ZSET-1446
ST101
CAS: 887603-94-3
Molecular Formula: C15H12N2O
ZSET-1446 - Names and Identifiers
| Name | ST101 |
| Synonyms | ST101 ST-101 ST 101 ZSET 1446 ZSET-1446 ST 101(ZSET1446) 1,3-DIHYDRO-2H-SPIRO[IMIDAZO[1,2-A]PYRIDINE-3,2-INDEN]-2-ONE Spiro[imidazo[1,2-a]pyridine-3(2H),2'-[2H]inden]-2-one, 1',3'-dihydro- |
| CAS | 887603-94-3 |
ZSET-1446 - Physico-chemical Properties
| Molecular Formula | C15H12N2O |
| Molar Mass | 236.27 |
| Density | 1.32±0.1 g/cm3(Predicted) |
| Boling Point | 403.4±55.0 °C(Predicted) |
| pKa | 3.13±0.20(Predicted) |
| Storage Condition | 2-8℃ |
| In vitro study | ZSET1446 (100 pM-10 nM) exerts limited effects on the basal neuronal excitability and synaptic transmission. ZSET1446 potentiates the facilitatory effect of nAChR stimulation on sPSC frequency. ZSET1446 potentiates the increase in sIPSC frequency by local application of nicotine (5 µM; 2 minutes) without affecting the basal sIPSC frequency at the range of 10 pM to 1 nM. |
| In vivo study | ZSET1446 enhances object recognition memory in mice and ameliorates cognitive impairment caused by scopolamine in rats. Concomitant administration of subeffective doses of ZSET1446 and memantine significantly ameliorates the cognitive performance in the novel object recognition task in both mice and rats. Moreover, oral administration of ZSET1446 or memantine increases the extracellular level of ACh in the hippocampus as compared with the control. Further, concomitant administration of subeffective doses of ZSET1446 and memantine significantly increases the extracellular level of ACh as compared with the group of ZSET1446 or memantine alone. ZSET1446 (0.002, 0.01, and 0.1 mg/kg, p.o.) ameliorates cognitive deficits of SAMP8 after 4, 8, 12, and 16 weeks of treatment in a novel object recognition test. ZSET1446 also reduces grading scores of SAMP8 after 16 weeks of treatment. Further, 8-week treatment of ZSET1446 significantly reduces the total number of Aβ-positive granules in the hippocampus. |
ZSET-1446 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.232 ml | 21.162 ml | 42.324 ml |
| 5 mM | 0.846 ml | 4.232 ml | 8.465 ml |
| 10 mM | 0.423 ml | 2.116 ml | 4.232 ml |
| 5 mM | 0.085 ml | 0.423 ml | 0.846 ml |
Last Update：2024-01-02 23:10:35
ZSET-1446 - Reference Information
| biological activity | ZSET1446 is a novel cognitive drug, can improve learning dysfunction. |
Last Update：2024-04-09 21:11:58
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Product Name: ST101 Visit Supplier Webpage Request for quotation
CAS: 887603-94-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 887603-94-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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