ZYZ-488
ZYZ-488
CAS: 1470302-79-4
Molecular Formula: C20H29N3O11
ZYZ-488 - Names and Identifiers
| Name | ZYZ-488 |
| Synonyms | ZYZ-488 β-D-Glucopyranosiduronic acid, 4-[[4-[(aminoiminomethyl)amino]butoxy]carbonyl]-2,6-dimethoxyphenyl |
| CAS | 1470302-79-4 |
ZYZ-488 - Physico-chemical Properties
| Molecular Formula | C20H29N3O11 |
| Molar Mass | 487.46 |
| Density | 1.57±0.1 g/cm3(Predicted) |
| Boling Point | 700.6±70.0 °C(Predicted) |
| pKa | 2.75±0.70(Predicted) |
| Storage Condition | 2-8°C，惰性气体保存 |
| In vitro study | ZYZ-488 decreases apoptosis in hypoxic H9c2 cells. ZYZ-488 inhibits hypoxia induced Apaf-1-mediated activation of procaspase-9 and procaspase-3. ZYZ-488 decreases myocardial enzyme release, inhibits cardiomyocyte apoptosis, and suppresses the activation of the downstream cascade of caspases. |
ZYZ-488 - Reference Information
| biological activity | ZYZ-488 is a competitive inhibitor of apoptotic protease activating factor -1 (Apaf-1), inhibition of activation of binding proteins procaspase-9 and procaspase-3. |
| Target | apotative protein activating factor-1 |
| Animal Model: | Male C57BL/6 mice (8-10 weeks old) |
| Dosage: | myocardial infarction + ZYZ-488 (33.9 mg/kg); myocardial infraction + ZYZ-488 (67.8 mg/kg); |
| Administration: | Intramuscularly; for 3 days |
| Result: | Inhibited Apaf-1-mediated activation of procaspase-9 and procaspase-3. |
Last Update：2024-04-09 20:02:46
