ZoledronicacidforInjection
Zoledronic acid hydrate
CAS: 165800-06-6
Molecular Formula: C5H12N2O8P2
ZoledronicacidforInjection - Names and Identifiers
| Name | Zoledronic acid hydrate |
| Synonyms | Zoledronic acid hydrate zoledronic acid hydrate ZoledronicacidforInjection ZOLEDRONIC ACID MONOHYDRATE (1-hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid monohydrate (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl)phosphonic acid hydrate [1-HYDROXY-(1H-IMIDAZOL-1-YL)-PHOSPHONOETHYL] PHOSPHONIC ACID MONOHYDRATE PHOSPHONIC ACID, [1-HYDROXY-2-(1H-IMIDAZOL-1-YL)ETHYLIDENE]BIS-, MONOHYDRATE [1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) monohydrate |
| CAS | 165800-06-6 |
| InChI | InChI=1/C5H10N2O7P2.H2O/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7;/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14);1H2 |
| InChIKey | FUXFIVRTGHOMSO-UHFFFAOYSA-N |
ZoledronicacidforInjection - Physico-chemical Properties
| Molecular Formula | C5H12N2O8P2 |
| Molar Mass | 290.1 |
| Melting Point | 245 °C(dec.) |
| Boling Point | 764°C at 760 mmHg |
| Flash Point | 415.8°C |
| Solubility | H2O: ≥2mg/mL |
| Vapor Presure | 1.53E-24mmHg at 25°C |
| Appearance | White-like crystal |
| Color | white to beige |
| Merck | 14,10187 |
| Storage Condition | 2-8°C |
ZoledronicacidforInjection - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | SZ8562450 |
| HS Code | 29332900 |
ZoledronicacidforInjection - Reference Information
| Biological activity | Zoledronic acid (Zoledronate, CGP-4244) monohydrate is a monohydrate of Zoledronic acid (zoledronic acid), which is an effective osteoclast Inhibitor can induce osteoclast apoptosis by inhibiting enzymes of the mevale dihydroxyacid pathway and preventing isoprene of small GTP-binding proteins such as Ras and Rho. |
| Target | Value |
| Cell Line: | MC3T3-E1 cells MC3T3-E1 cells MC3T3-E1 cells |
| Concentration: | 0.02 µM , 0.1 µM, 1 µM, 10 µM, 100 µM 0.02 µM , 0.1 µM, 1 µM, 10 µM, 100 µM 0.02 µM , 0.1 µM, 1 µM, 10 µM, 100 µM |
| Incubation Time: | 1 day, 3 days, 5 days, 7 days 1 days, 4 days, 7 days 4 days |
| Result: | Reduced cells viability at 10 µM and 100 µM. Increased the number of early apoptotic cells and late apoptotic or necrotic cells at dose-dependent and time-dependent (high concentrations). Down-regulated the protein level of inactive caspase-3 and up-regulated the protein level of active caspase-3 at the concentrations of 10 and 100 µM. Inhibited both osteoclast and osteoblasts function and bone remodeling at 0.5 mg/kg and 1 mg/kg. |
| Animal Model: | Five-week-old C57BL6 mice |
| Dosage: | 0.05 mg/kg, 0.5 mg/kg, 1 mg/kg |
| Administration: | Intraperitoneal injection, weekly, for 3 weeks |
Last Update：2024-04-10 22:29:15
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Multiple SpecificationsSpot supply
Product Name: Zoledronate monohydrate; CGP 42446 monohydrate; CGP42446A monohydrate; ZOL 446 monohydrate Visit Supplier Webpage Request for quotationCAS: 165800-06-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Zoledronic Acid Monohydrate Visit Supplier Webpage Request for quotationCAS: 165800-06-6
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Zoledronic Acid Monohydrate Visit Supplier Webpage Request for quotationCAS: 165800-06-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Zoledronic acid monohydrate Visit Supplier Webpage Request for quotationCAS: 165800-06-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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