Molecular Formula | C25H27Cl2N3O4 |
Molar Mass | 504.41 |
Density | 1.313±0.06 g/cm3(Predicted) |
Boling Point | 763.3±60.0 °C(Predicted) |
pKa | 13.20±0.30(Predicted) |
Storage Condition | 2-8℃ |
In vitro study | YH239-EE inhibits the growth of p53-MDM2 of cells and wild-type p53 by inhibiting OCI-AML-3 of the interaction. Of the four AML cells (p53 wild-type OCI-AML-3 and MOLM-13,p53 mutant NB4, and p53 deleted HL60), YH239-EE induce cell cycle arrest by activating p53 and downstream targets, and cause efficient apoptosis. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.983 ml | 9.913 ml | 19.825 ml |
5 mM | 0.397 ml | 1.983 ml | 3.965 ml |
10 mM | 0.198 ml | 0.991 ml | 1.983 ml |
5 mM | 0.04 ml | 0.198 ml | 0.397 ml |