a-(diethylamino)-26-acetoxylidideHCl
lidocaine hydrochloride
CAS: 73-78-9
Molecular Formula: C14H23ClN2O
a-(diethylamino)-26-acetoxylidideHCl - Names and Identifiers
a-(diethylamino)-26-acetoxylidideHCl - Physico-chemical Properties
| Molecular Formula | C14H23ClN2O |
| Molar Mass | 270.8 |
| Melting Point | 80-82°C |
| Boling Point | 350.8°C at 760 mmHg |
| Flash Point | 166°C |
| Vapor Presure | 4.28E-05mmHg at 25°C |
| Storage Condition | Inert atmosphere,2-8°C |
| Physical and Chemical Properties | White Crystal, odorless, slightly bitter and Hemp taste. Very soluble in water, ethanol and organic solvents, but insoluble in ether. Aqueous solution in the case of acid, alkali does not decompose, repeated high-pressure sterilization rarely deterioration. |
| Use | Local anesthetics, antiarrhythmic drugs, for a variety of anesthesia and rapid ventricular arrhythmias |
a-(diethylamino)-26-acetoxylidideHCl - Risk and Safety
| UN IDs | 3249 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 oral in mouse: 220mg/kg |
a-(diethylamino)-26-acetoxylidideHCl - Standard
Authoritative Data Verified Data
This product is N-(2, 6-xylyl)-2-(diethylamino) acetamide hydrochloride monohydrate. The content of C14H22N20 • HCl should be between 98.0% and 102.0% based on the anhydrous content.
Last Update：2024-01-02 23:10:35
a-(diethylamino)-26-acetoxylidideHCl - Trait
Authoritative Data Verified Data
- This product is white crystalline powder; Odorless.
- This product is soluble in water or ethanol, soluble in chloroform, insoluble in ether.
melting point
The melting point of this product (General rule 0612 first method) is 75~79°C.
Last Update：2022-01-01 15:04:59
a-(diethylamino)-26-acetoxylidideHCl - Differential diagnosis
Authoritative Data Verified Data
- take 0.2g of this product, add 20ml of water to dissolve, take 2ml of solution, add 0.2ml of copper sulfate test solution and 1ml of sodium carbonate test solution, that is blue-purple; Add 2ml of chloroform, shake and place, the chloroform layer was yellow.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 357).
- the aqueous solution of this product was chloride identification (1) of the reaction (General 0301).
Last Update：2022-01-01 15:05:00
a-(diethylamino)-26-acetoxylidideHCl - Exam
Authoritative Data Verified Data
acidity
take 0.20g of this product, add 40ml of water to dissolve, and then measure it according to law (General rule 0631). The pH value should be 4.0~5.5.
clarity of the solution
take l.Og of this product, Add 10ml of water to dissolve, the solution should be clear; If it is turbid, compared with No. 1 turbidity standard solution (General rule 0902 first method), it should not be more concentrated.
sulfate
take 0.2g of this product, add 20ml of water to dissolve, add 2ml of dilute hydrochloric acid, shake, divide into 2 equal parts; Add 1ml of water, shake, as a control solution; 1ml of 25% barium chloride solution was added to the other portion, and the mixture was shaken well. Compared with the control solution, 2, 6-dimethylaniline with more concentration was not allowed to be used. Take an appropriate amount of this product, add the mobile phase to dissolve and make a solution containing 5mg per 1 ml, as a test solution; Take an appropriate amount of 2, 6-dimethylaniline control, precision weighing, the mobile phase was added to dissolve and quantitatively dilute to prepare a solution containing 0.5ug of 2, 6-dimethylaniline per 1 ml, which was used as a reference solution, the mobile phase was added and dissolved and diluted to prepare a solution containing about 50ug per 1ml as a system-suitable solution. According to the chromatographic condition test under the content determination item, the detection wavelength is 230mn, and the system applicable solution 20u1 is injected into the human liquid chromatograph, and the chromatogram is recorded, the separation of 6-dimethylaniline peak and lidocaine peak should meet the requirements. 20 u1 of the reference solution and the test solution were respectively injected into the liquid chromatograph, and the chromatograms were recorded. If there is a peak of 2, 6-dimethylaniline in the chromatogram of the test solution, the peak area shall be calculated according to the external standard method, and the peak area shall not exceed 0.01%.
moisture
take this product, according to the determination method of moisture (General 0832 first method 1), the water content is divided into 5.0% ~ 7.5%.
ignition residue
not more than 0.1% (General rule 0841).
Heavy metals
take this product 2. G, add acetate buffer (pH 3.5)2ml and water appropriate amount to dissolve into 25ml, according to the law (General Principles 0821 The first law), containing heavy metals shall not exceed 10 parts per million.
Last Update：2022-01-01 15:05:01
a-(diethylamino)-26-acetoxylidideHCl - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General 0512).
chromatographic conditions and system suitability test
silica gel bonded with octylsilane as filler; Phosphate buffer solution (1 mol/L sodium dihydrogen phosphate solution 32.5ml and 0.5mol /L disodium hydrogen phosphate solution ml, diluted with water, shake)-Acetonitrile (50:50)(adjusted to pH 8.0 with phosphoric acid) as mobile phase; Detection wavelength 254nm. The number of theoretical plates is not less than 2000 based on the lidocaine peak.
assay
take an appropriate amount of this product, accurately weigh it, add mobile phase to dissolve and quantitatively dilute it to make a solution containing about 2mg per lml. Take 20m1 for injection into human liquid chromatography with precision and record the chromatogram; another control sample of lidocaine was determined by the same method. According to the external standard method to calculate the peak area, and the result is multiplied by 1.156, that is.
Last Update：2022-01-01 15:05:01
a-(diethylamino)-26-acetoxylidideHCl - Category
Authoritative Data Verified Data
local anesthetic and antiarrhythmic drugs.
Last Update：2022-01-01 15:05:02
a-(diethylamino)-26-acetoxylidideHCl - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 15:05:02
a-(diethylamino)-26-acetoxylidideHCl - Lidocaine Hydrochloride Injection
Authoritative Data Verified Data
This product is a sterile aqueous solution of lidocaine hydrochloride. Lidocaine hydrochloride (C14H22N20 • HCl) should be included in 95.0% to 105.0% of label load.
trait
This product is a clear colorless liquid.
identification
- The product was taken, and the same results were shown in the test of (1) and (3) under the item of lidocaine hydrochloride.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
examination
- the pH value should be 4.0 to 6.0 (General 0631).
- precise amount of related substances: Take appropriate amount of this product and quantitatively dilute it with mobile phase to prepare a solution containing about 2mg of lidocaine hydrochloride per 1 ml as the test solution, in a 100ml measuring flask, dilute with mobile phase to the scale, and use as a control solution; Take another 2, 6-dimethylaniline reference substance and weigh it accurately, the mobile phase was added to dissolve and dilute to prepare a solution containing about 0.8ug per 1 ml as a control solution. According to the chromatographic conditions under the content determination item, the detection wavelength is 230nm, and 20 u1 of each of the above three solutions are injected into the liquid chromatograph respectively, and the chromatogram is recorded to 3.5 times of the retention time of the main component peak, if there are chromatographic peaks in the chromatogram of the test solution that are consistent with the retention time of 2, 6-dimethylaniline, the peak area shall be calculated according to the external standard method and shall not exceed 0.04%, other single impurity peak area shall not be greater than 0.5 times (0.5%) of the main peak area of the control solution, and the sum of other impurity peak areas shall not be greater than the main peak area of the control solution (1.0%).
- The osmolality shall be 0632-310mOsmol/kg when the product is taken for inspection according to law (General rule 285).
- bacterial endotoxin to take this product, according to the law (General 1143), each 1 mg lidocaine hydrochloride containing endotoxin should be less than 1.0 EU; For intrathecal injection should be less than 0.040EU.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; Phosphate buffer (1 mol/L sodium dihydrogen phosphate solution 0.5 ml and 32.5 mol/L disodium hydrogen phosphate solution ml, in a 1000ml measuring flask, dilute to the scale with water, shake well)-acetonitrile (50:50) was adjusted to pH 8.0 with phosphoric acid as the mobile phase; The detection wavelength was 254nm. The number of theoretical plates is not less than 2000 based on the lidocaine peak.
- precision measurement: take an appropriate amount of this product (about equivalent to lidocaine hydrochloride lOOmg), put it in a 50ml measuring flask, dilute it to the scale with the mobile phase, shake it well, and use it as a test solution, record chromatogram with 20ul injection liquid chromatograph; Take the lidocaine reference product about 85mg, weigh it accurately, put it in 50ml measuring flask, add 0.5ml of 1 mol/L hydrochloric acid solution to dissolve it, diluted with mobile phase to the scale, shake, the same method. According to the external standard method to calculate the peak area, and multiplied by 1.156, that is.
category
Same as lidocaine hydrochloride.
specification
(l)2ml:20mg (2)2ml:40mg (3)3.5ml:35mg (4)5ml:50mg (5)5ml:0.lg (6) 10ml:0.2g(7)20ml:0.4g
storage
sealed storage.
Last Update：2022-01-01 15:05:03
a-(diethylamino)-26-acetoxylidideHCl - Lidocaine Hydrochloride Injection
Authoritative Data Verified Data
This product is a sterile aqueous solution of lidocaine hydrochloride. Lidocaine hydrochloride (C14H22N20 • HC1) shall be present at 95.0% to 105.0% of the labeled amount.
trait
This product is a clear colorless liquid.
identification
- take 2ml of this product, add 0.2ml of copper sulfate test solution and lml of sodium carbonate test solution, which is blue-purple; Add 2ml of chloroform, shake and place, and the trichloromethane layer is yellow.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- This product chloride identification (1) of the reaction (General 0301).
examination
- the pH value should be 3.5 to 5.5 (General 0631).
- precise amount of related substances take appropriate amount of this product, add mobile phase to dissolve and dilute to prepare a solution containing about 2mg per 1 ml as a test solution; take 1.0ml of the test solution, put it in a 100ml measuring flask, dilute it to the scale with mobile phase, and use it as a control solution. Take an appropriate amount of 2, 6-dimethylaniline reference, and weigh it accurately, add the mobile phase to dissolve and dilute to make a solution containing about 0.8ug per lml, which is used as a reference solution. According to the chromatographic conditions under the content determination item, take 20 u1 of each of the above solutions respectively and inject it into the human liquid chromatograph, record the chromatogram to 3.5 times of the retention time of the main component. If there are chromatographic peaks in the chromatogram of the test solution that are consistent with the retention time of 2, 6-dimethylaniline, the peak area shall be calculated according to the external standard method, and shall not exceed 0.04%, the sum of the peak areas of other impurities shall not be greater than the main peak area of the control solution (1.0%).
- bacterial endotoxin this product, according to the law to check (General 1143), each lml lidocaine hydrochloride injection containing endotoxin should be less than 1.0 EU.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; Phosphate buffer (1 mol/L sodium dihydrogen phosphate solution 0.5 ml and 32.5 mol/L disodium hydrogen phosphate solution ml, in a 1000ml measuring flask, dilute with water to the scale, shake well)-acetonitrile (50:50)(adjust pH to 8.0 with phosphoric acid) as mobile phase; The detection wavelength was 254nm, the number of theoretical plate should not be less than 2000 according to the calculation of lidocaine peak.
- precision measurement: take an appropriate amount of this product (about equivalent to lidocaine hydrochloride lOOmg), put it in a 50ml measuring flask, dilute it to the scale with the mobile phase, shake it well, and use it as a test solution, record chromatogram with 20u1 injection and record chromatogram; Take lidocaine reference product about 85mg, weigh it accurately, put it in 50ml measuring flask, add 0.5ml hydrochloric acid solution of lmol/L to dissolve, diluted with mobile phase to the scale, shake, the same method. According to the external standard method to calculate the peak area, and multiplied by 1.156, that is.
category
Same as lidocaine hydrochloride.
specification
(l)2ml:4mg (2)5ml:1Omg
storage
sealed storage.
Last Update：2022-01-01 15:05:04
a-(diethylamino)-26-acetoxylidideHCl - Lidocaine Hydrochloride Mucilage (I)
Authoritative Data Verified Data
This product is the sterilization of lidocaine hydrochloride mucilage. Lidocaine hydrochloride (C14H22N20 • HC1) shall be present at 95.0% to 105.0% of the labeled amount.
trait
This product is colorless to yellowish viscous liquid.
identification
- take about 10g of this product, dilute with 20ml of water, take 2ml of solution, add 0.2ml of copper sulfate test solution and 1ml of sodium carbonate test solution, that is blue-purple, add 2ml of chloroform, shake and place, the chloroform layer was yellow.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- take an appropriate amount of this product (about 0.3g of lidocaine hydrochloride), put it in a separatory funnel, add 15ml of water, shake to dissolve, add 4ml of 6mol/L ammonia solution, and extract 4 times with chloroform, 15ml each time, the chloroform solution was combined and filtered through a filter with cotton wool and anhydrous sodium sulfate. The filtrate was evaporated to dryness and dissolved by adding n-hexane, the infrared absorption spectrum was determined to be consistent with that of the control (General 0402).
- the reaction of (1) was identified by taking the aqueous solution obtained in the identification (1) and showing chloride (General 0301).
examination
- the pH value should be 6.0 to 7.0 (General 0631).
- sterile take this product, inspection according to law (General 1101), should comply with the provisions.
- others shall comply with the relevant provisions under the item of gel (General rule 0114).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; Phosphate buffer (1 mol / L sodium dihydrogen phosphate solution 0.5 ml and 32.5 mol / L disodium hydrogen phosphate solution ml, dilute with water to (1000ml, shake up)-acetonitrile (50:50) (adjust pH to 8.0 with phosphoric acid) as mobile phase with detection wavelength of 254mn. The number of theoretical plate should not be less than 2000 according to the calculation of lidocaine peak.
- determination: take an appropriate amount of this product (about 100mg equivalent to docaine hydrochloride), weigh it accurately, put it in a 50ml measuring flask, dilute it to the scale with mobile phase, shake it well, and use it as a test solution, 20u1 was injected into the liquid chromatograph for accurate measurement, and the chromatogram was recorded. An appropriate amount of lidocaine reference substance was taken for accurate weighing and determination by the same method. According to the external standard method to calculate the peak area, and the result is multiplied by 1.156, that is.
category
Same as lidocaine hydrochloride.
specification
(l)10g:0.2g (2)20g:0.4g
storage
sealed storage.
Last Update：2022-01-01 15:05:05
a-(diethylamino)-26-acetoxylidideHCl - Lidocaine hydrochloride gel
Authoritative Data Verified Data
This product is a sterile gel of lidocaine hydrochloride. Lidocaine hydrochloride (C14H22N20 • HCl) should be included in 95.0% to 105.0% of label load.
trait
This product is colorless or almost colorless viscous liquid.
identification
- take about 10ml of this product, add 20ml of water to dilute it, take 2ml of solution, add 0.2ml of copper sulfate solution and 1ml of sodium carbonate solution, that is blue-purple, add 2ml of chloroform, shake it and place it, the chloroform layer was yellow.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- the aqueous solution under identification (1) was taken to show the reaction of chloride identification (1) (General 0301).
examination
- the pH value should be 5.0 to 7.0 (General 0631).
- 2, 6-dimethylaniline is a new product for use. Take an appropriate amount of this product (about 100mg equivalent to lidocaine hydrochloride), weigh it accurately, put it in a 20ml measuring flask, add the mobile phase to dissolve and dilute to the scale, shake it, and use it as a test solution, the appropriate amount of 6-dimethylaniline reference substance was precisely weighed, dissolved and quantitatively diluted with mobile phase to prepare 2ug solution per lml as reference solution, the 6-dimethylaniline control was dissolved and diluted by adding the mobile phase to prepare a solution containing about 5mg and 2ug per 1 ml, respectively, as a system applicable solution. If there is a peak of 2, 6-dimethylaniline in the chromatogram of the test solution, the peak area shall be calculated according to the external standard method, 6-dimethylaniline should not exceed 0.04% of the labeled dose of lidocaine hydrochloride.
- others shall comply with the relevant provisions under the item of gel (General rule 0114).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; Phosphate buffer solution (1 mol/L sodium dihydrogen phosphate solution l.3ml and 0.5mol/L disodium hydrogen phosphate solution 32.5ml, dilute with water to 1000ml, Shake)-acetonitrile (50:50)(adjust pH to 8.0 with phosphoric acid) as mobile phase, the detection wavelength was 254nm. The number of theoretical plates is not less than 2000 based on the lidocaine peak.
- determination: take an appropriate amount of this product (about 40mg equivalent to lidocaine hydrochloride), weigh it accurately, put it in a 20ml measuring flask, dissolve it with mobile phase, dilute it to the scale, shake it well, centrifuge it, the supernatant was taken as the test solution, and 20 u1 was accurately measured and injected into the liquid chromatograph to record the chromatogram, the mobile phase was added to dissolve and quantitatively dilute to a solution containing about 2mg of lidocaine hydrochloride per 1 ml, which was determined by the same method. According to the external standard method to calculate the peak area, that is.
category
Same as lidocaine hydrochloride.
specification
(l)10ml:0.2g (2)20ml:0.4g
storage
sealed storage.
Last Update：2022-01-01 15:05:06
a-(diethylamino)-26-acetoxylidideHCl - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| local anesthetic and antiarrhythmic drug | lidocaine hydrochloride was used as local anesthetic and antiarrhythmic drug. Clinically, it is mainly used for infiltration anesthesia, epidural anesthesia, surface anesthesia (including mucosal anesthesia during thoracoscopy or abdominal surgery) and nerve conduction block. It can also be used for ventricular premature beats and ventricular tachycardia after acute myocardial infarction. It can also be used for Digitalis poisoning, cardiac surgery and ventricular arrhythmia caused by cardiac catheterization. But it is usually not effective for supraventricular arrhythmias. lidocaine hydrochloride is an amide local anesthetic. After blood absorption or intravenous administration, the central nervous system has obvious excitation and inhibition of biphasic effect, and can be no precursor of excitation, low blood concentration, analgesia and drowsiness, the pain threshold increases; With the increase of dose, the effect or toxicity increases, and the blood concentration of the sub-toxic drug has anticonvulsant effect; When the blood concentration exceeds 5 μg · ml-1, convulsions can occur. Lidocaine hydrochloride in low dose, can promote the outflow of K in myocardial cells, reduce myocardial automaticity, and has the effect of anti ventricular arrhythmia; In the treatment of dose, the electrical activity of myocardial cells, atrioventricular conduction and myocardial contraction had no significant effect; Further increase in blood concentration, can cause heart conduction velocity slowed, atrioventricular block, inhibit myocardial contractility and cardiac output decreased. |
| function and use | lidocaine hydrochloride has the characteristics of strong penetration, strong diffusion, fast onset, 2 times of anesthetic efficacy and procaine, and the toxicity was 1. The anesthetic effect can appear 5 minutes after administration, and the anesthetic effect can last for 1~1.5 hours, which is 50% longer than procaine. After absorption can inhibit the central nervous system, and can inhibit ventricular automaticity, shorten the refractory period, can be used to control ventricular tachycardia, ventricular premature beats, ventricular tachycardia and ventricular fibrillation and other arrhythmia symptoms. It is effective for cardiac disorders or cardiac arrhythmias caused by cardiac glycosides, but not for supraventricular tachycardia. This product is fast, short duration, oral invalid, often as intravenous administration. |
| indication | lidocaine hydrochloride is an intermediate amide local anesthetic. It is used as local anesthetic and antiarrhythmic drug. Mainly used for: (1) infiltration anesthesia, epidural anesthesia, surface anesthesia (including in thoracoscopy or abdominal surgery for mucosal anesthesia) and nerve conduction block. (2) to treat ventricular premature beat and ventricular tachycardia after acute myocardial infarction (AMI), and ventricular arrhythmia caused by digitalis poisoning, cardiac surgery and cardiac catheterization, but it is usually not effective for supraventricular arrhythmias. |
| usage and dosage | topical anesthesia with 2%~ 5% solution. Infiltration anesthesia with 0.25% ~ 0.5% solution. Conduction anesthesia with 2% hydrochloric acid solution, each injection point, horses, cattle 8~12 ml, sheep 3~4 ml. Epidural anesthesia 2% solution, horses, cattle 8~12 ml, dogs, cats, 0.22 per kilogram of body weight. Subcutaneous injection of 2% solution, the maximum amount, pigs, sheep 80 ml, horses, cattle 400 ml, dogs 25 ml, cats 8.5 ml. treatment of arrhythmia, intravenous injection: the initial dose of 2~4 mg per kilogram of body weight in dogs, followed by intravenous infusion of 25~75 micrograms per minute, the initial dose of 250~500 micrograms in cats, this was followed by an intravenous infusion of 20 micrograms per minute. |
| adverse reactions | the incidence of adverse reactions of lidocaine hydrochloride was about 6.3%. Most adverse reactions are dose-related. Adverse reactions are drowsiness, dizziness, dizziness, Nausea, Vomit, burnout, euphoria, confusion, muscle twitching, convulsions, blurred vision, confusion and Dyspnea, high dose can produce severe sinus bradycardia, cardiac arrest, severe atrioventricular block and decreased myocardial contractility, decreased blood pressure, etc. High concentration of lidocaine hydrochloride in blood can cause slow atrial conduction velocity, atrioventricular block (A-V-B), inhibition of myocardial contractility and decrease of cardiac output. A small number of allergic reactions such as erythema rash and vascular nerve edema. |
| drug interaction | (1) cimetidine and β-blockers can inhibit the hepatic metabolism of lidocaine, to increase its blood concentration, adverse reactions can occur in the heart and nervous system, should adjust the dose of lidocaine hydrochloride. (2) barbiturates can promote the metabolism of lidocaine hydrochloride, and the combination of the two drugs can cause bradycardia and sinus arrest. (3) combined with procainamide, can produce a transient delirium and hallucinations, but does not affect the blood concentration of the product. (4) isoproterenol can increase the total clearance rate of this product due to increased hepatic blood flow; Norepinephrine can decrease the total clearance rate of lidocaine hydrochloride due to reduced hepatic blood flow. (5) with the following drugs are incompatible: phenobarbital, thiopental sodium, sodium nitroprusside, mannitol, amphotericin B, ampicillin, sulfadiazine. |
| note | (1) those allergic to other local anesthetics may also be allergic to lidocaine hydrochloride. (2) the following conditions should be used with caution: Pregnancy, newborns, especially premature infants, decreased hepatic blood flow, liver and kidney dysfunction, congestive heart failure, severe myocardial damage, hypovolemia and Shock. (3) strictly control the concentration and the total amount of medication, excessive can cause convulsions and cardiac arrest; The metabolism in the body is slower than procaine, there is accumulation, can cause poisoning and convulsions. (4) the dosage should be adjusted according to the needs and tolerance of the elderly, and the dose should be halved in patients over 70 years old. (5) during anesthesia, it is necessary to prevent the blood vessel and local anesthetic poisoning. (6) the treatment of arrhythmia should pay attention to monitoring blood pressure, ECG, and with rescue equipment; Electrocardiogram P-R interval prolongation or QRS wave broadening, patients with other arrhythmias or previous arrhythmias should be discontinued immediately. (7) during anesthesia, the P-R interval of ECG was prolonged or the QRS wave was widened, and the patients with other arrhythmia or the original arrhythmia should be discontinued immediately. |
| Use | Local anesthetics, antiarrhythmic drugs, for all kinds of anesthesia and rapid ventricular arrhythmia |
Last Update：2024-04-09 02:00:11
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Product Name: Lidocaine hydrochloride Request for quotationCAS: 73-78-9
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Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: 13651600618
WhatsApp: +8613651600618
Spot supply
Product Name: Lidocaine Hydrochloride Visit Supplier Webpage Request for quotationCAS: 73-78-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: lidocaine hydrochloride Request for quotation
CAS: 73-78-9
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Email: sales@tnjchem.com
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Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
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CAS: 73-78-9
Tel: 0086-551-65418684
Email: sales@tnjchem.com
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Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
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