Molecular Formula | C20H30N2O4 |
Molar Mass | 362.46 |
Density | 1.074±0.06 g/cm3(Predicted) |
Boling Point | 545.6±45.0 °C(Predicted) |
pKa | 11.14±0.46(Predicted) |
Storage Condition | 2-8℃ |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.759 ml | 13.795 ml | 27.589 ml |
5 mM | 0.552 ml | 2.759 ml | 5.518 ml |
10 mM | 0.276 ml | 1.379 ml | 2.759 ml |
5 mM | 0.055 ml | 0.276 ml | 0.552 ml |
biological activity | Z-Ile-Leu-aldehyde (Z-IL-CHO) is a potent, competitive peptide aldehyde inhibitor of gamma-secretase and notch. |
Cell Line: | CD4 + T cells from C57BL/6 mice. MOPC315.BM cells. |
Concentration: | 25 μM. 0, 12, 15 μM. |
Incubation Time: | 24, 48, 72 hours. 24-48 h hours. |
Result: | DownregulateD RORt and IL-17 mRNA expression. Reduced viability and induced apoptosis in MOPC315.BM cells Reduces myeloma-specific paraprotein levels in the MOPC315.BM model. Diminished osteolytic lesions in the MOPC315.BM mice. |
Animal Model: | MOPC315.BM mouse model. |
Dosage: | 10 mg/kg. |
Administration: | Intraperitoneally either for 14 days. |