Name | XY1 |
Synonyms | XY1 XY 1 XY-1 XY 1 XY1 NEW CS-2431 XY-1 (Negative of SGC-707) N-2-Naphthalenyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]urea 1-(naphthalen-2-yl)-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]urea |
CAS | 1624117-53-8 |
Molecular Formula | C17H19N3O2 |
Molar Mass | 297.35 |
Density | 1.284±0.06 g/cm3(Predicted) |
Boling Point | 514.8±42.0 °C(Predicted) |
Solubility | 10 mM in DMSO |
pKa | 12.62±0.46(Predicted) |
Storage Condition | Sealed in dry,Store in freezer, under -20°C |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.363 ml | 16.815 ml | 33.63 ml |
5 mM | 0.673 ml | 3.363 ml | 6.726 ml |
10 mM | 0.336 ml | 1.682 ml | 3.363 ml |
5 mM | 0.067 ml | 0.336 ml | 0.673 ml |
biological activity | XY1 is an inactive analog of SGC707 and can be used as a negative control for sgc707. SGC707 is a potent, selective allosteric inhibitor of the cellular activity of protein arginine methyltransferase-3 (PRMT3) with IC50 and Kd values of 31 nM and 53 nM, respectively. |
Target | Value |
PRMT3 (Cell-free assay) | 31 nM 53 nM(Kd) |