adenine-riboflavindinuceotide
FLAVIN ADENINE DINUCLEOTIDE
CAS: 146-14-5
Molecular Formula: C27H33N9O15P2
adenine-riboflavindinuceotide - Names and Identifiers
| Name | FLAVIN ADENINE DINUCLEOTIDE |
| Synonyms | FAD flavitan adenine-flavindinucleotide adenine-flavinedinucleotide FLAVIN ADENINE DINUCLEOTIDE adenine-riboflavindinuceotide riboflavin-adeninedinucleotide isoalloxazine-adeninedinucleotide riboflavin5'-(trihydrogendiphosphate),5'-5'-esterwithadenosine riboflavin5'-(trihydrogendiphosphate),5'-5'-esterwithadenosine riboflavin5'-(trihydrogendiphosphate),5'.fwdarw.5'-esterwithadenosine riboflavin5'-(trihydrogendiphosphate),5'.fwdarw.5'-esterwithadenosine |
| CAS | 146-14-5 |
| EINECS | 205-663-1 |
adenine-riboflavindinuceotide - Physico-chemical Properties
| Molecular Formula | C27H33N9O15P2 |
| Molar Mass | 785.55 |
| Density | 2.08±0.1 g/cm3(Predicted) |
| Appearance | powder |
| Color | orange |
| Merck | 4091 |
| pKa | 1.13±0.50(Predicted) |
| Storage Condition | −20°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Physical and Chemical Properties | Orange-yellow powder, hygroscopic, easily soluble in water, insoluble in ethanol, the aqueous solution is yellow-green fluorescent, and it decomposes into riboflavin in case of alkali. |
| Use | It is suitable for skin and mucous membrane diseases, nervous tinnitus, cerebral arteriosclerosis, intractable Head Pain, cirrhosis, jaundice and other liver diseases, eye diseases and retinal diseases. Transient chest discomfort was noted after too fast intravenous injection. |
| In vitro study | Poly(Flavin adenine dinucleotide, FAD) characterized by an additional polymer-type redox reaction is a highly effective electrocatalyst for NADH oxidation: operating at the lowest potentials reported for NADH transducers (0.00 V, pH 7.4), poly(FAD) is characterized by the electrochemical rate constant of 1.8 ± 0.6×10 -3 cm/s, which is at the level of the NADH mass-transfer constant. Poly(FAD)-modified electrodes are characterized by the dramatically improved stability and, is the most advantageous NADH transducers for analytical chemistry. |
| In vivo study | Flavin adenine dinucleotide (2 mg/kg, i.v.) significantly cancels chlorpromazine (CPZ)-induced decrease in ventricular fibrillation threshold (VFT). Flavin adenine dinucleotide cancels the effect of CPZ on canine heart mitochondria. After injection of Flavin adenine dinucleotide, the dogs show a transient hypotension within 10 min, then their blood pressures recover to the initial level. Flavin adenine dinucleotide also prevents mitochondrial dysfunction induced by chlorpromazine. |
adenine-riboflavindinuceotide - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | AU7470000 |
| FLUKA BRAND F CODES | 8-10-21 |
| HS Code | 29349990 |
adenine-riboflavindinuceotide - Nature
| density | 2.08±0.1 g/cm3(Predicted) |
| storage conditions | −20°C |
| morphology | powder |
| acidity coefficient (pKa) | 1.13±0.50(Predicted) |
| color | orange |
| Merck | 4091 |
| stability | Stable. Incompatible with strong oxidizing agents. |
| EPA chemical information | Riboflavin 5'-(trihydrogen diphosphate), P'.fwdarw.5'-ester with adenosine (146-14-5) |
Last Update：2024-04-10 22:29:15
adenine-riboflavindinuceotide - Introduction
biological activity
Flavin adenine dinucleotide (FAD) is a redox cofactor, a proxil of protein, which participates in several important enzyme reactions during metabolism.
target
Human Endogenous Metabolite
in vitro study
Poly(Flavin adenine dinucleotide, FAD) characterized by an additional polymer-type redox reaction is a highly effective electrocatalyst for NADH oxidation: operating at the lowest potentials reported for NADH transducers (0.00 V, pH 7.4), poly(FAD) is characterized by the electrochemical rate constant of 1.8±0.6×10 -3 cm/s, which is at the level of the NADH mass-transfer constant. Poly(FAD)-modified electrodes are characterized by the dramatically improved stability and, is the most advantageous NADH transducers for analytical chemistry.
in vivo studies
Flavin adenine dinucleotide (2 mg/kg, I .v.) significantly cancels chlorpromazine (CPZ)-induced decrease in ventricular fibrillation threshold (VFT). Flavin adenine dinucleotide cancels the effect of CPZ on canine heart mitochondria. After injection of Flavin adenine dinucleotide, the dogs show a transient hypotension within 10 min, then their blood pressures recover to the initial level. Flavin adenine dinucleotide also prevents mitochondrial dysfunction induced by chlorpromazine.
Last Update：2024-04-10 22:29:15
adenine-riboflavindinuceotide - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Introduction | Flavin adenine dinucleotide (English: FAD), also known as active vitamin B2, riboflavin -5 '-adenosine diphosphate, is a redox coenzyme involved in important metabolic reactions. FAD is a stronger oxidant than NAD and NADP, which can be reduced by 1 electron or 2 electron pathways. It can be used for labeling xanthine adenine oxidase, riboflavin kinase tumor necrosis factor receptor 1 NADPH oxidase. |
| biological activity | Flavin adenine dinucleotide (FAD) is a redox cofactor, a proto of protein, which participates in several important enzyme reactions in the metabolic process. |
| use | suitable for skin and mucous membrane diseases, nervous tinnitus, cerebral arteriosclerosis, intractable headache, liver cirrhosis, jaundice and other liver diseases, eye diseases and retinal diseases. Transient chest discomfort was noted if the intravenous injection was too fast. |
Last Update：2024-04-10 22:29:15
adenine-riboflavindinuceotide - Security information
| safety instructions | 24/25 |
| WGK Germany | 3 |
| RTECS number | AU7470000 |
| F | 8-10-21 |
| customs code | 29349990 |
Last Update：2024-04-10 22:29:15
Supplier List
Featured Products
Product Name: FAD Request for quotationCAS: 146-14-5
Tel: 0755-27208059
Email: alex@hygieia.com.cn
Mobile: 13342904611
QQ: 3445655213
Featured Products
Product Name: FAD Request for quotationCAS: 146-14-5
Tel: 0755-27208059
Email: alex@hygieia.com.cn
Mobile: 13342904611
QQ: 3445655213
View History