Zafirlukast
Zafirlukast
CAS: 107753-78-6
Molecular Formula: C31H33N3O6S
Zafirlukast - Names and Identifiers
Zafirlukast - Physico-chemical Properties
| Molecular Formula | C31H33N3O6S |
| Molar Mass | 575.68 |
| Density | 1.32±0.1 g/cm3(Predicted) |
| Melting Point | 139°C |
| Solubility | DMSO: ≥28mg/mL |
| Appearance | solid |
| Color | White or pink |
| Merck | 14,10108 |
| pKa | 4.94±0.10(Predicted) |
| Storage Condition | room temp |
| Stability | Stable for 2 years as supplied. Protect from exposure to moisture. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Refractive Index | 1.64 |
| Physical and Chemical Properties | Melting Point: 139°C |
Zafirlukast - Risk and Safety
| WGK Germany | 3 |
| RTECS | FB3966200 |
Zafirlukast - Nature
Open Data Verified Data
A white solid was obtained from methanol, melting point 138-140 °c. Slightly soluble in methanol, soluble in Tetrahydrofuran, acetone, dimethyl sulfoxide, almost insoluble in water.
Last Update：2024-01-02 23:10:35
Zafirlukast - Preparation Method
Open Data Verified Data
5 Nitro indole and 4-(bromomethyl)-3-methoxybenzoic acid methyl ester dissolved in dioxane, ammonia protection and stirring with the addition of silver oxide, under certain conditions, the yellow oil obtained by the treatment was further crystallized from dichloromethane-hexane to obtain the compound. Under the protection of nitrogen, the compound is added to the suspension of sodium hydride in Tetrahydrofuran, and after a certain period of time, methyl iodide is added to react. The treated compound is dissolved in Tetrahydrofuran, and palladium-carbon catalyst is added, after the reaction, the obtained product and N-methyl morpholine are dissolved in methylene chloride, cyclopentyl chloroformate is added under the protection of nitrogen to react, the compound obtained by treatment is hydrolyzed, The hydrolysate and O-methyl benzene sulfonamide, condensation in dichloromethane in the presence of 1-[3-(dimethylamino) propyl]-3-ethylcarbodiimide hydrochloride and 4-(dimethylamino) pyridine affords zavast.
Last Update：2022-01-01 09:23:03
Zafirlukast - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.737 ml | 8.685 ml | 17.371 ml |
| 5 mM | 0.347 ml | 1.737 ml | 3.474 ml |
| 10 mM | 0.174 ml | 0.869 ml | 1.737 ml |
| 5 mM | 0.035 ml | 0.174 ml | 0.347 ml |
Last Update：2024-01-02 23:10:35
Zafirlukast - Use
Open Data Verified Data
developed by Zeneca, UK, launched in Ireland in 1996. Leukotriene antagonists. For the treatment of asthma.
Last Update：2022-01-01 09:23:03
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Spot supply
Product Name: Zafirlukast Visit Supplier Webpage Request for quotationCAS: 107753-78-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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