Name | Worenine chloride |
Synonyms | Worenin Worenine Berberine Methyl Worenine chloride Berberine Impurity 6 |
CAS | 38763-29-0 |
Molecular Formula | C20H16NO4+ |
Molar Mass | 334.35 |
Solubility | Soluble in methanol, ethanol, DMSO and other organic solvents |
Appearance | Red crystalline powder |
Storage Condition | 2-8℃ |
Physical and Chemical Properties | Red crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Coptis chinensis. |
Reference Show more | 1. [IF=5.787] Ji Lijiang et al."Worenine reverses the Warburg effect and inhibits colon cancer cell growth by negatively regulating HIF-1α."Cell Mol Biol Lett. 2021 Dec;26(1):1-14 2. [IF=4.759] Yi Zhang et al."Screening of inhibitors against histone demethylation jumonji domain-containing protein 3 by capillary electrophoresis."J Chromatogr A. 2020 Feb;1613:460625 3. [IF=1.345] Ya-Li Zhang et al."Coptisine suppresses proliferation and inhibits metastasis in human pancreatic cancer PANC-1 cells."J Asian Nat Prod Res. 2020;22(5):452-463 |
biological activity | Worenine isolated from coptis chinensis. Worenine showed dehydrogenation, hydrogenation, hydroxylation, and demethylation reactions in the first stage metabolism in rats. Phase II metabolism in rats is mainly sulfation and glucuronidation. |
chemical properties | red crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Coptis chinensis. |
use | methyl copberine has the effect of antimicrobial and antigenic insects. used for content determination/identification/pharmacological experiment, etc. |