placed in a 50ml crucible, slowly cauterizing until complete carbonization, and cooling, adding 3ml of nitric acid, after heating at low temperature until the nitric acid gas was removed, the residue was completely Ash, cooled, transferred to a 50ml beaker with 15ml of dilute hydrochloric acid, boiled to dissolve the residue, and then added 20ml of water, add 1 drop of Methyl red indicator solution, add ammonia test solution Dropwise to make the red color of the solution disappear, then boil for 5 minutes, filter while hot, wash the filter residue with slightly warm 30% ammonium chloride solution 30ml, combine the filtrate and wash solution, put it in a 100ml measuring flask, let it cool, add water to the scale, shake well, take 20ml precisely, put it in an Erlenmeyer flask, add 20ml water, add ammonia-ammonium chloride buffer (pH10.0) and triethanolamine solution (1-2). Each 5ml, plus a small amount of Chrome Black T indicator, with ethylenediamine tetraacetic acid disodium titration solution (0.05mol/L) titration, to the solution of pure blue. Each 1 ml of ethylene diamine tetraacetic acid disodium titration solution (0.05mol/L) is equivalent to 2.015mg of MgO.
- glycyrrhizic acid was measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica as filler; Methanol -0.2mol/L ammonium acetate solution-glacial acetic acid (67:33:1) as mobile phase; the detection wavelength was 250Nm. The number of theoretical plates shall not be less than 2000 according to the peak of ammonium glycyrrhizinate.
- determination Method: Take the above mixed content, weigh an appropriate amount (about 0.1g of licorice extract), put it in a 50ml measuring flask, add 40ml of mobile phase, sonicate for 30 minutes, and let it cool, dilute to the scale with mobile phase, shake, filter, take the filtrate as the test solution, inject l0ul into the liquid chromatograph with precision, record the chromatogram, and take about 10 mg of ammonium glycyrrhizinate reference substance, same method determination. According to the external standard method to calculate the peak area, and the result is multiplied by 0.9797, that is.
category
antacids.
storage
sealed and stored in a dry place.
Last Update：2022-01-01 13:43:42
Wismut-aluminat - Introduction
Bismuth Aluminate is an inorganic compound with the chemical formula Albio3. The following is a description of the nature, use, formulation and safety information of Bismuth Aluminate:
Nature:
1. Bismuth hydrate is a white crystalline solid, relatively stable.
2. It has high melting point and thermal stability.
3. Insoluble in water at room temperature.
Use:
1. Bismuth alumina is commonly used as a catalyst for organic synthesis reactions, such as oxidation reactions, hydrogenation reactions, etc.
2. Is also used to prepare other aluminate compounds, such as ammonium aluminate, Barium aluminate, etc.
3. Bismuth aluminum can also be used as an additive in the glass and ceramic industries to improve the performance of materials.
Preparation Method:
1. Bismuth aluminum can be prepared by reacting bismuthate and aluminum salt solution. The reaction equation is: Bi(NO3)3 Al(NO3)3 → AlBiO3 3HNO3.
Safety Information:
1. The toxicity of Bismuth alumina is low, but it is still necessary to pay attention to safe operation.
2. Avoid inhaling dust or contact with skin and eyes when in contact with Bismuth hydrate.
3. Wear appropriate protective equipment such as gloves, glasses and masks during operation.
4. Waste shall be disposed according to local regulations and shall not be discarded at will.
Nature:
1. Bismuth hydrate is a white crystalline solid, relatively stable.
2. It has high melting point and thermal stability.
3. Insoluble in water at room temperature.
Use:
1. Bismuth alumina is commonly used as a catalyst for organic synthesis reactions, such as oxidation reactions, hydrogenation reactions, etc.
2. Is also used to prepare other aluminate compounds, such as ammonium aluminate, Barium aluminate, etc.
3. Bismuth aluminum can also be used as an additive in the glass and ceramic industries to improve the performance of materials.
Preparation Method:
1. Bismuth aluminum can be prepared by reacting bismuthate and aluminum salt solution. The reaction equation is: Bi(NO3)3 Al(NO3)3 → AlBiO3 3HNO3.
Safety Information:
1. The toxicity of Bismuth alumina is low, but it is still necessary to pay attention to safe operation.
2. Avoid inhaling dust or contact with skin and eyes when in contact with Bismuth hydrate.
3. Wear appropriate protective equipment such as gloves, glasses and masks during operation.
4. Waste shall be disposed according to local regulations and shall not be discarded at will.
Last Update：2024-04-10 22:29:15
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CAS: 12284-76-3
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Product Name: Bismuth Aluminate Request for quotation
CAS: 12284-76-3
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 12284-76-3
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Spot supply
Product Name: Bismuth Aluminate Request for quotationCAS: 12284-76-3
Tel: 86+027-83389957
Email: 1024042217@qq.com
Mobile: 86+18627766980
QQ: 1024042217
Wechat: 18627766980
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Raw Materials for Wismut-aluminat