Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-FLUOROMETHYLKETONE

Name	Z-DEVD-FMK
Synonyms	Z-DEVD-FMK Z-DEVD-FLUOROMETHYLKETONE Z-ASP-GLU-VAL-ASP-FLUOROMETHYLKETONE Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-FMK Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-CH2F Z-D(OME)E(OME)VD(OME) FLUOROMETHYLKETONE Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-FLUOROMETHYLKETONE Z-ASP(OME)-GLU(OME)-VAL-DL-ASP(OME)-FLUOROMETHYLKETONE
CAS	210344-95-9

Molecular Formula	C30H41FN4O12
Molar Mass	668.66
Density	1.260±0.06 g/cm3(Predicted)
Boling Point	914.2±65.0 °C(Predicted)
Solubility	DMSO/DMF: ≥20 mM
Appearance	White to slightly brown solid
pKa	10.26±0.46(Predicted)
Storage Condition	Inert atmosphere,Store in freezer, under -20°C
Physical and Chemical Properties	Bioactive Z-DEVD-FMK (Caspase-3 Inhibitor) is a specific and irreversible Caspase-3 inhibitor, which can also effectively inhibit caspase-6, caspase-7, caspase-8 and caspase-10.
In vitro study	Z-DEVD-FMK (1-200 μm) inhibited D4-GDI lysis and apoptosis in a concentration-dependent manner. Z-DEVD-FMK reduced ceramide-induced cardiomyocyte death and significantly inhibited caspase 3 activation. Z-DEVD-FMK (100 μm) attenuated OxyHb-induced cell shedding in cultured brain microvascular endothelial cells, reduced activity by caspase-2 and -3, abolished OxyHb-induced DNA helices, and to prevent OxyHb induced PARP cleavage. Z-DEVD-FMK (μm) blocks the MPP-induced increase in caspase-3 enzyme activity. Z-DEVD-FMK dose-dependently blocked 6-OHDA-induced apoptosis with an IC50 of 18 μm.
In vivo study	Z-DEVD-FMK, before and after injury, significantly reduce the apoptosis after trauma, and significantly improve the recovery of neurological function.

WGK Germany

Last Update：2024-01-02 23:10:35

biological activity	Z-DEVD-FMK (Caspase-3 Inhibitor) is a specific and irreversible Caspase-3 inhibitor that can also effectively inhibit caspase-6, caspase-7, caspase-8 and caspase-10.
target	TargetValue Caspase-3
Target	Value
in vitro study	Z-DEVD-FMK (1-200 μM) inhibited D4-GDI lysis and apoptosis in a concentration-dependent manner. Z-DEVD-FMK reduced ceramide-induced myocardial cell death and significantly inhibited caspase 3 activation. Z-DEVD-FMK (100 μM) attenuated OxyHb-induced cell shedding in cultured brain microvascular endothelial cells, decreased caspase-2 and -3 activity, abolished OxyHb-induced DNA helix, and prevented OxyHb-induced PARP cleavage. Z-DEVD-FMK (100 μM) blocked MPP-induced increase in caspase-3 enzyme activity. Z-DEVD-FMK dose-dependent blockade of 6-OHDA-induced apoptosis with an IC50 of 18 μM.
in vivo studies	Z-DEVD-FMK, before and after injury, apoptosis after trauma was significantly reduced, and the recovery of nerve function was significantly improved.

Last Update：2024-04-09 20:52:54

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CAS: 210344-95-9
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Product Name: Z-DEVD-FMK Visit Supplier Webpage Request for quotation
CAS: 210344-95-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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